Changes in pattern of use, clinical characteristics and persistence rate of hormone replacement therapy among postmenopausal women after the WHI publication

Abstract

One year after publication, significant changes had already occurred in the trends of use, women's characteristics and estrogen dosage. No change in the proportion of new users with CVD risk factors or at very high risk of CAD was seen.

Trends in the pharmacological treatment of osteoporosis in Spain from 2000 to 2008

“…The reduction in menopausal hormone therapy use may reflect the awareness of the potential harms of these prescription drugs [7][8][9]. Similar trends in the consumption of menopausal hormone therapy have been observed in other countries [17][18][19]. It is likely that a part of the patients undergoing menopausal hormone therapy in the past were switched to other medications.…”

Why do stress and urge incontinence co-occur much more often than expected?

“…The evidence is less certain for urge UI. Note that estimates of UI prevalence are based on data primarily collected before publication of the WHI where 6-13% of women used HRTs, compared to 3-9% after the WHI trial [17][18][19][20].…”

“…In order, 1 to 4 up arrows indicate relative risks of 1.0-1.49, 1.5-1.99, 2.00-2.99, 3.0+. The complement is true for down arrows b Prevalence of HRT use is based on [17][18][19][20] c Prevalence of parity is based on [33,32] d Prevalence of prolapse is based on reference [47] e Prevalence of surgeries is based on [62] and is further adjusted for age and surgical success rate of 85% (see text) f Prevalence is obesity is based on [71] g Prevalence of diabetes is based on [81] stress UI developed before urge UI (22/28 versus 4/18, RR=3.54, CI=1.46-8.57, P<0.001) [87]. Eight years after tension-free vaginal tape surgery for stress and/or mixed UI, 85% of women with stress UI were in remission.…”

Effect of counseling on adherence to perimenopausal hormone therapy in Slovenia

“…The adherence rate to HT for a cohort studied before the publication of the WHI findings was 59%, compared with 45% for a cohort studied after the findings' publication [8]. The present study is the first from the eastern part of the European Union to analyze the effects of an educational intervention on HT adherence since the findings' publication.…”