Changes in myosin light chains in the rat soleus after thyroidectomy

Johnson, Margaret; Mastaglia, Frank; Montgomery, A.; Pope, Brian; Weeds, Alan G.

doi:10.1016/0014-5793(80)80080-9

Cited by 46 publications

(14 citation statements)

References 15 publications

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“…No consistent effect on fibre types has been reported. The fast-to-slow transformation of the fibres is reflected in a change of the myosin light chain pattern; fast myosin is almost completely lost (JOHNSON et al 1980). The biochemically determined myosin ATPase activity and the number of type II fibres in soleus muscles of thyroidectomized rats increases after administration of thyroid hormone (IANuzzo et al 1977).…”

Section: Non-neural Influences On Fibre Typesmentioning

confidence: 99%

Skeletal Muscle

Schmalbruch

1985

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Section: Non-neural Influences On Fibre Typesmentioning

confidence: 99%

Skeletal Muscle

Schmalbruch

1985

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“…Normal (euthyroid) slow-twitch rat soleus muscle can be slowed or speeded by lowering or raising the level of circulating thyroid hormones. Low levels (hypothyroid) prolong isometric contractions, reduce isotonic shortening velocity (Montgomery, 1984) and respectively decrease and increase the proportions of type 11A fast-twitch and slow-twitch type I fibres (Johnson et al 1980). Increased levels of triiodothyronine (T3) (hyperthyroid) produce the opposite effects.…”

Section: Pmentioning

confidence: 99%

Proceedings of the Physiological Society, 5‐6 January 1990, Liverpool Meeting: Communications

1990

The Journal of Physiology

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The acid-secreting portion of the avian gut, the proventriculus, contains two representatives of the gastrin-releasing peptide group which have been chemically characterized as a 27-residue (GRP-27) peptide and its C-terminal hexapeptide (GRP-6) (McDonald et al. 1980;Campbell et al. 1989). We report here that GRP-27 is a potent stimulant of the exocrine pancreas, and that it might mediate proventriculus-pancreatic reflexes.Turkeys (1-0-2-5 kg) were anaesthetized with urethane (1P5 g kg-', i.P.). A wing vein was cannulated for injections, and the major pancreatic duct was cannulated for collection of pancreatic juice. The proventriculus was cannulated at either end to enable perfusion of the lumen with 4-5 % meat peptone II. Chicken GRP-27 was a potent stimulant of both the rate of flow and rate of protein secretion from the pancreas in doses from 6 to 100 pmol kg-1 i.v., but GRP-6 was virtually inactive at a dose of 6400 pmol kg-' i.v. A GRP antagonist (CH3)2-CHCO-His-Trp-Ala-Val-DAla-His-Leu-NHCH2 (Camble et al. 1989), in a dose of 50 ,tg kg-', i.v., reduced the peak increment in protein output in response to 6 pmol kg-' of GRP-27 from 1-46+0-36 (mean s.E., n = 6) to 0-38+0-18 mg g-1 gland-1 per 10 min (P < 0-05, t test). Distension of the proventriculus in atropinized animals (50 /Ig kg-') for 10 min with peptone stimulated pancreatic protein secretion by 0-71 +0-12 mg g-1 gland-1 per 10 min (n = 5). This response was reduced to 0-15+0-04 (P < 0-05) after administration of the GRP antagonist. We conclude that GRP-27 is a good candidate for mediating peptone-evoked proventriculus-pancreatic reflexes.

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“…These studies indicate that the speeds of contraction and relaxation in skeletal muscle are related to the thyroid hormone status and that the changes in physiological properties of the muscles observed when this status is altered are associated with appropriate changes in the proportion of type I and type II fibres [6,7,9,10]. The modifications that occur in the myosin light chain composition after thyroidectomy correlate well with the changes in fibre types and physiological properties [8,10].…”

Section: Introductionmentioning

confidence: 97%

“…The effects of thyroid hormones on the properties of muscle in both experimental and clinical situations are well-documented [1][2][3][4][5][6][7][8][9]. These studies indicate that the speeds of contraction and relaxation in skeletal muscle are related to the thyroid hormone status and that the changes in physiological properties of the muscles observed when this status is altered are associated with appropriate changes in the proportion of type I and type II fibres [6,7,9,10].…”

Section: Introductionmentioning

confidence: 99%