Changes in Plasma Level of Heat Shock Protein 27 After Acute Coronary Syndrome

Abstract

We assessed the association between serum heat shock protein 27 (Hsp-27)concentrations in patients with acute coronary syndrome (ACS) and compared them with healthy participants. Patients with ACS (n = 75) were recruited and their biochemical parameters were compared with 75 healthy participants. Heat shock protein 27 concentrations were measured from blood samples taken on admission and 12 hours after the onset of chest pain. In the patient group, Hsp-27 concentrations (31.62 [20.12-38.51] ng/mL) in the first blood samples were significantly (P < .001) higher than in control samples (20.12 [16.67-28.17] ng/mL). In patients, serum Hsp-27 levels on admission were significantly (P < .001) higher than for the samples collected 12 hours after the onset of chest pain (25.87 [15.52-31.62]); the latter did not differ significantly from samples of healthy controls. In conclusion, serum Hsp-27 concentrations are elevated in the early hours following ACS, but fall to levels near to those in healthy individuals after about 12 hours from the onset of chest pain.

Heat shock protein 27 as a predictor of prognosis in patients admitted to hospital with acute COPD exacerbation

“…Increased concentrations of circulating HSP27 are reported in different cancers, including lung cancer (Zimmermann et al 2012), breast cancer (Fanelli et al 1998;Banerjee et al 2011), hepatocellular carcinoma (Gruden et al 2013), pancreatic carcinoma (Liao et al 2009;Melle et al 2007), gastric adenocarcinoma (Huang et al 2010), endometrial cancer and leukaemia. Lastly, elevated concentrations of circulating HSP27 have been observed in patients with cardiovascular disease (Jozefowicz-Okonkwo et al 2009;Park et al 2006;Zhang et al 2017;Jin et al 2014;Heidari-Bakavoli et al 2012), multiple sclerosis (Ce et al 2011), diabetes (Gruden et al 2008;Jakhotia et al 2018) or renal injury (Jakhotia et al 2018;Musial and Zwolinska 2012;Lebherz-Eichinger et al 2012). All these observations culminate to suggest that HSP27, when found its way to the extracellular milieu, seems to have manifold functions, similar as reported from its intracellular presence.…”

Changes in anti-heat shock protein 27 antibody and C-reactive protein levels following cardiac surgery and their association with cardiac function in patients with cardiovascular disease

“…We have previously found that anti-Hsp27 antibody titers rise and fall rapidly after the onset of ACS, suggesting that anti-Hsp27 antibody may be an early marker of myocardial ischemia (Ghayour-Mobarhan et al 2008). Moreover, in ACS patients, elevated serum Hsp27 antigen concentrations in the early hours following ACS has been found, but its concentrations fell to levels near to those in healthy individuals after about 12 h from the onset of chest pain (Heidari-Bakavoli et al 2012).…”

Increased Serum Heat Shock Protein 27 Antibody Titers and Prooxidant-Antioxidant Balance in Patients with Beta-Thalassemia Major

“…We have previously demonstrated that anti-Hsp27 may be a predictor of risk for atherosclerosis [61,62,63,64] and that Hsp27 and its antibody concentrations are related to the presence of cardiovascular complications in patients with glucose intolerance [65]. Azarpazhooh et al [61] reported that serum anti-Hsp27 titers are elevated in patients with stroke, and Wick et al [66] have hypothesized that an immune response to Hsp27, either endogenously derived from cells involved in atherogenesis or exogenously, from microorganisms, may lead to endothelial injury and subsequent atherosclerosis.…”