Changes in patterns of uveitis at a tertiary referral center in Northern Italy: analysis of 990 consecutive cases

Cimino, Luca; Aldigeri, Raffaella; Sylvia, Marchi; Mastrofilippo, Valentina; Viscogliosi, Fabiana; Coassin, Marco; Soldani, Annamaria; Luisa, Savoldi; Alessandro, De Fanti; Belloni, Lucia; Zerbini, Alessandro; Parmeggiani, Maria; Chersich, Matthew; Soriano, Alessandra; Salvarani, Carlo; Fontana, Luigi

doi:10.1007/s10792-016-0434-x

Cited by 48 publications

(40 citation statements)

References 56 publications

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“…Using the Medline database, a review of the literature was performed from 1976–2017 that reported observational data from patients with uveitis in Europe, using the following terms for the literature search: ‘uveitis,’ ‘pattern of uveitis,’ ‘uveitis in Europe,’ and ‘epidemiology of uveitis.’ Twenty-four articles published in the years 1976–2017, reporting uveitis in 24,126 patients in Europe were identified [19–43]. The records of patients referred to the Department of Ophthalmology and the literature data were analyzed in terms of gender, age, and major causes of uveitis, to identify similarities and differences.…”

Section: Methodsmentioning

confidence: 99%

A Retrospective Observational Study of Uveitis in a Single Center in Poland with a Review of Findings in Europe

et al. 2018

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BackgroundThis study aimed to review the causes, presentation, and clinicopathological associations of uveitis in a single department of ophthalmology in Poland, and to compare the findings with previously published studies from other European countries.Material/MethodsReview of local patient records between 2005–2015 identified patients diagnosed with uveitis. Data obtained included age, gender, imaging findings, and laboratory diagnostic findings. A literature review identified 24 publications from 1976–2017 that reported observational data from patients with uveitis in Europe. Statistical analysis compared the findings.ResultsBetween 2005–2015, 279 patients were diagnosed with uveitis (mean age, 38.3±15.3 years) (61.6% women) including unilateral uveitis (60.5%), with posterior uveitis (48.4%), anterior uveitis (26.5%), and intermediate uveitis (12.9%). A general etiology was established in 76.3% and included ocular-specific syndromes (31.8%), infection (27.9%), and an association with systemic disease (16.8%), but 23.6% were unclassifiable. Specific causes of uveitis included toxoplasmosis (17.9%), Fuchs uveitis (12.2%), white dot syndromes (WDS) (10.4%), sarcoidosis (6.1%), toxocariasis (6.1%), HLA-B27-associated acute anterior uveitis (AAU) (5.7%), multiple sclerosis (4.7%), ankylosing spondylitis (3.6%) and herpesvirus infection (2.5%). Data from 26 published studies (24,126 patients with uveitis) from 12 European countries showed that idiopathic uveitis was most common (36.6%); the identified causes included toxoplasmosis (9.4%), WDS (7.2%), and Fuchs uveitis (6.1%).ConclusionsIn a single ophthalmic center in Poland, and throughout Europe, the causes of uveitis are varied. Genetic, geographic, social and environmental factors are likely to affect the cause of uveitis in different populations.

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Section: Methodsmentioning

confidence: 99%

A Retrospective Observational Study of Uveitis in a Single Center in Poland with a Review of Findings in Europe

et al. 2018

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“…1 Tuberculosis (TB) has historically been considered a major cause of uveitis, but the importance of TB as a primary cause of uveitis has gradually decreased in the last decades, although it has recently re-emerged. [2][3][4] TB is an infectious disease caused by Mycobacterium tuberculosis. One-third of the world's population is thought to be infected with M. tuberculosis and in 2015, 10.4 million new infections occured.…”

Section: Introductionmentioning

confidence: 99%

Tuberculosis and other causes of uveitis in Indonesia

Nora

Sitompul

Bakker

et al. 2017

Eye

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PurposeThe purpose of this study is to assess the causes of uveitis in Indonesia and determine the importance of tuberculosis (TB) as a cause of uveitis.Patients and methodsProspective cohort study examining 146 consecutive new human immunodeficiency virus-negative patients with active uveitis between June 2014 and May 2015. We assessed the anatomic locations and specific causes of uveitis, as well as associations with infectious and non-infectious systemic diseases. We determined the prevalence of positive QuantiFERON Tb Gold test (QFT) results in Indonesian patients with uveitis and calculated the number of patients with active systemic TB.ResultsPosterior and panuveitis were the most common anatomic entities (38% each). Infections represented the most frequent cause of uveitis (33%); the most prevalent were toxoplasmosis (19%) and active systemic TB (8%). The majority of patients were QFT positive (61%). A specific diagnosis could not be established in 45% of the patients. At first presentation to the ophthalmologist, the majority of patients (66%) had a visual acuity of less than finger counting at 3 m and already exhibited various complications of uveitis. When classifying the QFT-positive patients with unexplained uveitis into a TB-related group, the percentage of 'TB-associated' uveitis cases increased from 8-48%. Highly elevated QFT levels were observed in patients with uveitis of unknown cause and no signs of active systemic TB.ConclusionsIn Indonesia, infectious uveitis was the most common type of uveitis and the leading causes consisted of toxoplasmosis and TB. The association observed between highly elevated QFT results and uveitis of otherwise unexplained origins indicates that a link exists between the latent TB infection and the development of uveitis.

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“…Of 980 consecutive patients at the All India Institute of Medical Sciences from 2011 to 2013, 131 (13.36%) had intermediate uveitis [16]. In contrast, prevalence of intermediate uveitis was 5.5% of 990 patients in Northern Italy from 2013 to 2015 [17]. Miserocchi et al reviewed 24 uveitis surveys reporting over 26,000 patients that were published before 2012; the average reported prevalence of intermediate uveitis was 9.5 +/À 5.6% [18].…”

Section: Epidemiology Prevalencementioning

confidence: 99%

Intermediate Uveitis

Davis

2020

Albert and Jakobiec's Principles and Practice of Ophthalmology

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Changes in patterns of uveitis at a tertiary referral center in Northern Italy: analysis of 990 consecutive cases

Cited by 48 publications

References 56 publications

A Retrospective Observational Study of Uveitis in a Single Center in Poland with a Review of Findings in Europe

A Retrospective Observational Study of Uveitis in a Single Center in Poland with a Review of Findings in Europe

Tuberculosis and other causes of uveitis in Indonesia

Intermediate Uveitis

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