Changes in Plasma Concentrations of Immunoreactive Inhibin, Estradiol and FSH Associated with Follicular Waves during the Estrous Cycle of the Cow

Kaneko, Hiroyuki; Kishi, Hisashi; Watanabe, Gen; Taya, Kazuyoshi; Sasamoto, Shigemi; Hasegawa, Yoshihisa

doi:10.1262/jrd.41.311

Cited by 68 publications

(60 citation statements)

References 39 publications

(59 reference statements)

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“…The inhibitory effects of exogenous progesterone on folliculogenesis are demonstrated in cyclic rats through the hypothalamic-pituitary axis, especially via lowering serum LH [34]. The present results concerning with FSH secretion compare favorably with the results of passive immunization against inhibin in other animals, such as rats [26], hamsters [16,17], cows [14], mares [24] and sheep [21,36], implying passive immunization against inhibin can induce superovulation in guinea pigs. Inhibin has the ability to suppress FSH secretion by directly inhibiting expression of the gene encoding the FSH β subunit in the pituitary gland [3,22].…”

Section: Discussionsupporting

confidence: 74%

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Regulatory Role of Inhibin in Follicle-Stimulating Hormone Secretion and Folliculogenesis in the Guinea Pig.

et al. 2001

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ABSTRACT. The effects of unilateral and bilateral ovariectomy and passive immunization against inhibin on follicle-stimulating hormone (FSH) secretions and follicular development in the guinea pig were investigated. Bilateral ovariectomy decreased plasma immunoreactive (ir-) inhibin rapidly and increased plasma FSH significantly. Unilateral ovariectomy decreased plasma ir-inhibin and increased plasma FSH temporarily, and doubled the number of ova released from the remaining ovary at the subsequent ovulation in guinea pigs. Injection of 1.0 ml inhibin antiserum significantly increased concentrations of plasma FSH at 6 hr onwards and the number of small follicles (100-200 µm in diameter) at 48 hr after the injection in guinea pigs bearing progesterone-containing implants. In vitro bioassay showed that inhibin antiserum could neutralize the suppression of ovarian homogenate on FSH secretion from cultured rat anterior pituitary cells. These results confirm the evidence that the ovary is the main source of inhibin secretion and both in vitro bioassay and passive immunization against inhibin show that the inhibin is a major regulator in the follicular development through FSH secretion in guinea pigs.

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Section: Discussionsupporting

confidence: 74%

“…Passive immunization against inhibin can increase the secretion of FSH in female guinea pigs [29] as well as in the other animals [14,16,17,21,26]. However, the mechanism that regulates the onset and completion of the compensatory response to hemiovariectomy remains obscure in guinea pigs.…”

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confidence: 99%

Regulatory Role of Inhibin in Follicle-Stimulating Hormone Secretion and Folliculogenesis in the Guinea Pig.

et al. 2001

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“…Receptors for E2 and P4 are highly expressed in the CL in the early luteal phase, which probably stimulates P4 secretion and prevents apoptosis [65]. Serum P4 concentration is near to zero around estrus and high during the luteal phase, with average peak levels ranging from 4.1-9.9 ng/ml [4,17,23,38,71]. A high correlation between CL diameter and P4 output was reported in [58,64,81].…”

Section: Progesteronementioning

confidence: 95%

“…P4 and E2 modulate FSH release via effects on the anterior pituitary and on the GnRH pulse generator in the hypothalamus. Some studies in cows show an FSH peak concurrently with the LH surge [38,40], while other studies fail to show a clear peak [4,10,24]. Basal FSH levels are about 5-10 ng/ml, and peak levels about 15 ng/ml [10,24].…”

Section: Follicle Stimulating Hormonementioning

confidence: 99%

A simple mathematical model of the bovine estrous cycle: Follicle development and endocrine interactions

Bôer

Stötzel

Röblitz

et al. 2011

Journal of Theoretical Biology

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Bovine fertility is the subject of extensive research in animal sciences, especially because fertility of dairy cows has declined during the last decades. The regulation of estrus is controlled by the complex interplay of various organs and hormones. Mathematical modeling of the bovine estrous cycle could help in understanding the dynamics of this complex biological system. In this paper we present a mechanistic mathematical model of the bovine estrous cycle that includes the processes of follicle and corpus luteum development and the key hormones that interact to control these processes. The model generates successive estrous cycles of 21 days, with three waves of follicle growth per cycle. The model contains 12 differential equations and 54 parameters. Focus in this paper is on development of the model, but also some simulation results are presented, showing that a set of equations and parameters is obtained that describes the system consistent with empirical knowledge. Even though the majority of the mechanisms that are included in the model are based on relations that in literature have only been described qualitatively (i.e. stimulation and inhibition), the output of the model is surprisingly well in line with empirical data. This model of the bovine estrous cycle could be used as a basis for more elaborate models with the ability to study effects of external manipulations and genetic differences. AMS MSC 2000: 92C42, 92C30, 90C31, 65L09

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“…The inhibin RIA showed no significant cross reaction with LH, FSH and prolactin of rats, cattle and sheep, and with GnRH, transforming growth factor, and activin, whereas the assay system cross-reacts with inhibin Pro-αC and free inhibin α-subunit (Kaneko et al, 1995). Results were expressed in terms of 32-kDa bovine inhibin.…”

Section: Rias For Iinhibin Fsh and Lhmentioning

confidence: 87%

Changes in Inhibin Secretion during Development of the Female Duck Embryo

Yang¹,

Arai²,

Wan³

et al. 2001

Zoological Science

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Changes in Plasma Concentrations of Immunoreactive Inhibin, Estradiol and FSH Associated with Follicular Waves during the Estrous Cycle of the Cow

Cited by 68 publications

References 39 publications

Regulatory Role of Inhibin in Follicle-Stimulating Hormone Secretion and Folliculogenesis in the Guinea Pig.

Regulatory Role of Inhibin in Follicle-Stimulating Hormone Secretion and Folliculogenesis in the Guinea Pig.

A simple mathematical model of the bovine estrous cycle: Follicle development and endocrine interactions

Changes in Inhibin Secretion during Development of the Female Duck Embryo

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