Changes in older adults' life space during lung cancer treatment: A mixed methods cohort study

Wong, Melisa L.; Shi, Ying; Smith, Alexander K.; Miaskowski, Christine; Boscardin, W. John; Cohen, Harvey Jay; Lam, Vivian; Mazor, Melissa; Metzger, Lia; Presley, Carolyn J.; Williams, Grant R.; Loh, Kah Poh; Ursem, Carling; Friedlander, Terence W.; Blakely, Collin M.; Gubens, Matthew A.; Allen, Gregory; Shumay, Dianne M.; Walter, Louise C.

doi:10.1111/jgs.17474

Cited by 13 publications

(23 citation statements)

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“…Details of our "Lung cancer in older adults: Treatment toxicity through the patient's lens" study (Lens Study) have been previously published [11]. Briefly, this is an observational cohort study that recruited older adults with advanced NSCLC from three sites within one Comprehensive Cancer Center (academic, Veterans Affairs, and safetynet oncology clinics).…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…For the qualitative substudy, we conducted semi-structured interviews with 20 English-speaking patients to understand the patient experience of functional change during NSCLC treatment [11]. To represent a diverse range of pretreatment function, relatively fit and more frail patients were purposively sampled based on the treating oncologists' clinical impressions of their pretreatment function.…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…In a study of older adults, >70% of those with cancer reported that they would not select a treatment that caused severe functional impairment, even if it improved survival [10]. Despite the importance of function to older adults with cancer, data on functional outcomes during NSCLC treatment remain limited [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, life-space mobility [21,22] is a widely used measure in the general aging literature that has recently started gaining traction in oncology [23,24] and geriatric oncology [11,25]. Life-space mobility, which can be measured using the patient-reported Life-Space Assessment (LSA) [21], describes an individual's ability to move within their environment from within their home to outside of town.…”

Section: Introductionmentioning

confidence: 99%

“…Among older adults without cancer, LSA predicts quality of life [26], healthcare utilization [27], and mortality [28]. Because life-space mobility incorporates physical, social, and cognitive functioning, it represents a broader assessment of function than measures that evaluate performance of individual activities [11].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Change in four measures of physical function among older adults during lung cancer treatment: A mixed methods cohort study

Singhal¹,

Walter²,

Smith³

et al. 2023

Journal of Geriatric Oncology

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Section: Study Design and Participantsmentioning

confidence: 99%

Section: Study Design and Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Change in four measures of physical function among older adults during lung cancer treatment: A mixed methods cohort study

Singhal¹,

Walter²,

Smith³

et al. 2023

Journal of Geriatric Oncology

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Restricted life‐space mobility impacts physical but not mental quality of life in older cancer survivors

Taylor,

Bakitas,

Wells

et al. 2023

Cancer Medicine

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BackgroundOlder cancer survivors often value quality of life (QOL) over survival. Life‐space mobility (LSM), defined as the individual's spatial geographic mobility range, is an important QOL indicator in older adults with chronic illnesses; however, this relationship is unexplored in older cancer survivors.MethodsWe examined the longitudinal associations and causal relationships between LSM and QOL in 153 older cancer survivors (≥65 years) from the University of Alabama at Birmingham (UAB) Study of Aging. LSM was assessed using the UAB Life‐Space Assessment‐Composite score (LSA‐C), and QOL was assessed by the SF‐12 Mental Component Score (MCS12) and Physical Component Score (PCS12) at 0 (study entry), 6, 18, 36, 54, and 72 months. We examined the causal relationship between LSM and QOL using a cross‐lagged panel model (CLPM).ResultsThe cohort (n = 153) was 76 years old on average and predominantly White (58%), female (58%), and married (55%). Longitudinal analyses found LSM decreased over time (p < 0.0001), and this decrease was associated with decreased QOL (PCS12, p < 0.0001, MCS12, p < 0.0001). In the CLPM causal analysis, lower LSM resulted in worse PCS12 (p < 0.001), but not worse MSC12.ConclusionsRestricted LSM resulted in worse physical QOL over 72 months in a sample of 153 older cancer survivors. Developing and evaluating interventions to preserve greater LSM could be a promising approach to improving QOL.

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Survivorship outcomes in patients treated with immune checkpoint inhibitors: a scoping review

Güven,

Thong,

Arndt

2024

J Cancer Surviv

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Background Immune checkpoint inhibitors (ICIs) have become a central part of cancer care. However, the survivorship outcomes in patients treated with ICIs are understudied. Therefore, we conducted a scoping review to evaluate the current status of the field and to establish research gaps regarding survivorship outcomes with ICIs in real-life cohorts. Methods We used the Web of Science, PubMed, and Embase databases to systematically filter published studies with real-life cohorts from January 1, 2010, until October 19, 2022. Studies evaluating at least one survivorship outcome in ICI-treated patients were included. Results A total of 39 papers were included. Quality of life (QoL) (n = 23), toxicity burden (n = 16), and psychosocial issues (n = 9) were the most frequently evaluated survivorship outcomes. Anti-PD-1/PD-L1 monotherapy and a response to treatment were associated with better QoL. In addition, the ICIs were associated with grade 3 or higher immune-related adverse events (irAEs) in 10–15% and late/long-term irAEs in 20–30% of the survivors. Regarding psychosocial problems, over 30% of survivors showed evidence of anxiety and depression, and 30–40% of survivors reported neurocognitive impairments. Conclusion The survivors treated with ICIs have impairments in most survivorship domains. Further research is needed to gather data on the understudied survivorship outcomes like late and long-term effects, fertility, financial toxicity, and return to work in survivors treated with ICIs. Implications for Cancer Survivors Available evidence demonstrates that a significant portion of survivors treated with ICIs have a significant toxicity burden, lower QoL than the general population, and a high rate of psychosocial problems.

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Changes in older adults' life space during lung cancer treatment: A mixed methods cohort study

Cited by 13 publications

References 50 publications

Change in four measures of physical function among older adults during lung cancer treatment: A mixed methods cohort study

Change in four measures of physical function among older adults during lung cancer treatment: A mixed methods cohort study

Restricted life‐space mobility impacts physical but not mental quality of life in older cancer survivors

Survivorship outcomes in patients treated with immune checkpoint inhibitors: a scoping review

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