Changes in muscle compartment pressure after cardiopulmonary bypass

Símonardóttir, Líney; Torfason, Bjarni; Stefánsson, Einar; Magnússon, Jónas

doi:10.1191/0267659106pf861oa

Cited by 3 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whether the cardiac actions of these techniques are directly due to a reduction in inflammatory response is not presently known. For example, there are haemodynamic and osmotic changes which can result in oedema in the heart 23 .…”

Section: Cardioprotective Strategies During Open Heart Surgery: Key Approachesmentioning

confidence: 99%

Cardioplegic strategies to protect the hypertrophic heart during cardiac surgery

et al. 2011

View full text Add to dashboard Cite

Cardioplegic arrest and cardiopulmonary bypass are key triggers of myocardial injury during aortic valve surgery. Cardioplegic ischaemic arrest is associated with disruption to metabolic and ionic homeostasis in cardiomyocytes. These changes predispose the heart to reperfusion injury caused by elevated intracellular reactive oxygen species and calcium. Cardiopulmonary bypass is associated with an inflammatory response that can generate systemic oxidative stress which, in turn, provokes further damage to the heart. Techniques of myocardial protection are routinely applied to all hearts, irrespective of their pathology, although different cardiomypathies respond differently to ischaemia and reperfusion injury. In particular, the efficacy of cardioprotective interventions used to protect the hypertrophic heart in patients with aortic valve disease remains controversial. This review will describe key cellular changes in hypertrophy, response to ischaemia and reperfusion and cardioplegic arrest and highlight the importance of optimising cardioprotective strategies to suit hypertrophic hearts.

show abstract

Section: Cardioprotective Strategies During Open Heart Surgery: Key Approachesmentioning

confidence: 99%

Cardioplegic strategies to protect the hypertrophic heart during cardiac surgery

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Whether the cardiac actions of these techniques and pharmacological agents are directly due to a reduction in inflammatory response remains to be determined, as this issue is complicated by the fact that there are several myocardial factors (changes) that could influence reperfusion injury following on‐pump cardiac surgery. For example there are haemodynamic and osmotic changes that can result in oedema in the heart ( Simonardottir et al , 2006 ).…”

Section: Cardioprotective Strategies During Open‐heart Surgerymentioning

confidence: 99%

Inflammatory response and cardioprotection during open‐heart surgery: the importance of anaesthetics

Suleiman

Zacharowski

Angelini

2008

British J Pharmacology

137

108

View full text Add to dashboard Cite

Open-heart surgery triggers an inflammatory response that is largely the result of surgical trauma, cardiopulmonary bypass, and organ reperfusion injury (e.g. heart). The heart sustains injury triggered by ischaemia and reperfusion and also as a result of the effects of systemic inflammatory mediators. In addition, the heart itself is a source of inflammatory mediators and reactive oxygen species that are likely to contribute to the impairment of cardiac pump function. Formulating strategies to protect the heart during open heart surgery by attenuating reperfusion injury and systemic inflammatory response is essential to reduce morbidity. Although many anaesthetic drugs have cardioprotective actions, the diversity of the proposed mechanisms for protection (e.g. attenuating Ca 2 þ overload, anti-inflammatory and antioxidant effects, pre-and post-conditioning-like protection) may have contributed to the slow adoption of anaesthetics as cardioprotective agents during open heart surgery. Clinical trials have suggested at least some cardioprotective effects of volatile anaesthetics. Whether these benefits are relevant in terms of morbidity and mortality is unclear and needs further investigation. This review describes the main mediators of myocardial injury during open heart surgery, explores available evidence of anaesthetics induced cardioprotection and addresses the efforts made to translate bench work into clinical practice.

show abstract

“…Hemodilution seems to have little effect on cerebral and kidney water accumulation, while it has a greater effect in skeletal muscle, gastrointesti-nal organs, and the heart. 37,60 Mannitol and albumin are effective in reducing muscle compartment pressures after cardiac surgery, 61 but they do not have a significant impact on water content of the intestines, stomach, liver, or myocardium. 62 Increasing the COP of prime should be a focus of attempts to decrease edema in adults and pediatric patients, although additional strategies seem to be warranted for optimal reduction in edema.…”

Section: Decreased Plasma Colloid Osmotic Pressure (Pcop)mentioning

confidence: 99%

Cardiopulmonary bypass and edema: physiology and pathophysiology

Hirleman

Larson

2008

Perfusion

View full text Add to dashboard Cite

Edema is a common morbidity following cardiopulmonary bypass (CPB) and can result in injury to many organs, including the heart, lungs, and brain. Generalized edema is also common and can lead to increased post-operative hospital stay and other morbidities. Pediatric patients are more susceptible to post-CPB edema and the consequences are more severe for this population. Hemodilution and systemic inflammatory responses are two suspected causes of CPB-related edema; however, the mechanisms involved are far from understood. Also, the common strategies to improve edema have not been completely successful and there is a need for new strategies at maintaining a fluid balance of patients as close to physiological as possible, especially for pediatric patients. An integrative approach to understanding edema is necessary as the forces involved in fluid homeostasis are dynamic and interdependent. Therefore, this review will focus on the physiology of fluid homeostasis and the pathologies of fluid shifts during CPB which lead to general edema as well as tissue-specific edema.

show abstract

Changes in muscle compartment pressure after cardiopulmonary bypass

Abstract: Lower leg muscle compartment pressure and intraocular pressure behave differently during and after cardiac surgery. Albumin and mannitol added to the pump prime decreases muscle compartment pressure after cardiac surgery.

Cited by 3 publications

References 29 publications

Cardioplegic strategies to protect the hypertrophic heart during cardiac surgery

Cardioplegic strategies to protect the hypertrophic heart during cardiac surgery

Inflammatory response and cardioprotection during open‐heart surgery: the importance of anaesthetics

Cardiopulmonary bypass and edema: physiology and pathophysiology

Contact Info

Product

Resources

About