Changes in Peripheral Refraction, Higher-Order Aberrations, and Accommodative Lag With a Radial Refractive Gradient Contact Lens in Young Myopes

Pauné, Jaume; Thivent, Solène; Armengol, Jesús; Quevedo, Lluı̈sa; Faria‐Ribeiro, Miguel; González-Meijóme, José Manuel

doi:10.1097/icl.0000000000000222

Cited by 32 publications

(43 citation statements)

References 76 publications

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“…Because of the increasing public health risk associated with myopia, many clinical research studies are evaluating possible therapeutic devices for slowing the rate of myopia progression in children. 1, 3, 27 These studies require the longitudinal assessment of refractive error changes, which necessitates clear knowledge of instrument validity and repeatability in children. Additionally, aberrometry measurements are commonly made when there is an interest in image quality, such as in studies evaluating refractive error, contact lenses for myopia control, and corneal diseases such as keratoconus.…”

Section: Discussionmentioning

confidence: 99%

“…1–5 Grand Seiko autorefractors (Grand Seiko Co., Hiroshima, Japan), also manufactured under the name Shin-Nippon, are frequently used in clinical studies to objectively measure refractive error because of their well-documented repeatability; however, the Grand Seiko autorefractor does not measure higher-order aberrations. 6–12 Hartmann-Shack aberrometry has been widely used in clinical research over the last several decades.…”

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confidence: 99%

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Aberrometry Repeatability and Agreement with Autorefraction

Nguyen

Berntsen

2017

Optom Vis Sci

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Significance Commercially-available aberrometers are essential to clinical studies evaluating refractive error and image quality. The Discovery System is a promising clinical instrument that allows investigators to export aberration data for research and analysis purposes. An assessment of the Discovery System’s performance is essential to the interpretation of the data obtained. Purpose To determine the between-visit repeatability of refractive error and higher-order aberration measurements with the Discovery System, and to examine between-instrument agreement of refractive error measurements with the Discovery System and Grand Seiko WAM-5500 open-field autorefractor. Methods Cycloplegic refractive error values from the Discovery System (over a 3-mm pupil) and the Grand Seiko autorefractor were converted to power vectors (M, J0, and J45) and averaged. Zernike coefficients were also calculated by the Discovery System over a 6-mm pupil through the 6th radial order. Between-visit repeatability and agreement were evaluated using Bland-Altman difference versus mean plots. T-tests compared each mean difference (bias) to zero and the 95% limits of agreement (LoA) were calculated. Results Twenty-five young adults with a mean (±SD) cycloplegic spherical-equivalent refractive error of −2.91 ± 1.85 D (range: −6.96 to +0.74) were enrolled. There were no significant between-visit differences with the Discovery System for M, J0, J45, 3rd through 6th order RMS, HORMS, or spherical aberration (all p > 0.30), and repeatability for defocus and HORMS were ±0.31 D and ±0.095 μm, respectively, for a 6-mm pupil. At a 3-mm pupil, the Discovery System on average measured slightly more positive values than the Grand Seiko for M (0.28 D), J0 (0.11 D), and J45 (0.12 D; all p <0.005). Conclusions The Discovery System was very repeatable and would be an appropriate instrument to measure cycloplegic refractive error and higher-order aberration changes in adults. Small differences in refractive error were found between the Discovery System and Grand Seiko.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Aberrometry Repeatability and Agreement with Autorefraction

Nguyen

Berntsen

2017

Optom Vis Sci

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“…Other studies previously have evaluated the aberrations and the light disturbance induced by wearing CL designed for myopia control. 22,32 Center-distance design MFCL, which were previously considered favorable to myopia control by producing peripheral relative myopia, were evaluated by several authors such as Fedtke et al 33 MFCL were shown to signi cantly induce positive shifts in primary SA (4th order SA), whose absolute value increased according to the increase of pupil size and add power. Dual-focus designed lenses also produced positive SA in 3 mm pupil size, but conversely, in greater pupil sizes of 4 mm, a higher negative value of 4th order SA was found, and even more so in the 5 mm pupil size.…”

Section: Discussionmentioning

confidence: 99%

Ocular and Corneal Aberrations changes in controlled randomized clinical trial MiSight® Assessment Study Spain (MASS)

Lopes-Ferreira

Ruiz-Pomeda

Pérez-Sánchez

et al. 2020

Preprint

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BackgroundTo compare ocular and corneal inherent aberrations in the naked eyes of randomly selected children fitted with MiSight contact lenses (CL) for myopia control, versus children corrected with single-vision spectacles (control), over a 24-months period.MethodsChildren aged 8 to 12 years, with myopia (-0.75 to -4.00 D sphere) and astigmatism (< -1.00 D cylinder), were assigned to the lens study group (MiSight) or the control group (single-vision spectacles). Axial length (AL) was measured by biometry, corneal RMS (RMS_C), corneal high order RMS (HO_RMS_C), corneal low order RMS (LO_RMS_C), ocular total RMS (RMS_T), ocular total high order RMS (HO_RMS_T), ocular total low order RMS (LO_RMS_T), corneal spherical aberration (SA_C) and ocular total SA (SA_T) were calculated by aberrometric measures at the baseline, and on 12- and 24-months visits. A 5 mm diameter was defined for the analysis in all visits for all subjects. Only the dominant eye was analyzed.ResultsSeventy-four subjects completed the clinical trial: 41 subjects from the MiSight group (age: 11.01 ± 1.23 years) and 33 from the single-vision group (age: 10.12 ± 1.38 years). In the control group, axial length changed significantly (0.444 ± 0.049 mm, p < 0.001) after 2 years. Also RMS_T (0.565 ± 0.199 µm, p = 0.029) and LO_RMS_T (0.461 ± 0.175 µm, p = 0.047) registered significant changes after 24-months in the control group. In the MiSight group, only axial length changed significantly (0.284 ± 0.025 mm, p < 0.001) after 2 years. The SA_C and SA_T did not reveal significant changes between visits or between groups.ConclusionsThe wear of MiSight CL did not induce significant changes in aberrations in anterior cornea and contrary of control group the total ocular RMS and low order RMS did not significantly caused by significantly lower eye growth and myopia progression,Trial registration: ClinicalTrials.gov Identifier: NCT01917110.

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“…In the context of the Cambridge Antimyopia Study, though improvements in accommodative efficiency were observed with soft contact lenses inducing negative spherical aberration, these devices were not successful in retarding axial elongation in teenagers [120]. Other studies reporting such results generally agreed that no significant changes are observed with peripheral gradient contact lenses [11], concentric dual-focus [42,122], and defocus incorporated soft contact lens [125].…”

Section: Accommodation Functionmentioning

confidence: 99%

“…In this review article, we present an overview of the recent developments of bifocal and multifocal contact lens designs for the correction of presbyopia and myopia control, including the optical design of different platforms for bifocality and multifocality, computational simulations and performance assessment, and their connection with the visual performance, patient acceptance, and efficacy. For further information on the performance of earlier designs for presbyopia correction [1,9] and myopia control, including orthokeratology [10,11], the reader must consult the abundant existing literature including several systematic reviews and meta-analyses on the former topic [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Bifocal and Multifocal Contact Lenses for Presbyopia and Myopia Control

Remón

Pérez-Merino

Macedo-de-Araújo

et al. 2020

Journal of Ophthalmology

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Bifocal and multifocal optical devices are intended to get images into focus from objects placed at different distances from the observer. Spectacles, contact lenses, and intraocular lenses can meet the requirements to provide such a solution. Contact lenses provide unique characteristics as a platform for implementing bifocality and multifocality. Compared to spectacles, they are closer to the eye, providing a wider field of view, less distortion, and their use is more consistent as they are not so easily removed along the day. In addition, contact lenses are also minimally invasive, can be easily exchangeable, and, therefore, suitable for conditions in which surgical procedures are not indicated. Contact lenses can remain centered with the eye despite eye movements, providing the possibility for simultaneous imaging from different object distances. The main current indications for bifocal and multifocal contact lenses include presbyopia correction in adult population and myopia control in children. Considering the large numbers of potential candidates for optical correction of presbyopia and the demographic trends in myopia, the potential impact of contact lenses for presbyopia and myopia applications is undoubtedly tremendous. However, the ocular characteristics and expectations vary significantly between young and older candidates and impose different challenges in fitting bifocal and multifocal contact lenses for the correction of presbyopia and myopia control. This review presents the recent developments in material platforms, optical designs, simulated visual performance, and the clinical performance assessment of bifocal and multifocal contact lenses for presbyopia correction and/or myopia progression control.

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Changes in Peripheral Refraction, Higher-Order Aberrations, and Accommodative Lag With a Radial Refractive Gradient Contact Lens in Young Myopes

Abstract: Myopia should be viewed as a progressive condition associated with the potential risk of 54 visual loss. Moreover, the prevalence of myopia is increasing in Asian urban regions 55

Cited by 32 publications

References 76 publications

Aberrometry Repeatability and Agreement with Autorefraction

Aberrometry Repeatability and Agreement with Autorefraction

Ocular and Corneal Aberrations changes in controlled randomized clinical trial MiSight® Assessment Study Spain (MASS)

Bifocal and Multifocal Contact Lenses for Presbyopia and Myopia Control

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