Changes in NMDA receptor expression in auditory cortex after learning

Sun, Wei; Mercado, Eduardo; Wang, Ping; Shan, Xiaojun; Lee, Techung; Salvi, Richard

doi:10.1016/j.neulet.2004.10.032

Cited by 25 publications

(21 citation statements)

References 34 publications

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“…As in many reports describing neuronal-activity-induced Arc expression after sensory cognitions such as olfaction, somatosensory processing, and hearing (Sun et al 2005;Vazdarjanova et al 2006;Zou and Buck 2006), our mouse strain will be valuable for the analyses of these processes in vivo in the brain. Furthermore, using our Arc-Luc Tg mice, in the combination of optic tomography for the 3D reconstruction of the bioluminescence signal (Chaudhari et al 2005;Wang et al 2008) with conventional microMRI will reveal the regions of Arc expression in the brain during the spatial learning ) and the acquisition, consolidation, storage, and retrieval of long-term emotional memory (Sacco and Sacchetti 2010), because different brain regions are involved in these processes.…”

Section: Brainmentioning

confidence: 99%

“…Furthermore, Arc is suggested to be required in experience-dependent processes that normally establish and modify synaptic connections in the visual cortex (McCurry et al 2010). In other sensory systems, Arc expression was shown to be activated by sensory processing in olfaction (Guthrie et al 2000;Matsuoka et al 2002;Zou and Buck 2006), somatosensation Vazdarjanova et al 2006), and hearing (Sun et al 2005).…”

Section: Introductionmentioning

confidence: 99%

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Bioluminescence imaging of Arc expression enables detection of activity-dependent and plastic changes in the visual cortex of adult mice

et al. 2010

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Induction of the activity-regulated cytoskeleton-associated protein gene (Arc), one of the immediate early genes, in the brain correlates with various sensory processes, natural behaviors, and pathological conditions. Arc is also involved in synaptic plasticity during development. Thus, in vivo monitoring of Arc expression is useful for the analysis of physiological and pathological conditions in the brain. Recently, in vivo imaging of Arc expression using various green fluorescent protein-based probes has been reported; however, these probes can only be applied for the detection of fluorescence signals from superficial layers of the cortex with some autofluorescence noise. Here, we generated a novel transgenic mouse strain to monitor the neuronal-activity-dependent Arc expression using bioluminescence signals in vivo. Because of the very high sensitivity with a high signal-to-noise ratio, we detected neuronal-activity-dependent plastic changes in the bioluminescence signal intensity in the mouse visual cortex after visual deprivation, suggesting structural plasticity after peripheral lesions in adults. We also detected drastic changes in bioluminescence signals after seizure induction with kainic acid. Our novel mouse strain will be valuable for the continuous monitoring of neuronal-activity-dependent Arc expression in the brain under physiological and pathological conditions.

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Section: Brainmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioluminescence imaging of Arc expression enables detection of activity-dependent and plastic changes in the visual cortex of adult mice

et al. 2010

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“…An important arena for such rapid synaptic modulation may be the set of widespread subthreshold horizontal synaptic connections found in sensory and motor neocortex (Das and Gilbert, 1995;Huntley, 1997;Rioult-Pedotti et al, 1998;Laubach et al, 2000) which exhibit plasticity and whose synaptic eYcacy has been shown to strengthen in procedural motor learning (Rioult-Pedotti et al, 2000). Once temporarily formed, these rapid changes can be stabilized by slower concurrent mechanisms of long-term synaptic plasticity such as the formation of new functional connections through axonal sprouting, dendritic remodeling, or by long-term induction of changes in transmitter or receptor levels (Sun et al, 2005) and distribution, that take place over longer periods of time (hours and days). Additional studies will be needed to clarify the cellular mechanisms of rapid-onset cortical task-related plasticity, and its role in mediating adaptive changes in brain and behavior.…”

Section: Search For the Mechanisms Of Cortical Plasticitymentioning

confidence: 99%

Active listening: Task-dependent plasticity of spectrotemporal receptive fields in primary auditory cortex

2005

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“…It has been suggested that learning experience stabilizes synaptic modification and improves NMDA receptor expression (Quinlan et al, 2004;Sun et al, 2005). Because the ζ1 subunit mRNA shows variability during aging and could possibly be influenced by learning experience, we postulated that the overall expression of ζ1 subunits during aging is a function of differential changes in individual splice forms and its stabilization is due to learning experience influencing expression of the individual splice forms.…”

Section: Introductionmentioning

confidence: 95%

Relationship between mRNA expression of splice forms of the ζ1 subunit of the N-methyl-d-aspartate receptor and spatial memory in aged mice

Das

Magnusson

2008

Brain Research

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Age-related changes in the protein and mRNA expression of some of the splice forms of the ζ1 (NR1) subunit of the NMDA receptor have been seen in mice and rats. The present study was designed to determine whether individual splice forms of the ζ1 subunit of the NMDA receptor within prefrontal/frontal cortical regions contribute to memory deficits during aging and whether experience in learning tasks can influence the expression of the splice forms. mRNA expression of 4 splice forms (ζ1-1, ζ1-3, ζ1-a and ζ1-b) and mRNA for all known splice forms (ζ1-pan) were examined by in situ hybridization. mRNA for C-terminal splice forms, ζ1-1 (+C1 and +C2 cassettes) and ζ1-3 (+C1 and +C2′), showed significant declines during aging in several brain regions even though overall ζ1-pan mRNA expression was not significantly affected by aging. This suggests that these splice forms are more influenced by aging than the subunit as a whole. There was an increase in the expression of ζ1-a (−N1 cassette) splice form in the behaviorally-experienced old mice relative to the younger groups. Old mice with high levels of mRNA expression for the ζ1-a splice form in orbital cortex showed the best performances in the working memory task, but the poorest performances in the cued, associative learning task. These results suggest that there is a complex interaction between ζ1 splice form expression and performance of memory tasks during aging.

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Changes in NMDA receptor expression in auditory cortex after learning

Cited by 25 publications

References 34 publications

Bioluminescence imaging of Arc expression enables detection of activity-dependent and plastic changes in the visual cortex of adult mice

Bioluminescence imaging of Arc expression enables detection of activity-dependent and plastic changes in the visual cortex of adult mice

Active listening: Task-dependent plasticity of spectrotemporal receptive fields in primary auditory cortex

Relationship between mRNA expression of splice forms of the ζ1 subunit of the N-methyl-d-aspartate receptor and spatial memory in aged mice

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