Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training

Plisak, Urszula; Szczepaniak, Jarosław; Żmigrodzka, Magdalena; Giercuszkiewicz-Hecold, Beata

doi:10.1016/j.csbj.2022.12.016

Computational and Structural Biotechnology Journal

2023

DOI: 10.1016/j.csbj.2022.12.016

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Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training

Urszula Plisak¹,

Jarosław Szczepaniak²,

Magdalena Żmigrodzka³

et al.

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Cited by 6 publications

References 39 publications

(67 reference statements)

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Behaviours exhibited during training predict physical tiredness in harness trotter horses

Hennes,

Briant,

Lorcet

et al. 2024

Applied Animal Behaviour Science

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Behaviours exhibited during training predict physical tiredness in harness trotter horses

Hennes,

Briant,

Lorcet

et al. 2024

Applied Animal Behaviour Science

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Are Proteins Such as MMP2, IGF1, IL-13, and IL-1ra Valuable as Markers of Fitness Status in Racehorses? A Pilot Study

Grzędzicka,

Dąbrowska,

Kiełbik

et al. 2023

Agriculture

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In a recent study, in which more than a thousand racehorses were evaluated, three potential blood markers were selected. It was concluded that insulin-like growth factor 1 (IGF1), interleukin-1 receptor antagonist (IL-1ra), and matrix metalloproteinase 2 (MMP2) may enable the early detection of horses at risk of injuries. However, in other studies, it was suggested that cytokine concentrations indicate the athlete’s status better than mRNA expression in blood cells. Thus, the purpose of this study was to evaluate changes in IGF1, MMP-2, and novel markers such as interleukin-13 (IL-13) after exercise in horses at different fitness levels as well as after different intensities of exercise. ELISA tests were performed on thirty-one racehorses [n = 31], who were divided into an inexperienced [beginner] group [n = 20] and an experienced [advanced] group [n = 6]. In addition, differences between race and training session were evaluated to see the influence of different intensities of exercise. Blood samples were taken before and after exercise. The basal IGF1 concentration was lower in an inexperienced group (p < 0.01) as well as IL-13 (p < 0.05) in comparison to the experienced group. There were no differences between pre- and post-exercise samples, changes in multiples or between training, and racing exercises. In conclusion, the basal values of some cytokines may appear to be more beneficial in forecasting horse fitness level.

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Blood-Based Markers for Skeletal and Cardiac Muscle Function in Eventing Horses before and after Cross-Country Rides and How They Are Influenced by Plasma Volume Shift

Giers,

Bartel,

Kirsch

et al. 2023

Animals

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Horses competing in cross-country tests are subjected to high physical demands. Within the scope of this prospective longitudinal study, blood values of 20 elite eventing horses were examined before and after two- to four-star cross-country rides. The aim was to find out whether blood-based markers for skeletal muscle and cardiac muscle function change after cross-country exercise. Parameters that provide information about fluid balance, muscle enzymes, metabolites and cardiac muscle-specific markers were investigated. We developed an approach to eliminate the concentration changes caused by reduced plasma volume. Parameters were measured pre, 10 and 30 min post exercise and the next morning and were evaluated using a mixed model. Thirty minutes after exercise, most parameter concentrations changed in an exercise-dependent manner. The next morning, most exercise-related markers recovered rapidly, while creatine kinase (CK) (26% increase; p = 0.008) and lactate dehydrogenase (LDH) (15% increase; p < 0.001) showed a declining but sustained increase. Cardiac troponin I (cTnI) increased above the reference range in 40 of the 55 rides (73%) and in 18 of 20 horses in the morning after exercise.

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Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training

Cited by 6 publications

References 39 publications

Behaviours exhibited during training predict physical tiredness in harness trotter horses

Behaviours exhibited during training predict physical tiredness in harness trotter horses

Are Proteins Such as MMP2, IGF1, IL-13, and IL-1ra Valuable as Markers of Fitness Status in Racehorses? A Pilot Study

Blood-Based Markers for Skeletal and Cardiac Muscle Function in Eventing Horses before and after Cross-Country Rides and How They Are Influenced by Plasma Volume Shift

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