Changes in ovine cervical mucus in response to oestrogen treatment

Adams, N. R.; Tang, Bing

doi:10.1530/jrf.0.0570261

Cited by 11 publications

(7 citation statements)

References 12 publications

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“…In the control ewes, increasing doses of oestradiol benzoate increased the weight of mucus and affected the Spinnbarkeit in the manner described previously (Adams & Tang, 1979) but no such changes were seen in affected ewes. A previous attempt to detect such a difference in response to oestrogen between control and affected ewes was unsuccessful (Smith, 1971) but, in that study the group size was smaller, and the ewes were pretreated with progesterone which can directly affect the nature of the secretion (Adams, 1981b).…”

Section: Discussionsupporting

confidence: 55%

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Changed control of cervical secretion from infertile ewes previously exposed to oestrogenic clover pasture

Adams¹,

Tang²

1986

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The amount of cervical mucus recovered from control ovariectomized ewes increased with increasing doses of oestradiol benzoate (OB), while the maximum Spinnbarkeit of mucus occurred at an intermediate dose of OB. Neither the amount nor the Spinnbarkeit of mucus varied with the dose of OB in ewes with permanent infertility caused by grazing oestrogenic pasture (clover-affected ewes). Furthermore, the increase in Spinnbarkeit of cervical mucus seen in normal ewes treated over a 3-day period with OB or with implants containing oestradiol did not occur in affected ewes. In control ewes treated repeatedly with OB, production of mucus declined within 5 days, but no change in secretion was detectable in clover-affected ewes. Therefore, neither the amount nor the duration of oestrogenic stimulation affected the cervical mucus in ewes with clover disease. Affected ewes produced more mucus than did controls in the absence of oestrogenic stimulation. It is concluded that the relatively normal volume of mucus in affected ewes treated with OB results largely from autonomous production. The Spinnbarkeit does not increase in these ewes because the ability of the cervix to respond to oestrogen is impaired.

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Section: Discussionsupporting

confidence: 55%

“…Cervical mucus was collected and examined as described previously (Adams & Tang, 1979). Briefly, all the available mucus from around the cervical os was aspirated into a 1 ml pipette.…”

Section: Methodsmentioning

confidence: 99%

Changed control of cervical secretion from infertile ewes previously exposed to oestrogenic clover pasture

Adams¹,

Tang²

1986

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“…In ovariectomized ewes, the production of mucus is limited and consists primarily of sulfomucins. The production of mucins is under endocrine control as supplementation with oestradiol benzoate increases the production of mucus, increases the water content and restores the production of sialomucins (Adams and Tang 1979, 1986). The secretions of the cervix are subject to morphological and biochemical changes during the oestrous cycle, as the amount of mucus and its degree of hydration increase considerably during oestrus (Katz et al.…”

Section: Secretions Of the Cervixmentioning

confidence: 99%

Sperm Interaction with the Female Reproductive Tract

Druart¹

2012

Reprod Domestic Animals

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Contents Sperm transit in the female tract is a critical event for the success of fertilization. From their deposition in the vagina to final migration in the oviduct, sperm pass through the different compartments of the genital tract in which they encounter different environments. The cervix and the uterotubal junction (UTJ) are two barriers with different relative importance according to the species. The protein composition, the degree of glycosylation and the hydration of the cervical mucus change during the oestrous cycle. Several sperm surface proteins are associated with their migration through the cervical mucus and the UTJ. Data regarding the interaction of sperm with secretions of the epithelial tissue lining the different compartments of the female genital tract during the sperm transit are reviewed, with a particular emphasis on the migration of sperm through the cervix.

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“…Thus the reduced degree of response may indicate either that the affected ewes showed a reduced response to oestrogen, or that the response seen at 24 h was a physiological maximum. The second alternative is unlikely, because cervical mucus production increases linearly at doses up to lOOpg oestradiol benzoate (Adams & Tang, 1979), and only 25 pg oestradiol were used in the present study. Furthermore, other studies have shown a depressed response in affected ewes in characteristics which are not raised initially, such as oestrous behaviour (Adams, 1978) and the spinnbarkeit of cervical mucus (Adams, 1979).…”

Section: Discussionmentioning

confidence: 99%

Apparently normal oestrogen receptor system in ovariectomized ewes with impaired response to oestrogen after prolonged grazing on oestrogenic pasture

Tang¹,

Adams²

1986

Journal of Endocrinology

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Functional abnormalities have been observed previously in the oestrogen-responsive tissues of ovariectomized ewes with permanent infertility resulting from prolonged exposure to oestrogenic pastures. In the present study, such ewes had higher rates of protein and glycoprotein synthesis in the cervix and uterus than control ewes, but the number of oestradiol-17 beta receptors in the nucleus was similar in each group. After treatment with oestradiol-17 beta, the increase in synthesis of protein and glycoprotein in the uterus and cervix was less in clover-affected ewes, but the amount of oestradiol-17 beta-receptor complex in the nucleus of uterine cells 6 h after ewes were injected with oestradiol-17 beta was similar in clover-affected and control ewes. The rate of replenishment of oestradiol-17 beta receptors in the cytoplasm at 24 and 48 h after oestradiol-17 beta injection was also similar in both groups. The abnormal function seen in the genital tract of clover-affected ewes could not, therefore, be shown to depend on changes in oestradiol-17 beta receptors.

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Changes in ovine cervical mucus in response to oestrogen treatment

Cited by 11 publications

References 12 publications

Changed control of cervical secretion from infertile ewes previously exposed to oestrogenic clover pasture

Changed control of cervical secretion from infertile ewes previously exposed to oestrogenic clover pasture

Sperm Interaction with the Female Reproductive Tract

Apparently normal oestrogen receptor system in ovariectomized ewes with impaired response to oestrogen after prolonged grazing on oestrogenic pasture

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