Changes in morphometry and association between whole-body fatty acids and steroid hormone profiles in relation to bioaccumulation patterns in salmon larvae exposed to perfluorooctane sulfonic or perfluorooctane carboxylic acids

Arukwe, Augustine; Cangialosi, Maria Vittoria; Letcher, Robert J.; Rocha, Eduardo; Mortensen, Anne S.

doi:10.1016/j.aquatox.2012.12.026

Cited by 18 publications

(7 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased liver weight found at the 1000 μg PFOA/egg dose is consistent with observations in mice [ 50 ] and salmon larvae [ 51 ]. Neither PFOA nor GW7647 caused any major changes in plasma lipid levels, suggesting that lipid concentrations in plasma may not be a sensitive indicator of PPARα-activation in chicken embryos following short-term exposure.…”

Section: Discussionsupporting

confidence: 90%

“…Oral exposure of adult mice to PFOA resulted in rapid reduction of body- and adipose tissue weight, increase in absolute and relative liver weight, and decrease in serum cholesterol and triacylglycerol levels [ 50 , 52 ]. Decreased serum cholesterol and triacylglycerol levels have also been observed following perinatal exposure of mice to PFOA [ 53 ], and whole body levels of cholesterol were decreased in PFOA-exposed salmon larvae [ 51 ]. In humans, PFOA has on the other hand been associated with increased serum cholesterol and triacylglycerol levels at high environmental or occupational exposure [ 54 – 56 ] as well as at background exposure experienced by the general population [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA) and Agonists to Peroxisome Proliferator-Activated Receptors

et al. 2015

View full text Add to dashboard Cite

Untargeted metabolic profiling of body fluids in experimental animals and humans exposed to chemicals may reveal early signs of toxicity and indicate toxicity pathways. Avian embryos develop separately from their mothers, which gives unique possibilities to study effects of chemicals during embryo development with minimal confounding factors from the mother. In this study we explored blood plasma and allantoic fluid from chicken embryos as matrices for revealing metabolic changes caused by exposure to chemicals during embryonic development. Embryos were exposed via egg injection on day 7 to the environmental pollutant perfluorooctanoic acid (PFOA), and effects on the metabolic profile on day 12 were compared with those caused by GW7647 and rosiglitazone, which are selective agonists to peroxisome-proliferator activated receptor α (PPARα) and PPARγ, respectively. Analysis of the metabolite concentrations from allantoic fluid by Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA) showed clear separation between the embryos exposed to GW7647, rosiglitazone, and vehicle control, respectively. In blood plasma only GW7647 caused a significant effect on the metabolic profile. PFOA induced embryo mortality and increased relative liver weight at the highest dose. Sublethal doses of PFOA did not significantly affect the metabolic profile in either matrix, although single metabolites appeared to be altered. Neonatal mortality by PFOA in the mouse has been suggested to be mediated via activation of PPARα. However, we found no similarity in the metabolite profile of chicken embryos exposed to PFOA with those of embryos exposed to PPAR agonists. This indicates that PFOA does not activate PPAR pathways in our model at concentrations in eggs and embryos well above those found in wild birds. The present study suggests that allantoic fluid and plasma from chicken embryos are useful and complementary matrices for exploring effects on the metabolic profile resulting from chemical exposure during embryonic development.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA) and Agonists to Peroxisome Proliferator-Activated Receptors

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In the present study, increased high unsaturated long chain-PUFA composition concomitant with decreased saturated fatty acid (such as palmitic acid) composition was observed in mice epididymides treated with PFOA. Fatty acid profile disruption has also been found following continuous PFOS and PFOA exposure on freshly fertilized eggs (Arukwe et al, 2013). Cellular PUFA components are associated with enzymes, which convert short chain- p-AKT (Ser473), and AKT.…”

Section: Discussionmentioning

confidence: 97%

Perfluorooctanoic acid exposure alters polyunsaturated fatty acid composition, induces oxidative stress and activates the AKT/AMPK pathway in mouse epididymis

Pan

Sheng

et al. 2016

Chemosphere

View full text Add to dashboard Cite

“…Toxicology studies have suggested that PFAS can stimulate the glucocorticoid secretion directly in the human adrenocortical cells (H295R) 24 and salmon embryos. 61 Second, PFAS can regulate the fetal glucocorticoid levels by influencing the expression level and activity of the placental 11β hydroxysteroid dehydrogenase-2 (11β-HSD2) and corticotropin-releasing hormone (CRH). 25,26 Cortisol is the most important glucocorticoid in human; maternal cortisol could crosses the placenta to nourish the fetal growth.…”

Section: Influence Of Glucocorticoid On the Association Between Pfas ...mentioning

confidence: 99%

Fetal Glucocorticoid Mediates the Association between Prenatal Per- and Polyfluoroalkyl Substance Exposure and Neonatal Growth Index: Evidence from a Birth Cohort Study

Cai

Mohammed

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

Glucocorticoid plays a key role in the growth and organ maturation of fetus. However, the effect of glucocorticoid on the association between per-and polyfluoroalkyl substance (PFAS) exposure and fetal growth is still unknown. We detected cord cortisol (active glucocorticoid in human) and 34 PFAS concentrations in the maternal serum samples, which were collected from 202 mother-fetus pairs in the Maoming Birth Cohort from 2015 to 2018. The mediation effect of cord cortisol on the association between maternal PFAS and the neonatal growth index (NGI) was estimated. We found that higher PFAS concentrations were associated with lower NGI in terms of ponderal index, birth weight (BW), head circumference (HC), and its z-scores (BWZ and HCZ) (P < 0.05). Fetal cortisol could mediate 12.6−27.3% of the associations between PFAS and NGI. Specifically, cord cortisol mediated the association between branched perfluorooctane sulfonate (branched PFOS) and HCZ by 20.4% and between perfluorooctanoate (PFOA) and HCZ by 27.3%. Our findings provide the first epidemiological data evincing that fetal cortisol could mediate the association between prenatal PFAS exposure and fetal growth. Further investigations are recommended to elucidate the interactions among cord cortisol, PFAS, and fetal growth.

show abstract

Changes in morphometry and association between whole-body fatty acids and steroid hormone profiles in relation to bioaccumulation patterns in salmon larvae exposed to perfluorooctane sulfonic or perfluorooctane carboxylic acids

Cited by 18 publications

References 94 publications

Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA) and Agonists to Peroxisome Proliferator-Activated Receptors

Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA) and Agonists to Peroxisome Proliferator-Activated Receptors

Perfluorooctanoic acid exposure alters polyunsaturated fatty acid composition, induces oxidative stress and activates the AKT/AMPK pathway in mouse epididymis

Fetal Glucocorticoid Mediates the Association between Prenatal Per- and Polyfluoroalkyl Substance Exposure and Neonatal Growth Index: Evidence from a Birth Cohort Study

Contact Info

Product

Resources

About