Changes in neuropeptide Y immunoreactivity and transcript levels in circadian system structures of the diurnal rodent, the thirteen-lined ground squirrel

Vidal, Luis; Lugo, Nidza

doi:10.1016/j.brainres.2006.10.005

Cited by 6 publications

(4 citation statements)

References 44 publications

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“…A number of neuropeptides show daily rhythmicity (i.e., 24 h under a light‐dark cycle) in their mRNA expression (Table ), which is mainly reported for the SCN but also for other areas of the mammalian brain. Neuropeptide Y (NPY) shows a 24‐h rhythm of protein level in the rat SCN, and of mRNA in the mouse hypothalamus and diurnal squirrel SCN (Calzá et al., ; Stütz, Staszkiewicz, Ptitsyn, & Argyropoulos, ; Vidal & Lugo, ). The mRNA of Grp , Vip , Avp , Pk2 and of the peptide with histidine and isoleucine (PHI) also exhibits a 24‐h rhythm in the SCN of the rat, mouse, diurnal rodent, and/or macaque monkey (Albers et al., ; Burton et al., ; Cagampang, Yang, Nakayama, Fukuhara, & Inouye, ; Cheng et al., ; Dardente et al., ; Lambert, Machida, Smale, Nunez, & Weaver, ; Masumoto et al., ; Zoeller, Broyles, Earley, Anderson, & Alberst, ).…”

Section: Neuropeptidesmentioning

confidence: 99%

Transcriptional control of synaptic components by the clock machinery

Hannou

Roy

Roig

et al. 2019

Eur J of Neuroscience

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Circadian rhythms are generated in mammals by a central clock located in the suprachiasmatic nucleus of the hypothalamus, which regulates the homeostasis of many biological processes. At the molecular level, the regulation of circadian rhythms is under the control of transcriptional‐translational feedback loops composed of clock factors, including transcription factors. In the brain, synaptic plasticity has been shown to vary with a 24‐h rhythm. Also, when measured at a given time‐of‐day, synaptic plasticity has been observed to be disrupted by dysregulation of clock factors. This could suggest a regulation of synaptic functions by the clock machinery. Interestingly, many studies provide support for direct and indirect transcriptional regulation by core clock factors, including rhythmic gene expression, for a variety of synaptic components. Indeed, the gene of several neuropeptides, neurotransmitter regulators, receptors and transporters, ion channels, vesicle proteins, and adhesion and scaffolding molecules present evidence to be clock‐controlled. We here present, while considering different regions of the mammalian brain, an overview of the extent of the transcriptional control of synaptic components by the clock machinery.

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Section: Neuropeptidesmentioning

confidence: 99%

Transcriptional control of synaptic components by the clock machinery

Hannou

Roy

Roig

et al. 2019

Eur J of Neuroscience

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“…In fact, we have noted that when C57BL/6J mice were given access to 20% ethanol beginning 3 hours into the light cycle using DID-like procedures, consumption of ethanol was less than 2 g/kg during 4 hours, and associated BECs were less than 20 mg/dL (Lowery-Gionta et al, 2012). However, it is well recognized that there are circadian fluctuations in neurophysiological activity, including in neurochemical systems within the central nervous system that have been implicated in binge-like ethanol drinking (Mitchell et al, 1998; Sprow & Thiele, 2012; Vidal & Lugo, 2006). Thus, studies aimed at understanding the neurobiology of binge-like ethanol drinking utilizing DID procedures may yield results that are specific to the portion of the dark cycle in which measures were collected.…”

Section: Considerations For the Did Modelmentioning

confidence: 99%

“Drinking in the dark” (DID) procedures: A model of binge-like ethanol drinking in non-dependent mice

Thiele

Navarro

2014

Alcohol

212

217

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This review provides an overview of an animal model of binge-like ethanol drinking that has come to be called “drinking in the dark” (DID), a procedure that promotes high levels of ethanol drinking and pharmacologically relevant blood ethanol concentrations (BECs) in ethanol-preferring strains of mice. Originally described by Rhodes et al. (2005), the most common variation of the DID procedure, using singly housed mice, involves replacing the water bottle with a bottle containing 20% ethanol for 2 to 4 hours, beginning 3 hours into the dark cycle. Using this procedure, high ethanol drinking strains of mice (e.g., C57BL/6J) typically consume enough ethanol to achieve BECs greater than 100 mg/dL and to exhibit behavioral evidence of intoxication. This limited access procedure takes advantage of the time in the animal’s dark cycle in which the levels of ingestive behaviors are high, yet high ethanol intake does not appear to stem from caloric need. Mice have the choice of drinking or avoiding the ethanol solution, eliminating the stressful conditions that are inherent in other models of binge-like ethanol exposure in which ethanol is administered by the experimenter, and in some cases, potentially painful. The DID procedure is a high throughput approach that does not require extensive training or the inclusion of sweet compounds to motivate high levels of ethanol intake. The high throughput nature of the DID procedure makes it useful for rapid screening of pharmacological targets that are protective against binge-like drinking and for identifying strains of mice that exhibit binge-like drinking behavior. Additionally, the simplicity of DID procedures allows for easy integration into other paradigms, such as prenatal ethanol exposure and adolescent ethanol drinking. It is suggested that the DID model is a useful tool for studying the neurobiology and genetics underlying binge-like ethanol drinking, and may be useful for studying the transition to ethanol dependence.

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“…, 1990; Jhanwar‐Uniyal et al. , 1990; Shinohara et al ., 1993a), thirteen‐lined ground squirrel (Vidal & Lugo, 2006) and Mongolian gerbil (Fite et al. , 2007).…”

Section: Discussionmentioning

confidence: 99%

On the intrinsic regulation of neuropeptide Y release in the mammalian suprachiasmatic nucleus circadian clock

Glass

Guinn

Kaur

et al. 2010

Eur J of Neuroscience

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Timing of the circadian clock of the suprachiasmatic nucleus (SCN) is regulated by photic and non-photic inputs. Of these, neuropeptide Y (NPY) signaling from the intergeniculate leaflet (IGL) to the SCN plays a prominent role. Although NPY is critical to clock regulation, neither the mechanisms modulating IGL NPY neuronal activity nor the nature of regulatory NPY signaling in the SCN clock are understood, as NPY release in the SCN has never been measured. Here, microdialysis procedures for in vivo measurement of NPY were used in complementary experiments to address these questions. First, neuronal release of NPY in the hamster SCN was rhythmic under a 14L : 10D photocycle, with the acrophase soon after lights-on and the nadir at midday. No rhythmic fluctuation in NPY occurred under constant darkness. Second, a behavioral phase-resetting stimulus (wheel-running at midday that induces IGL serotonin release) acutely stimulated SCN NPY release. Third, bilateral IGL microinjection of the serotonin agonist, (+/-)-2-dipropyl-amino-8-hydroxyl-1,2,3,4-tetrahydronapthalene (8-OH-DPAT) (another non-photic phase-resetting stimulant), at midday enhanced SCN NPY release. Conversely, similar application of the serotonin antagonist, metergoline, abolished wheel-running-induced SCN NPY release. IGL microinjection of the GABA agonist, muscimol, suppressed SCN NPY release. These results support an intra-IGL mechanism whereby behavior-induced serotonergic activity suppresses inhibitory GABAergic transmission, promoting NPY activity and subsequent phase resetting. Collectively, these results confirm IGL-mediated NPY release in the SCN and verify that its daily rhythm of release is dependent upon the 14L : 10D photocycle, and that it is modulated by appropriately-timed phase-resetting behavior, probably mediated by serotonergic activation of NPY units in the IGL.

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Changes in neuropeptide Y immunoreactivity and transcript levels in circadian system structures of the diurnal rodent, the thirteen-lined ground squirrel

Cited by 6 publications

References 44 publications

Transcriptional control of synaptic components by the clock machinery

Transcriptional control of synaptic components by the clock machinery

“Drinking in the dark” (DID) procedures: A model of binge-like ethanol drinking in non-dependent mice

On the intrinsic regulation of neuropeptide Y release in the mammalian suprachiasmatic nucleus circadian clock

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