CHANGES IN PLASMA IL-1β, TNF-α AND IL-6 AFTER TOTAL HIP REPLACEMENT SURGERY IN GENERAL OR REGIONAL ANAESTHESIA

Høgevold, Hans Erik; Lyberg, Torstein; Kähler, Hanne; Haug, Egil; Reikerås, Olav

doi:10.1006/cyto.2000.0675

Cited by 77 publications

(67 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The combination spinal/epidural anesthesia has been shown a significant reduction of postoperative cortisol peak with respect to general anesthesia [143]. This effect has been confirmed after several major surgeries [144].…”

Section: Local Anestheticsmentioning

confidence: 75%

“…Local anesthetics are used to perform peripheral and central blocks, which can be an adjuvant of general anesthesia or used as sole type of anesthesia. Therefore, beside the direct effect on the immune system, local anesthetics affect the immunity by blocking the sympathetic nervous system and by attenuating the surgical stress [32,36].The combination spinal/epidural anesthesia has been shown a significant reduction of postoperative cortisol peak with respect to general anesthesia [143]. This effect has been confirmed after several major surgeries [144].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Anesthesia, cytokines and cancer recurrence

Kitamura¹,

Biaso²,

Ingelmo

et al. 2015

Glob Anesth Perioper Med

View full text Add to dashboard Cite

Cytokines are essential mediators for the regulation of both innate and acquired immunity and hematopoiesis. They modulate immune cell signaling, activation, adhesion and functioning. They regulate the individual response to several insults such as infection, inflammation, trauma, and pain. Moreover, the balance between pro-inflammatory and anti-inflammatory cytokines is critical for the evolution of surgical complications and tumor progression.Several drugs, including anesthetic agents, influence cytokines secretion. Opioids, inhalational agents, intravenous and local anesthetics have shown different effects on immune system and cytokine expression. Therefore, anesthesia may play an important role in postoperative recovery and outcome of cancer patients.The aim of the present article is to review the main role of some important cytokines and the effect of anesthesia techniques and drugs on their secretion. Furthermore, current clinical evidence regarding the effects of anesthesia on cancer recurrence will be discussed. Cytokines and immune systemCytokines are proteins expressed in both innate and acquired immune system and are often named according to the secreting cells (i.e., lymphocytes, interleukins, etc.). They are essential mediators of the natural (non-specific, innate) immunity, which is the initial step of the inflammatory response. They also play a pivotal role during the specific immunity, which occurs after exposure to antigens, as they regulate lymphocyte and leukocyte activation, growth and differentiation, and the immune-mediated inflammation [1].The cytokines have different structures, but also common aspects, which are summarized in Table 1.The aim of the present article is to review the main role of some important cytokines and the effect of anesthesia techniques and drugs on their secretion. Cytokines receptorsThe cytokines receptors are formed by one or more transmembrane proteins: the extracellular portion binds the cytokine, whereas the cytoplasmic part starts the signal cascade. Based on the extracellular portion, they are divided in five categories. 1) Type I receptors, which have four α-helical stands and contain four cysteine residues and the amino acid motif tryptophanserine-X-tryptophan-serine (WSXWS).2) Type II receptors, structurally similar to Type I receptors, but without the sequence WSXWS. Cytokines functionProvided that the same cytokine may be produced during both innate and acquired immunity response, cytokines can be classified according to their functions: 1)Cytokines regulating the innate immunity and secreted by stimulated macrophages; 2)Cytokines regulating the acquired immunity and secreted by lymphocytes; 3)Cytokines stimulating the hematopoiesiss and secreted by bone marrow, leucocytes and other cells. Common aspects of CytokineTheir secretion is brief and limited in time Cytokine expressed during the innate immunity response Tumor necrosis factor (TNF-α, TNF-β)The TNF is responsible for the initial phase of acute inflammatory response, especially against ...

show abstract

Section: Local Anestheticsmentioning

confidence: 75%

mentioning

confidence: 99%

Anesthesia, cytokines and cancer recurrence

Kitamura¹,

Biaso²,

Ingelmo

et al. 2015

Glob Anesth Perioper Med

View full text Add to dashboard Cite

show abstract

“…However, although in different types of orthopaedic surgery CRP levels remained consistently elevated (10-20 mg/dl) between 48 and 72 postoperative hours [11,29,31], postoperative IL-6 time-courses were variable, even for a particular surgery, both in the concentrations attained and in the time to reach peak values (4-24 h) [11,13,33]. Hence, since IL-6 was not determined at 6-8 postoperative hours, a possible significant difference between groups in IL-6 levels at that time can not be excluded.…”

Section: Effect Of the Treatment On Inflammatory Mediatorsmentioning

confidence: 99%

Acute phase response in patients undergoing lumbar spinal surgery: modulation by perioperative treatment with naproxen and famotidine

et al. 2003

View full text Add to dashboard Cite

“…Tissue damage, surgical stress, and pain cause afferent neuronal stimulation and the activation of cellular and humoral immune pathways that are associated with local inflammatory reactions and the accompanying elevations in the biological mediators such as cytokines (1,2). Proinflammatory cytokines, especially IL-6 and TNF-α, play an important role in the development of hyperalgesia and mechanical allodynia (3). The management of analgesia may affect neuroendocrine responses and attenuate proinflammatory cytokine production.…”

Section: Introductionmentioning

confidence: 99%

Pediatrik Hastalarda Preemptif Epidural İnfüzyonun Postoperatif Ağrı ve Sitokin Cevaba Etkisi

Tütüncü¹,

Erbabacan²,

Korkmaz³

et al. 2013

haseki

View full text Add to dashboard Cite

ÖzetAmaç: Cerrahi travma ve ağrı nedeniyle metabolik, endokrin, immün sistemde oluşan değişiklikler sitokin gibi biyolojik mediatörlerin artışı ile beraberdir. Preemptif epidural analjezi, cerrahi travmanın neden olduğu ağrı ve nöromediatörlerin oluşturduğu nörohümoral cevabı etkileyebilir. Bu çalışmada preemptif epidural analjezinin postoperatif ağrı ve sitokin düzeyine etkisinin araştırılması amaçlandı. Yöntem: Ürolojik cerrahi planlanan 60 çocuk; preemptif epidural analjezi (Preempt EA, n=31) grup ve postoperatif epidural analjezi grubu olarak (Postop EA, n=29) randomize iki gruba ayrıldı. Epidural infüzyon; Preempt EA grubunda cerrahi insizyon öncesi, Postop EA grubunda periton kapanışından sonra başlandı. Kan örnekleri preoperatif dönem, cerrahiden 1 saat ve 24 saat sonrasında ELISA yöntemi ile plazma TNF-α ve IL-2 düzeylerini tespit için alındı. Postoperatif ağrı FACES ağrı skalası ile cerrahiden 1 ve 24 saat sonrasında değerlendirildi. Bulgular Abs tractAim: Changes in the metabolic, endocrine, and immune systems caused by surgical trauma and pain are associated with increased concentrations of the biological mediators such as cytokines. Preemptive epidural analgesia may affect pain caused by surgical trauma and the corresponding neurohumoral response induced by the neuromediators. This study investigated the effects of preemptive epidural analgesia on postoperative pain and cytokine levels. Methods:A total of 60 children undergoing urological surgery were randomly assigned to either the preemptive epidural analgesia (Preempt EA, n=31) group or the postoperative epidural analgesia (Postop EA, n=29) group. Epidural infusion was started before the surgical incision in Preempt EA group and after the peritoneal closure in the Postop EA group. Blood samples were collected preoperatively (before anesthesia induction), 1 h and 24 h after surgery. Plasma TNF-α and IL-2 levels were measured by ELISA. Postoperative pain was assessed using the FACES pain scale, and postoperative analgesia was evaluated 1 h and 24 h after surgery.Results: Although TNF-α levels were increased 1 h and 24 h after surgery compared to preoperative levels in both groups, the levels were significantly higher in the Postop EA group. IL-2 levels were significantly higher at both postoperative time points in the Preempt EA group than in the Postop EA group. There were no significant differences in pain scores between the groups. Conclusion:Our results suggest that preemptive epidural analgesia may attenuate the proinflammatory response but has no effect on pain intensity.

show abstract

CHANGES IN PLASMA IL-1β, TNF-α AND IL-6 AFTER TOTAL HIP REPLACEMENT SURGERY IN GENERAL OR REGIONAL ANAESTHESIA

Cited by 77 publications

References 11 publications

Anesthesia, cytokines and cancer recurrence

Anesthesia, cytokines and cancer recurrence

Acute phase response in patients undergoing lumbar spinal surgery: modulation by perioperative treatment with naproxen and famotidine

Pediatrik Hastalarda Preemptif Epidural İnfüzyonun Postoperatif Ağrı ve Sitokin Cevaba Etkisi

Contact Info

Product

Resources

About