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2013
DOI: 10.1271/bbb.130131
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Changes in NAD Content Induced by Nicotinic Acid-Related Compounds in K562 Cells during Differentiation

Abstract: Two nicotinic acid-related compounds were found to induce erythroid differentiation in K562 cells. We investigated the changes in nicotinamide adenine dinucleotide (NAD) content induced by nicotinic acid-related compounds during differentiation. The NAD content was reduced by a treatment with nicotinic acid and isonicotinic acid. These results provide important clues toward elucidating the erythroid differentiation mechanism.

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