Changes in ocular higher-order aberrations following botulinum toxin treatment in patients with blepharospasm

Isshiki, Yoshihiko; Ishikawa, Hiroto; Mimura, Osamu

doi:10.1007/s10384-016-0469-6

Cited by 14 publications

(10 citation statements)

References 27 publications

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“…Isshiki et al [19] found that there is significant improvement in both the Schirmer test and TBUT test results with reduction in high-order ocular aberrations in patients of blepharospasm treated with botulinum toxin. In addition to the previously mentioned tests, Park et al [20] added lower lid tear meniscus height measured by optical coherence tomography and dacryoscintigraphy using 99 m technetium pertechnetate with similar results, confirming the improvement of dry eye manifestations after BTA injection in blepharospasm patients.…”

Section: Discussionmentioning

confidence: 99%

Comparison Between Botulinum Toxin A Injection and Lacrimal Punctal Plugs for the Control of Post-LASIK Dry Eye Manifestations: A Prospective Study

Fouda

Mattout

2017

Ophthalmol Ther

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IntroductionLaser in situ keratomelieusis (LASIK) is one of the commonest refractive procedures performed nowadays. The dry eye problem is nearly universal in all patients after LASIK and it can be so annoying that the post-operative patient satisfaction is sometimes precluded. Conventional treatment includes the use of artificial tears. Alternative methods such as punctal plugs and botulinum toxin injection can be used for the management of post-LASIK dry eye. The aim of this study is to compare botulinum toxin injection in the orbicularis muscle to lacrimal punctal plugs for the control of post-LASIK dry eye manifestations.MethodsThis is a prospective study that included 60 patients who had LASIK eye surgery for correction of refractive errors. Patients were randomly assigned to one of three methods of dry eye management; the first method was conventional medical treatment with preservative-free tear substitutes only (group A: 20 patients = 40 eyes); the second method was intraoperative injection of botulinum toxin A (BTA) in the orbicularis muscle below the lower punctum of both eyes (group B: 20 patients = 40 eyes) and the third method was intraoperative insertion of temporary extended duration silicone punctal plugs in the lower punctum of both eyes (group C: 20 patients = 40 eyes).ResultsIn the first follow-up visit after 2 weeks, the two test groups (B, C) showed a statistically significant increase in both tear film break up time (TBUT) and Schirmer test score with a decrease in the OSDI score and daily frequency of lubricants used in comparison to the control group A. These differences were maintained in the next follow-up visit but they became statistically insignificant at the 3rd and 6th post-operative months. Complications were encountered more in the punctal plug patients (60%) than in BTA patients (25%) and this difference was statistically significant.ConclusionThe use of BTA injection to control dry eye symptoms by inducing temporary punctal ectropion is an effective method to improve patient satisfaction after LASIK eye surgery. It has higher level of patient satisfaction and fewer complications in comparison to punctal plugs or topical standard dry eye treatment.

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Section: Discussionmentioning

confidence: 99%

Comparison Between Botulinum Toxin A Injection and Lacrimal Punctal Plugs for the Control of Post-LASIK Dry Eye Manifestations: A Prospective Study

Fouda

Mattout

2017

Ophthalmol Ther

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“…This hypothesis was supported by Ho et al [31] who injected BoNT in patients with lateral canthal rhytides and showed significantly decreased tear film stability as assessed by TBUT at 1- and 3-months post-BoNT injection. However, in several studies, TBUT significantly increased following BoNT injection in patients with facial movement disorders [54,62,63,64,65]. Moreover, our previous data have shown a significant increase in LLT from baseline at 1-month post-treatment (89.9 ± 16.7 [one month] vs. 75.1 ± 21.2 [baseline], P = 0.01) [39].…”

Section: Bont Effects On Tear Film Stability and Meibomian Gland Cmentioning

confidence: 95%

A Review of Periocular Botulinum Neurotoxin on the Tear Film Homeostasis and the Ocular Surface Change

Fang

Chang

et al. 2019

Toxins

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Clinical usage of botulinum neurotoxin (BoNT) in ophthalmology has dramatically increased since the 1980s and has become one of the most widely used agents for treating facial movement disorders, autonomic dysfunction and aesthetic wrinkles. Despite its high efficacy, there are some complications with periocular BoNT injections due to its chemodenervation effect. Among these, there is still controversy over the BoNT effect on tear film homeostasis and the ocular surface. A periocular BoNT injection could dry the eye by reducing tear production of the lacrimal gland and increase tear evaporation due to potential eyelid malposition and abnormal blinks. On the contrary, the injection of BoNT in the medial eyelids could treat dry eye disease by impairing lacrimal drainage. Regarding the ocular surface change, corneal astigmatism and high-order aberrations may decrease due to less eyelid tension. In conclusion, the entire awareness of the effect of BoNT and the patients’ ocular condition is crucial for successful and safe results.

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“…Авторы отмечают, что регулярные инъекции ботулинического токсина А устраняли как сами спазмы века, так и субъективные негативные ощущения. Однако перед проведением данной процедуры необходимо тщательно дифференцировать первичный блефароспазм, синдром сухого глаза, конъюнктивит, кератит и миастению [35][36][37][38].…”

Section: ботулотоксин в терапии и эстетической медицинеunclassified

Effect of Cosmetic Procedures in the Periorbital Area on the Organ of Vision: Overview

et al. 2018

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Practitioners in ophthalmology in recent years often face the effects of cosmetic procedures on the paraorbital area, as well as directly on the eyelids. Such influences include botox injections in paraorbital area, blepharoplasty, eyelash extensions, injections of various fillers, etc. These manipulations are widely used and often lead to various complications of the vision organ. Eyelash extensions are a popular procedure, especially among urban, young women, but there are potential health risks from the procedure. Tattooing of eyelids leads is the cause of dysfunction of meibomian glands, which can lead to the dry eye syndrome, manifested as complaints about a feeling of chronic discomfort in the eyes. Due to the growing popularity of the age tattoo, it is necessary to pay close attention to the training of specialists who conduct this procedure. The procedure for permanent eyelid make-up should be performed after careful consideration of possible complications, and by special trained professionals. In recent years, various cosmetic procedures for rejuvenating the face plays great role, for example, injections of botulinum toxin, as well as various dermal fillers — the application of which is aimed at eliminating the aging signs. The qualification of the specialist his awareness of the occurrence of possible complications, as well as the awareness of patients who undergo this procedure is an important aspect in the application of botulinum toxin, both for therapeutic and cosmetic purposes. Of great interest are the complications associated with ischemia in the form of soft tissue necrosis and vascular occlusion caused by fillers introduction. It is reported that the frequency of vascular occlusion with dermal fillers is up to 3 per 1000 injections. The only proven elimination of soft tissue ischemia in case of a hyaluronic acid filler use is early high-dose hyaluronidase injections, since this drug helps deactivate the action of hyaluronic acid. Modern ophthalmologic practice is inextricably linked with the latest methods of modern cosmetology medicine, the results of it can effect on the functions of the whole organism as the organ of vision in particular. This fact and the specificity of possible complications arising from cosmetic procedures in the periorbital zone should be taken into account during the anamnesis collecting anamnesis, and examining patients, including preoperative preparation, and in choosing the treatment method.

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Changes in ocular higher-order aberrations following botulinum toxin treatment in patients with blepharospasm

Abstract: BTX-A is a treatment with a high potential to improve ocular surface disorders induced by BEB.

Cited by 14 publications

References 27 publications

Comparison Between Botulinum Toxin A Injection and Lacrimal Punctal Plugs for the Control of Post-LASIK Dry Eye Manifestations: A Prospective Study

Comparison Between Botulinum Toxin A Injection and Lacrimal Punctal Plugs for the Control of Post-LASIK Dry Eye Manifestations: A Prospective Study

A Review of Periocular Botulinum Neurotoxin on the Tear Film Homeostasis and the Ocular Surface Change

Effect of Cosmetic Procedures in the Periorbital Area on the Organ of Vision: Overview

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