Changes in Muscle Thickness and Echo Intensity in Chronic Stroke Survivors: A 2-Year Longitudinal Study

Monjo, Hiroki; Fukumoto, Yoshihiro; Asai, Tsuyoshi; Oshima, Koichiro; Kubo, Hajime; Tajitsu, Hirotsugu; Koyama, Shota

doi:10.3988/jcn.2022.18.3.308

Cited by 9 publications

(10 citation statements)

References 28 publications

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“…Previous research has reported that muscle EI is negatively correlated with MT in older adults [ 26 ]. Another study reported that changes in muscle EI were significantly associated with changes in BMI [ 27 ]. These findings imply that muscle EI has a more complicated relationship with MT and other demographic factors.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of muscle ultrasound in appendicular skeletal muscle mass estimation for sarcopenia assessment

et al. 2023

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The measurement of skeletal muscle mass is essential for the diagnosis of sarcopenia. Muscle ultrasonography has emerged as a useful tool for evaluating sarcopenia because it can be used to assess muscle quality and quantity. This study investigated whether muscle ultrasonography is effective for estimating appendicular skeletal muscle mass (ASM) and screening for sarcopenia. This study prospectively enrolled 212 healthy volunteers aged 40–80 years. ASM was measured using the bioelectrical impedance analysis. Muscle thickness (MT) and echo-intensity (EI) were measured in four muscles (biceps brachii, BB; triceps brachii, TB; rectus femoris, RF; biceps femoris, BF) on the dominant hand. A hold-out cross-validation method was used to develop and validate the ASM prediction equation. In the model development group, the ASM prediction equations were deduced as follows: estimated ASM for men (kg) = 0.167 × weight (kg) + 0.228 × height (cm) + 0.143 × MT of BF (mm)– 0.822 × EI to MT ratio of BB– 28.187 (R2 = 0.830) and estimated ASM for women (kg) = 0.115 × weight + 0.215 × height (cm) + 0.139 × MT of RF–0.638 × EI to MT ratio of BB– 23.502 (R2 = 0.859). In the cross-validation group, the estimated ASM did not significantly differ from the measured ASM in both men (p = 0.775; intraclass correlation coefficient [ICC] = 0.948) and women (p = 0.516; ICC = 0.973). In addition, multiple logistic regression analysis revealed that the ratios of EI to MT in the BF and RF muscles in men and MT in the BB muscle in women could be valuable parameters for sarcopenia screening. Therefore, our study suggests that muscle ultrasound could be an effective tool for estimating ASM and screening sarcopenia.

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Section: Discussionmentioning

confidence: 99%

Usefulness of muscle ultrasound in appendicular skeletal muscle mass estimation for sarcopenia assessment

et al. 2023

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“…Despite the current assessment indicators being able to reflect behavioral alterations, they do not precisely reflect skeletal muscle changes after stroke. According to published clinical and basic studies, skeletal muscle injury after stroke primarily occurs in the transverse muscle [ 47 ]. Therefore, we refer to the studies from transverse muscle atrophy [ 48 ], including the treadmill and pull tests [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Ischemic Stroke Induces Skeletal Muscle Damage and Alters Transcriptome Profile in Rats

Zhang

et al. 2023

JCM

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To establish pathological features of skeletal muscle post-stroke and to provide a background for promising interventions. Adult male SD rats were selected and randomly divided into a control group, a sham group, and a middle cerebral artery occlusion (MCAO) group. The tolerance and capability of exercise were separately collected on days 1, 3, 5, and 7 after the MCAO operation. The neurological deficits, brain infarct volume, soleus histopathology, mRNA-seq analysis, flow cytometry, immunofluorescence, and protein expression analysis were performed on the seventh day. Rats in the MCAO group showed that soleus tissue weight, pulling force, exercise capacity, endurance, and muscle structure were significantly decreased. Moreover, the RNA sequencing array revealed that mitochondrial-mediated autophagy was the critical pathological process, and the result of transcriptomic findings was confirmed at the translational level. The mitochondrial membrane potential and the mfn2 and p62 protein expression were decreased, and the Beclin-1, ATG5, Parkin, PINK1, LC3B, and Drp1 expression were upregulated; these results were consistent with immunohistochemistry. This is the first report on the pathological features of limbic symptoms on day 7 after MCAO surgery in rats. In addition, we further confirmed that autophagy is one of the main causative mechanisms of reduced muscle function after stroke.

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“…31 Moreover, several longitudinal studies revealed that the changes in EI predict functional recovery or affect physical activity and clinical outcomes in community-dwelling older adults or patients with neuromuscular diseases. 28,[53][54][55] In consideration of the above-mentioned findings, muscle US was able to assess the quantitative and qualitative changes in skeletal muscle efficiently and better and could be an alternative to ASMI.…”

Section: Discussionmentioning

confidence: 99%

The Muscle Thickness Assessment Using Ultrasonography is a Useful Alternative to Skeletal Muscle Mass by Bioelectrical Impedance Analysis

Isaka¹,

Sugimoto²,

Akasaka³

et al. 2022

CIA

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Purpose Muscle mass, a key index for the diagnosis of sarcopenia, is currently assessed using the appendicular skeletal muscle mass index (ASMI) by bioelectrical impedance analysis (BIA). Muscle thickness (MT) assessed by ultrasonography (US) may be a better determinant and/or predictor of muscle condition than ASMI. Thus, we compared it to the ASMI determined by the BIA. Patients and Methods Our study included 165 ambulatory older adults (84 males, 81 females, mean age: 76.82 years). The ASMI by the BIA method, MT by US, and the distribution of body mass index (BMI) and body fat percentage (BFP) were examined using defined values for men and women. These were used as the basis for examining the association of MT and ASMI with handgrip strength (HGS), leg muscle strength (LMS), gait speed (GS), and echo intensity (EI). We compared HGS, LMS, GS, and EI for high and low ASMI among lower BMI or BFP. The same was also done for MT assessed by US. Results MT, as well as ASMI, was strongly associated with HGS and LMS. There was a correlation between MT and GS and EI but not between ASMI and GS and EI. There were significant differences in the prevalence between high ASMI and high MT or low ASMI and low MT in those with lower BMI or BFP. In non-overweight participants, HGS, LMS, GS, and EI were significantly higher in those with high MT than in those with low MT; however, there were no significant differences in them between those with high and low ASMI. Conclusion In the non-overweight group, the MT assessment by US showed a stronger relationship to muscle strength and muscle quality than the ASMI assessment by BIA. The MT assessment using US is a useful alternative to BIA-assessed ASMI, especially in non-overweight participants.

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Changes in Muscle Thickness and Echo Intensity in Chronic Stroke Survivors: A 2-Year Longitudinal Study

Cited by 9 publications

References 28 publications

Usefulness of muscle ultrasound in appendicular skeletal muscle mass estimation for sarcopenia assessment

Usefulness of muscle ultrasound in appendicular skeletal muscle mass estimation for sarcopenia assessment

Ischemic Stroke Induces Skeletal Muscle Damage and Alters Transcriptome Profile in Rats

The Muscle Thickness Assessment Using Ultrasonography is a Useful Alternative to Skeletal Muscle Mass by Bioelectrical Impedance Analysis

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