Changes in Non-Coding RNA in Depression and Bipolar Disorder: Can They Be Used as Diagnostic or Theranostic Biomarkers?

Gibbons, Andrew S.; Sundram, Suresh; Dean, Brian

doi:10.3390/ncrna6030033

Cited by 8 publications

(3 citation statements)

References 146 publications

(177 reference statements)

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“…Furthermore, miRNAs were also identified as potential biomarkers of BD, schizophrenia (Amoah et al, 2019;Fries et al, 2018), MDD (Gururajan et al, 2016), suicidal behaviour in BD patients (Squassina, 2020), and nausea intensity in MDD patients treated with mood stabilizers (Yrondi et al, 2020). Altogether, these results suggest that miRNAs may be potential diagnostic and predictive biomarkers in psychiatric disease (Gibbons et al, 2020).…”

Section: Micro-rnasmentioning

confidence: 85%

The molecular pathophysiology of mood disorders: From the analysis of single molecular layers to multi-omic integration

Mokhtari

Porte

Belzeaux

et al. 2022

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Next-generation sequencing now enables the rapid and affordable production of reliable biological data at multiple molecular levels, collectively referred to as "omics". To maximize the potential for discovery, computational biologists have created and adapted integrative multiomic analytical methods. When applied to diseases with traceable pathophysiology such as cancer, these new algorithms and statistical approaches have enabled the discovery of clinically relevant molecular mechanisms and biomarkers. In contrast, these methods have been much less applied to the field of molecular psychiatry, although diagnostic and prognostic biomarkers are similarly needed. In the present review, we first briefly summarize main findings from two decades of studies that investigated single molecular processes in relation to mood disorders. Then, we conduct a systematic review of multi-omic strategies that have been proposed and used more recently. We also list databases and types of data available to researchers for future work. Finally, we present the newest methodologies that have been employed for multi-omics integration in other medical fields, and discuss their potential for molecular psychiatry studies.

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Section: Micro-rnasmentioning

confidence: 85%

The molecular pathophysiology of mood disorders: From the analysis of single molecular layers to multi-omic integration

Mokhtari

Porte

Belzeaux

et al. 2022

Progress in Neuro-Psychopharmacology and Biological Psychiatry

View full text Add to dashboard Cite

show abstract

“…Therefore, any disruption or imbalance in the expression and function of miRNA networks could lead to neurological diseases and, in fact, there is accumulating evidence that miRNAs have been implicated in neurological disorders such as Parkinson's disease (PD), Alzheimer's disease (AD) and major depression disorder (MDD) (19)(20)(21). Thus, expression changes in specific miRNAs could serve as potential biomarkers for diagnostic or therapeutic targets in clinical practice (22). However, the underlying mechanisms of miRNAs in contributing to the development and progression of these neurological disorders, in particular depression, remain largely unknown.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-26a-3p rescues depression-like behaviors in male rats via preventing hippocampal neuronal anomalies

Li¹,

Fan²,

Wang³

et al. 2021

Journal of Clinical Investigation

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Depression is a neuropsychiatric disease associated with neuronal anomalies within specific brain regions. In the present study, we screened microRNA (miRNA) expression profiles in the dentate gyrus (DG) of hippocampus and found miR-26a-3p was markedly down-regulated in the rat model of depression, whereas up-regulation of miR-26a-3p within DG regions rescued the neuronal deterioration and depression-like phenotypes resulting from stress exposure, effects which appear to be mediated by the PTEN pathway.The knock-down of miR-26a-3p in DG regions of normal control rats induced depressionlike behaviors, effects which were accompanied with an activation of PTEN-PI3K/Akt signaling pathway and neuronal deterioration via suppression of autophagy, impairments in synaptic plasticity and the promotion of neuronal apoptosis. In conclusion, these results suggested that a miR-26a-3p deficits within the hippocampal DG mediated the neuronal anomalies contributing to the display of depression-like behaviors. This miRNA may serve as a potential therapeutic target for the treatment of depression.

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“…Previous studies have shown that overexpression or disorder of miRNAs is associated with the occurrence and development of many complex diseases 10 , including neurological diseases such as Parkinson's disease, Alzheimer's disease and major depressive disorder 11 . Variations in speci c miRNAs have potential as biomarkers for diagnostic or therapeutic targets in clinical practice 12 . However, the mechanisms by which miRNAs contribute to the development and progression of these neurological disorders, especially depression, remain largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Association between miR-17-92 gene promoter polymorphisms and depression in a Chinese population

Liang,

Yang,

et al. 2023

Preprint

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Background Depression is a common chronic debilitating disease with a heavy social burden. single nucleotide polymorphisms (SNPs) can affect the function of microRNAs (miRNAs), which is in turn associated with neurological diseases. However, the association between SNPs located in the promoter region of miR-17-92 and the risk of depression remains unclear. Therefore, we investigated the association between rs982873, rs9588884 and rs1813389 polymorphisms in the promoter region of miR-17-92 and the incidence of depression in a Chinese population. Methods we used GWAS (Genome-wide association study) and NCBI (National Center for Biotechnology Information) to screen three SNPs in the miR-17-92 cluster binding sites. A case-control study (including 555 cases and 541 controls) was conducted to investigate the relationship between the SNPs and risk of depression in different regions of China. The gene sequencing ii was used to genotype the collected blood samples. Results the following genotypes were significantly associated with a reduced risk of depression: rs982873 TC (TC vs TT: OR = 0.72, 95% CI, 0.54–0.96, P = 0.024; TC/CC vs TT: OR = 0.74, 95% Cl, 0.56–0.96, P = 0.025); CG genotype of rs9588884 (CG vs CC: OR = 0.74, 95% CI, 0.55–0.98, P = 0.033; CG/GG vs CC: OR = 0.75, 95% Cl, 0.57–0.98, P = 0.036); and AG genotype of rs1813389 (AG vs AA: OR = 0.75, 95% CI, 0.57-1.00, P = 0.049; AG/GG vs AA: OR = 0.76, 95% Cl, 0.59-1.00, P = 0.047). Stratified analysis showed that there was no significant correlation between the three SNPS and variables such as family history of suicidal tendency (P > 0.05). Conclusions our findings suggest that rs982873, rs9588884, and rs1813389 polymorphisms may be associated with protective factors for depression.

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Changes in Non-Coding RNA in Depression and Bipolar Disorder: Can They Be Used as Diagnostic or Theranostic Biomarkers?

Cited by 8 publications

References 146 publications

The molecular pathophysiology of mood disorders: From the analysis of single molecular layers to multi-omic integration

The molecular pathophysiology of mood disorders: From the analysis of single molecular layers to multi-omic integration

MicroRNA-26a-3p rescues depression-like behaviors in male rats via preventing hippocampal neuronal anomalies

Association between miR-17-92 gene promoter polymorphisms and depression in a Chinese population

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