Changes in Noncontact Meibography and Noninvasive Tear Break-Up Time Test with Contact Lenses Usage

Fattoh, Reham; Mounir, Amr; Anbar, Mohamed; Mohammed, Osama Ali

doi:10.2147/opth.s362307

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…Two different experiments were carried out to evaluate the NIBUT assessment of Sirius+, a recently developed Placido-based topographer integrated with a Scheimpflug tomographer. Even though its clinical application has been already reported in the literature 41 – 44 , no data about its level of agreement with other devices/procedures, and repeatability is available. To clarify the discussion of the results obtained in the two experiments, the outcomes have been divided into specific paragraphs.…”

Section: Discussionmentioning

confidence: 99%

Comparing automated and manual assessments of tear break-up time using different non-invasive devices and a fluorescein procedure

Zeri,

Rizzo,

Ponzini

et al. 2024

Sci Rep

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To evaluate the agreement and repeatability of an automated topography-based method for non-invasive break-up time (NIBUT) analyses in comparison with two other NIBUT procedures, the fluorescein procedure (fBUT), and with the manual assessment with the same device. In the first experiment, a semi-randomised crossover study was performed on forty-three participants (23.1 ± 2.1 years). NIBUT measurements were collected in a randomised order, in both eyes of participants with EasyTear View + (Easytear, Rovereto), Polaris, and Sirius + (CSO, Firenze). Then a fBUT was collected. The overall measurement procedure was repeated in a further session (retest) on the same day. In a second experiment, a retrospective randomised crossover study was performed on eighty-five NIBUT videos previously recorded by the Sirius+. Two observers assessed manually the videos and the NIBUTs were compared with the automatic ones. In the first experiment, ANOVA showed a significant difference between the four measures in both eyes (p < 0.001). Significant differences were found in the paired comparisons between each NIBUT procedure and fBUT (Wicoxon; p < 0.05). Sirius+ resulted in agreement only with Polaris in the left eye. Correlations between all NIBUT procedures resulted in statistical significance in both eyes. All procedures showed very good test-rest reliability. In the second experiment, a significant correlation between automated and manual NIBUT was found, but also a significant statistical difference between the two measurements, although clinically negligible (0.3 s). The investigated NIBUT devices perform differently from each other (and from fBUT), so they cannot be considered interchangeable. The automated measure of NIBUT with Sirius+ has a negligible clinical difference compared to manual assessment on the same device.

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Section: Discussionmentioning

confidence: 99%

Comparing automated and manual assessments of tear break-up time using different non-invasive devices and a fluorescein procedure

Zeri,

Rizzo,

Ponzini

et al. 2024

Sci Rep

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“…non-contact Meibography evaluates morphological changes in the meibomian glands, such as distortion, dilation, and dropout. It can reveal detailed changes in meibomian glands (MGs); thus, it is an important tool for diagnosing meibomian glad dysfunction (MGD) and DED [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Non-contact meibography changes according to disease activity in rheumatoid arthritis cases

Mounir,

Anbar,

Awny

et al. 2023

BMC Ophthalmol

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Purpose To measure dry eye disease (DED) activity in rheumatoid arthritis (RA) patients, correlate it with the activity and duration of RA, and objectively measure the degree extent of DED in RA active cases. Methods The paper studied the meibomian gland of 30 RA cases referred by the Rheumatology Department, Sohag University Hospitals to Sohag Cornea and Refractive Center, Sohag, Egypt, by infrared non-contact meibography in the Scheimpflug topographer (Sirius, CSO, Italy) from July 2021 to July 2022. The cases fulfilled the RA classification criteria according to the 2010 American College of Rheumatology and European League and underwent full lab investigations. They were distributed to two groups based on the DAS-28 questionnaire. The patients were distributed into low to moderate activity (3.2 < score < = 5.1) and high activity groups (score > 5.1). Results This study included 60 eyes of 30 RA patients. They scored a mean age of (44 ± 10 years), number of swollen joints (3 ± 3), number of tender joints (5 ± 3), duration of disease (8 ± 4), activity of the disease measured by DAS-28 (4.4 ± 0.9), and sex (males were 9.7% vs females 90.3%). The number of swollen joints, tender joints, ESR and DAS-28 were more in the high activity group with the p-value of (0.018, 0.001, < 0.003 and < 0.004), respectively. There are no statistically significant differences between both groups as regards disease duration (p-value of 3.8). The high activity group showed significant affection regarding the mebioscore of the lower and upper lids, total mebioscore, percentage of meibomian glands in upper and lower lids, first non-invasive break-up time test (NIV-BUT) of the tear film, as well as average non-invasive break-up time test (NIavg-BUT). There were moderate correlations between the activity of the disease represented by (DAS-28) and different parameters evaluating eye dryness (meiboscore of the lower and upper lids, total meiboscore, percentage of meibomian glands in upper and lower lids, NIV-BUT of the tear film, and NIavg-BUT of the tear film). Conclusion There was no correlation with duration of RA but moderate correlations between the activity of the disease represented by (DAS-28) and different parameters evaluating eye dryness in RA patients with valuable use of noncontact Meibography to evaluate eye dryness in RA cases. Both Meiboscore and Meiboscale of Non-contact Meibography were found to be useful tools in grading of dry eye disease in different activity grades of Rheumatoid Arthritis.

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The impact of systemic isotretinoin treatment on the tear film, meibomian glands, and corneal endothelium

Demir,

Uzun

2024

Cutaneous and Ocular Toxicology

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Changes in Noncontact Meibography and Noninvasive Tear Break-Up Time Test with Contact Lenses Usage

Cited by 4 publications

References 28 publications

Comparing automated and manual assessments of tear break-up time using different non-invasive devices and a fluorescein procedure

Comparing automated and manual assessments of tear break-up time using different non-invasive devices and a fluorescein procedure

Non-contact meibography changes according to disease activity in rheumatoid arthritis cases

The impact of systemic isotretinoin treatment on the tear film, meibomian glands, and corneal endothelium

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