Changes in NSE and S‑100β during the perioperative period and effects on brain injury in infants with biliary atresia undergoing parent donor liver transplantation

Yu, Hongli; Yu, Wenli; Zhu, Min; Zhang, Guicheng; Shi, Yiwei; Sun, Ying

doi:10.3892/etm.2021.10156

Cited by 3 publications

(2 citation statements)

References 31 publications

(48 reference statements)

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“…Additionally, serum S-100β protein levels were lower in the PVB group than in the general anesthesia group at the time of surgical skin incision. An early pattern of S-100ß release appears during or shortly after surgery, which generally restores within 24 h ( Yu et al, 2021 ). Biomarker concentrations decrease over time may explain the lack of changes observed in S-100β protein levels.…”

Section: Discussionmentioning

confidence: 99%

Impact of paravertebral block on perioperative neurocognitive disorder: a systematic review and meta-analysis of randomized controlled trials

Wang,

Kang

et al. 2023

Front. Aging Neurosci.

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ObjectiveTo investigate whether paravertebral block reduces postoperative delirium (POD)/delayed neurocognitive recovery (DNR) in adults after major surgery with general anesthesia.MethodsFor this systematic review and meta-analysis, we searched online databases PubMed, EMBASE, CENTRAL, and Web of Science till March 19th, 2023 to examine studies which use paravertebral block (PVB) for perioperative neurocognitive disorder. Primary and secondary outcomes were identified for the incidence of perioperative neurocognitive disorder. We did not restrict the follow-up duration of the included studies. Statistical analysis was performed to calculate mean difference (MD), Odd ratios (OR) and CI between RCTs. The quality of the evidence was assessed with the Cochrane risk of bias tool. The registration number of the study in PROSPERO is CRD42023409502. PROSPERO is an international database of prospectively registered systematic reviews. Registration provides transparency in the review process and it helps counter publication bias.ResultsTotal 1,225 patients from 9 RCTs were analyzed. The incidence of POD [Odds Ratio (OR) = 0.48, 95% CI 0.32, 0.72; p = 0.0004; I2 = 0%] and DNR [OR = 0.32, 95% CI 0.13, 0.80; p = 0.01; I2 = 0%] were significantly reduced in PVB group. The analysis showed no significant differences in postoperative MMSE scores [MD = 0.50, 95% CI −2.14, 3.15; p = 0.71; I2 = 98%]. Paravertebral block analgesia reduces pain scores and/or opioid use after surgery. Additionally, blood pressure was significantly lower in the PVB group, intraoperatively [MD = −15.50, 95% CI −20.71, −10.28; p < 0.001; I2 = 12%] and postoperatively [MD = −5.34, 95% CI −10.65, −0.03 p = 0.05; I2 = 36%]. Finally, PVB group had significantly shorter hospital stays [MD = −0.86, 95% CI −1.13, −0.59; p < 0.001; I2 = 0%].ConclusionParavertebral block analgesia may prevent perioperative POD/DNR in patients undergoing major surgery. Further research with large sample sizes is required to confirm its effectiveness.

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Section: Discussionmentioning

confidence: 99%

Impact of paravertebral block on perioperative neurocognitive disorder: a systematic review and meta-analysis of randomized controlled trials

Wang,

Kang

et al. 2023

Front. Aging Neurosci.

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“…The elevated expression of NSE was detected in peripheral blood of non-tumor patients, indicating the possibility of nervous system injury [24,25] . Due to many factors, such as decreased cardiopulmonary reserve, vascular sclerosis, abnormal coagulation function, and surgical stress, elderly patients can make the imbalance of oxygen supply and demand in perioperative brain tissue, and the metabolic disorder of nerve cells after hypoxia may be the main reason for the increased production of S100β protein and NSE [26,27] . The S100β protein and NSE in group C were signi cantly higher than those in group S on postoperative 1 day and 3 days, which may be because the uid therapy guided by SVV reduced cerebral oxygen metabolism, ensured cerebral perfusion, and reduced brain injury.…”

Section: Discussionmentioning

confidence: 99%

The effect of permissive high SVV on postoperative delirium in elderly patients in laparoscopic hepatectomy

Guo

Wang

Xue

et al. 2022

Preprint

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Backgrounds The effect of goal-directed fluid therapy (GDFT) on postoperative cognitive function in elderly patients is unknown. Therefore, we designed the present study to evaluate the effect of permissive high stroke volume variability (SVV)-mediated GDFT on postoperative delirium in elderly laparoscopic hepatectomy patients. Methods In this study, patients were randomly divided into two groups: a pilot group (group S) with SVV-guided rehydration and a control group (group C) with Central venous pressure (CVP)-guided rehydration. Group S: fluid therapy according to the target SVV value; Group C: fluid therapy according to the CVP value intraoperative parameters and postoperative outcomes were recorded for all patients. The primary outcome variables were cerebral metabolic and injury indicators, volume of access, stress and inflammatory indicators. Results Brain metabolic indexes: During operation, rSO2%max in group S was significantly lower than that in group C (7.5% vs 12.3%), and O2ER in group S was lower than that in group C at T2-4, P < 0.05. Brain injury index: S100β protein of group C at 1 day and 3 days after surgery and NSE was significantly higher than group S, P < 0.05. The incidence of POD in group S was significantly lower than that in group C (10% VS 20%), P < 0.05. The length of hospital stay was significantly less than group C (9.3 ± 1.8 VS 12.4 ± 1.9), P < 0.05. Conclusions In laparoscopic hepatectomy in the elderly, the use of permissive high SVV during hepatectomy can ensure blood perfusion of vital organs, but also ensure less tissue bleeding, reduce cerebral oxygen metabolism, reduce the inflammatory response, and reduce the occurrence of postoperative delirium, with certain safety and feasibility.

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Effects of Dexmedetomidine on Brain and Inflammatory Outcomes In Pediatric Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Hashiya

Okubo

Kato

2023

Journal of Cardiothoracic and Vascular Anesthesia

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Changes in NSE and S‑100β during the perioperative period and effects on brain injury in infants with biliary atresia undergoing parent donor liver transplantation

Cited by 3 publications

References 31 publications

Impact of paravertebral block on perioperative neurocognitive disorder: a systematic review and meta-analysis of randomized controlled trials

Impact of paravertebral block on perioperative neurocognitive disorder: a systematic review and meta-analysis of randomized controlled trials

The effect of permissive high SVV on postoperative delirium in elderly patients in laparoscopic hepatectomy

Effects of Dexmedetomidine on Brain and Inflammatory Outcomes In Pediatric Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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