Changes in plasma alpha 1-acid glycoprotein concentration and selected immune response in broiler chickens injected with Escherichia coli lipopolysaccharide

Takahashi, Kyoko; Miyake, Noriko; Ohta, Takeshi; Akiba, Yukio; Tamura, Keiji

doi:10.1080/00071669889547

Cited by 41 publications

(25 citation statements)

References 12 publications

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“…The tendency of the simulated CV in the acute phase and antibody response across time initially to decrease with time after antigen exposure and subsequently (after the peak response) to increase again reflected the pattern of observed variability in the literature in some cases (Figure 9a, Trout et al, 1988;Kreukniet and van der Zijpp, 1990;Leitner et al, 1992;Takahashi et al, 1998;Jarosinski et al, 2002;Xie et al, 2002b;Bar-Shira and Friedman, 2006). Overall, the large variations in immunocompetence and immunoresponsiveness created by the stochastic simulation model are in agreement with the large ranges of CV observed in published studies.…”

Section: Observed Variation In Immunocompetencesupporting

confidence: 87%

Modeling Variability in Immunocompetence and Immunoresponsiveness

2008

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The purposes of this paper were to 1) develop a stochastic model that would reflect observed variation between animals and across ages in immunocompetence and responsiveness; and 2) illustrate consequences of this variability for the statistical power of genotype comparisons and selection. A stochastic model of immunocompetence development and responsiveness kinetics was developed. This model enabled variability in immunological variables to be taken into account in the evaluation of challenge and measurement strategies for selection. The characteristics of the variation in model output reflect those observed in the literature, to the extent that variation in the literature shows a consistent pattern; knowledge of true variation and patterns of variation in immunological variables is limited. The model created correlations between immunocompetence and immunoresponsiveness components, as well as correlations within each component across time. These correlations were generally in agreement with literature estimates, where available. The model enabled predictions of the effectiveness of selection for improved health through immunocompetence or immunoresponsiveness. It was predicted that effective selection for increased general immunocompetence to improve health should be done only when baseline immunity has matured. Further, the model implied that selection is unlikely to be successful if it is based only on a single measurement. Problems with low statistical power to detect differences between genotypes can be reduced by increasing challenge age in the experimental design, and one should ensure that the effects of maternal immunity are minimal when the challenge is done. The ability to detect differences between different groups of animals differs substantially with measurement timing because of low repeatabilities of immunocompetence and responsiveness across time. In general, the probability of detecting differences becomes higher when the challenge age is increased. Consequently, both the age at selection and the age at which information is gathered for selection must be considered carefully when designing genetic evaluations.

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Section: Observed Variation In Immunocompetencesupporting

confidence: 87%

Modeling Variability in Immunocompetence and Immunoresponsiveness

2008

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“…It is known that measurement of plasma AGP and zinc concentration and IL-1 like activity are useful for the evaluation of certain conditions of disease and stress (Fleck, 1989;Takahashi, et al, 1994Takahashi, et al, , 1998. The measurement procedure for IL-1 like activity used in this experiment is not specific to determine IL-1 production or release.…”

Section: Resultsmentioning

confidence: 97%

Effect of dietary xylitol on growth and inflammatory responses in immune stimulated chickens

Takahashi¹,

Onodera²,

Akiba³

1999

British Poultry Science

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It has been argued that stimulation of the immune system depresses performance. Accordingly, an experiment was conducted to determine the effect of dietary xylitol (150 g/kg diet) on growth and selected inflammatory responses in male broiler chickens. During the final 6 d of the experimental periods, chicks were injected with antigens: Escherichia coli lipopolysaccharide (LPS) on days 1, 3 and 5 and with Sephadex-G50 superfine on days 2 and 4 to stimulate macrophage functions. The immune stimulation reduced body weight gain and food intake, but enhanced alpha 1 acid glycoprotein (AGP) concentration and interleukin (IL-1) like activity in plasma. Feeding the xylitol diet partially, but significantly, prevented the reductions in body weight gain and food intake, without affecting the early stage of inflammatory responses triggered by LPS and Sephadex injections.

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“…a 1 -Acid glycoprotein, ceruloplasmin, transferrin, fibronectin and serum amyloid A are important acute phase proteins in serum that are known to increase in concentration in poultry during an inflammatory response (Curtis & Butler, 1980;Nakamura et al, 1998;Takahashi et al, 1998;Chamanza et al, 1999). Repeated administration of LPS reduces the response, but the mechanisms responsible for this phenomenon have not yet been elucidated.…”

Section: Introductionmentioning

confidence: 97%

The influence of age and repeated lipopolysaccharide administration on body temperature and the concentration of interleukin-6 and IgM antibodies against lipopolysaccharide in broiler chickens

et al. 2008

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Our objective was to create a standardized and reproducible inflammation model in chickens in order to study the pharmacodynamics of several anti-pyretic and anti-inflammatory drugs. We studied the influence of age and repeated lipopolysaccharide (LPS) administration on body temperature and the correlation of this with concentrations of interleukin-6 and IgM antibodies against LPS in plasma of chickens. Three-week-old and 5-week-old broilers were injected intravenously with LPS from Escherichia coli O127: B8 at a dose of 1 mg/kg. LPS administration was repeated after 2 or 7 days. After the first dose of LPS, the body temperature was initially decreased below normal and then later increased above normal. The second dose of LPS reduced the level of hypothermia and the duration of the febrile phase. Three-week-old birds responded to LPS with a higher maximum body temperature and a greater area under the body temperature versus time curve than 5-week-old chickens (P<0.05). Interleukin-6 reached its highest concentration 3 h after LPS administration and returned to baseline levels after 9 h. A second dose of LPS resulted in a significantly lower peak in interleukin-6. Significant higher levels of antibodies against LPS could be detected 7 days after LPS administration. However, there appeared to be no correlation between the reduced response to LPS and the presence of antibodies.

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Changes in plasma alpha 1-acid glycoprotein concentration and selected immune response in broiler chickens injected with Escherichia coli lipopolysaccharide

Cited by 41 publications

References 12 publications

Modeling Variability in Immunocompetence and Immunoresponsiveness

Modeling Variability in Immunocompetence and Immunoresponsiveness

Effect of dietary xylitol on growth and inflammatory responses in immune stimulated chickens

The influence of age and repeated lipopolysaccharide administration on body temperature and the concentration of interleukin-6 and IgM antibodies against lipopolysaccharide in broiler chickens

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