Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task

Adler, Caleb M.; Holland, Scott K.; Schmithorst, Vince; Tuchfarber, Michael J; Strakowski, Stephen M.

doi:10.1111/j.1399-5618.2004.00117.x

Cited by 181 publications

(183 citation statements)

References 64 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…Similarly, functional neuroimaging (SPECT, PET, FMRI) has consistently identified prefrontal and temporal brain activation during working memory performance (41,42,(67)(68)(69)(70)(71)(72). This study probed working memory via the N-Back paradigm adapted for FMRI and demonstrated that the same cortical structures were involved.…”

Section: Fmri In Childhood-onset Sle 4159mentioning

confidence: 80%

Functional magnetic resonance imaging assessment of cognitive function in childhood‐onset systemic lupus erythematosus: A pilot study

DiFrancesco

Holland

Ris

et al. 2007

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. To investigate changes in brain activation patterns detected by functional magnetic resonance imaging (FMRI), and the relationship between FMRI activation patterns and results of formal neuropsychological testing, in patients with childhood-onset systemic lupus erythematosus (SLE).Methods. Ten patients with childhood-onset SLE underwent formal neuropsychological testing and FMRI using 3 paradigms: a continuous performance task (CPT) to evaluate attention, an N-Back task to assess working memory, and verb generation to evaluate language processing. Composite Z maps were generated to summarize the brain activation patterns for each FMRI paradigm in patients with childhood-onset SLE and to compare these patterns with those observed in healthy controls. Between-group comparison Z maps showing differences in activation between childhood-onset SLE patients and controls were generated, using a significance level of P < 0.05 in a general linear model.Results. Compared with the control group, the childhood-onset SLE group showed statistically significant increased activation of brain areas involved in the CPT, N-Back, and verb generation tasks. In contrast, in the absence of active stimulus, e.g., during times of the paradigm control tasks, childhood-onset SLE patients consistently undersuppressed activity in the expected brain areas. Activation in selected cortical areas was found to correlate negatively with results of a subset of individual neuropsychological test scores.Conclusion. FMRI abnormalities are present in childhood-onset SLE, manifesting as an imbalance between active and inhibitory responses to an array of stimuli. Differences in brain activation patterns compared with those observed in controls suggest that childhood-onset SLE may be associated with abnormalities in white matter connectivity resulting in neuronal network dysfunction, rather than injury of specific gray matter areas.Childhood-onset systemic lupus erythematosus (SLE) is among the most severe pediatric rheumatic diseases ("pediatric" defined as onset prior to age 16). Often diagnosed in US females of minority populations, SLE is associated with significant morbidity and at least 10 times higher mortality than that of the age-matched general population (1). The reported prevalence of neuropsychiatric involvement in SLE (NPSLE) varies between 15% and 95% (2,3), and children with SLE tend to exhibit a more severe phenotype than adults (4).

show abstract

Section: Fmri In Childhood-onset Sle 4159mentioning

confidence: 80%

Functional magnetic resonance imaging assessment of cognitive function in childhood‐onset systemic lupus erythematosus: A pilot study

DiFrancesco

Holland

Ris

et al. 2007

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…In order to control for multiple comparisons and protect against type I error a clustering technique was employed. Specifically, a minimum cluster size of 15 with a significance threshold of po0.05 was used to identify activation, as previously suggested (Adler et al, 2001a(Adler et al, , 2004. Functional maps were coregistered to a structural template of averaged T1-weighted MDEFT structural images to aid interpretation.…”

Section: Discussionmentioning

confidence: 99%

“…Binary masking was applied to each image to remove pixels outside the brain. Linear and quadratic drift components in the temporal baseline of each pixel were removed using a quadratic drift correction algorithm (Adler et al, 2001a(Adler et al, , b, 2000(Adler et al, , 2004. Subjects' head movements were minimized by instructing them to remain still and by packing foam padding around their heads.…”

Section: Image Acquisitionmentioning

confidence: 99%

A Preliminary fMRI Study of Sustained Attention in Euthymic, Unmedicated Bipolar Disorder

Strakowski

Adler

Holland

et al. 2004

Neuropsychopharmacol

Self Cite

225

180

View full text Add to dashboard Cite

The symptoms of bipolar disorder suggest dysfunction of anterior limbic networks that modulate emotional behavior and that reciprocally interact with dorsal attentional systems. Bipolar patients maintain a constant vulnerability to mood episodes even during euthymia, when symptoms are minimal. Consequently, we predicted that, compared with healthy subjects, bipolar patients would exhibit abnormal activation of regions of the anterior limbic network with corresponding abnormal activation of other cortical areas involved in attentional processing. In all, 10 unmedicated euthymic bipolar patients and 10 group-matched healthy subjects were studied with fMRI while performing the Continuous Performance Task-Identical Pairs version (CPT-IP). fMRI scans were obtained on a 3.0 T Bruker system using an echo planar imaging (EPI) pulse sequence, while subjects performed the CPT-IP and a control condition to contrast group differences in regional brain activation. The euthymic bipolar and healthy subjects performed similarly on the CPT-IP, yet showed significantly different patterns of brain activation. Specifically, bipolar patients exhibited increased activation of limbic, paralimbic, and ventrolateral prefrontal areas, as well as visual associational cortices. Healthy subjects exhibited relatively increased activation in fusiform gyrus and medial prefrontal cortex. In conclusion, these differences suggest that bipolar patients exhibit overactivation of anterior limbic areas with corresponding abnormal activation in visual associational cortical areas, permitting successful performance of an attentional task. Since the differences occurred in euthymia, they may represent trait, rather than state, abnormalities of brain function in bipolar disorder.

show abstract

“…3 However, some recent investigations and the present results provide evidence of hyperactivation of prefrontal cortex or 'hyperfrontality' during working memory tasks in patients with mood disorder. 25,47 The association between task performance and frontal activation is not consistent. In some studies showing hypofrontality, the patients' cognitive or working memory performance was much poorer than that of the controls 28,30,48 and in the other studies the patients' performance was not significantly different from that of the controls.…”

Section: Working Memory In Depression K Matsuo Et Almentioning

confidence: 97%

“…In some studies showing hypofrontality, the patients' cognitive or working memory performance was much poorer than that of the controls 28,30,48 and in the other studies the patients' performance was not significantly different from that of the controls. 26,49 One study demonstrating hyperfrontality showed poor performance in the patients on the n-back task (n > 0) compared to controls, 47 and the other showed no difference in cognitive task performance between the patients and the healthy controls. 25 The MDD patients in our study showed this pattern of hyperfrontality without impaired cognitive task performance.…”

Section: Working Memory In Depression K Matsuo Et Almentioning

confidence: 99%

Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder

et al. 2006

View full text Add to dashboard Cite

The prefrontal cortex, a part of the limbic-thalamic-cortical network, participates in regulation of mood, cognition and behavior and has been implicated in the pathophysiology of major depressive disorder (MDD). Many neuropsychological studies demonstrate impairment of working memory in patients with MDD. However, there are few functional neuroimaging studies of MDD patients during working memory processing, and most of the available ones included medicated patients or patients with both MDD and bipolar disorder. We used functional magnetic resonance imaging (fMRI) to measure prefrontal cortex function during working memory processing in untreated depressed patients with MDD. Fifteen untreated individuals with Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition recurrent MDD (mean age7s.d. = 34.3711.5 years) and 15 healthy comparison subjects (37.7712.1 years) matched for age, sex and race were studied using a GE/Elscint 2T MR system. An echo-planar MRI sequence was used to acquire 24 axial slices. The n-back task (0-back, 1-back and 2-back) was used to elicit frontal cortex activation. Data were analyzed with a multiple regression analysis using the FSL-FEAT software. MDD patients showed significantly greater left dorsolateral cortex activation during the n-back task compared to the healthy controls (P < 0.01), although task performance was similar in the two groups. Furthermore, the patients showed significant anterior cingulate cortex activation during the task, but the comparison subjects did not (P < 0.01). This study provides in vivo imaging evidence of abnormal frontolimbic circuit function during working memory processing in individuals with MDD.

show abstract

Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task

Cited by 181 publications

References 64 publications

Functional magnetic resonance imaging assessment of cognitive function in childhood‐onset systemic lupus erythematosus: A pilot study

Functional magnetic resonance imaging assessment of cognitive function in childhood‐onset systemic lupus erythematosus: A pilot study

A Preliminary fMRI Study of Sustained Attention in Euthymic, Unmedicated Bipolar Disorder

Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder

Contact Info

Product

Resources

About