Changes in peptidergic neurotransmission during postoperative ileus in rat circular jejunal muscle

Goetz, B; Benhaqi, Petra; Glatzle, Joerg; Müller, Mitho; Schmitt, Stephanie; Brändli, André W.; Kreis, Martin E.; Kasparek, Michael S.

doi:10.1111/nmo.12275

Cited by 7 publications

(2 citation statements)

References 53 publications

(114 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, inflammation is considered as the main mechanism leading to dysmotility in POI mainly by direct inhibition of smooth muscle function . However, the impact of the surgical trauma and related inflammation on neural function has been poorly investigated . As intestinal inflammation induces structural changes of the enteric nervous system (ENS) and alters neurotransmission in many inflammatory conditions, we hypothesized that similar mechanisms could contribute to POI.…”

Section: Introductionmentioning

confidence: 99%

“…4 However, the impact of the surgical trauma and related inflammation on neural function has been poorly investigated. 8,9 As intestinal inflammation induces structural changes of the enteric nervous system (ENS) and alters neurotransmission in many inflammatory conditions, [10][11][12] we hypothesized that similar mechanisms could contribute to POI. Therefore, we designed our study focusing on alterations of the enteric neurons at functional and morphological level after manipulation of the small bowel in a murine model of POI.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Smooth muscle and neural dysfunction contribute to different phases of murine postoperative ileus

Farro

Gomez‐Pinilla

Giovangiulio

et al. 2016

Neurogastroenterology Motil

View full text Add to dashboard Cite

Intestinal manipulation induces two waves of smooth muscle inhibition, most likely mediated by inflammatory cytokines, lasting up to 3 days after IM. Further, we here identify a late third phase (>24 h) characterized by impaired cholinergic and nitrergic neurotransmission persisting after recovery of muscle contractility. These findings illustrate that POI results from inflammation-mediated impaired smooth muscle contraction, but also involves a long-lasting impact of IM on the enteric nervous system.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Smooth muscle and neural dysfunction contribute to different phases of murine postoperative ileus

Farro

Gomez‐Pinilla

Giovangiulio

et al. 2016

Neurogastroenterology Motil

View full text Add to dashboard Cite

show abstract

Critical Evaluation of Animal Models of Gastrointestinal Disorders

Johnson

Meerveld

2017

Handbook of Experimental Pharmacology

View full text Add to dashboard Cite

Preclinical research remains an important tool for discovery and validation of novel therapeutics for gastrointestinal disorders. While in vitro assays can be used to verify receptor-ligand interactions and test for structural activity of new compounds, only whole-animal studies can demonstrate drug efficacy within the gastrointestinal system. Most major gastrointestinal disorders have been modeled in animals; however the translational relevance of each model is not equal. The purpose of this chapter is to provide a critical evaluation of common animal models that are being used to develop pharmaceuticals for gastrointestinal disorders. For brevity, the models are presented for upper gastrointestinal disorders involving the esophagus, stomach, and small intestine and lower gastrointestinal disorders that focus on the colon. Particular emphasis is used to explain the face and construct validity of each model, and the limitations of each model, including data interpretation, are highlighted. This chapter does not evaluate models that rely on surgical or other non-pharmacological interventions for treatment.

show abstract

Posttraumatischer Briden-Ileus nach Beckenringfrakturen

et al. 2014

View full text Add to dashboard Cite

We report on two cases of posttraumatic ileus after pelvic ring fracture in two patients aged 73 and 74 years, respectively. Although all conservative measures were exhausted, in both cases the ileus resulted in additional operative procedures and a significant extension of the hospital stay. Intraoperatively both patients presented with a mechanical ileus caused by adhesions which were unapparent for decades. Only the trauma-related motility disorder led to a clinical manifestation. Pathophysiological mechanisms and their implications on prophylaxis and therapy are discussed.

show abstract

Changes in peptidergic neurotransmission during postoperative ileus in rat circular jejunal muscle

Abstract: Specific, time-dependent changes in peptidergic neurotransmission with VIP and Sub P occur during POI that are associated with vagal afferent activation, but are independent of the activation of efferent vagal pathways.

Cited by 7 publications

References 53 publications

Smooth muscle and neural dysfunction contribute to different phases of murine postoperative ileus

Smooth muscle and neural dysfunction contribute to different phases of murine postoperative ileus

Critical Evaluation of Animal Models of Gastrointestinal Disorders

Posttraumatischer Briden-Ileus nach Beckenringfrakturen

Contact Info

Product

Resources

About