Changes in mononuclear peripheral blood cells in cattle with foot-and-mouth disease

Sigal, Luis J.; Gómez, Gonzalo Melo; Braun, Marta

doi:10.1016/0165-2427(92)90111-3

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…In this study, we report that CD14 + monocyte frequency increases following inoculation of cattle with both FMDV O1 Manisa and A24 Cruzeiro. These results are in agreement with a previous report in cattle which demonstrated that blood monocyte numbers increased following vaccination and challenge with FMDV [ 45 ]. An increase in blood monocytes may function as a reservoir for cDC.…”

Section: Discussionsupporting

confidence: 94%

Effect of Foot-and-Mouth Disease Virus Infection on the Frequency, Phenotype and Function of Circulating Dendritic Cells in Cattle

et al. 2016

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Foot-and-mouth disease virus (FMDV) is a highly contagious virus that causes one of the most devastating diseases in cloven-hoofed animals. Disease symptoms develop within 2 to 3 days of exposure and include fever and vesicular lesions on the tongue and hooves. Dendritic cells (DC) play an essential role in protective immune responses against pathogens. Therefore, investigating their role during FMDV infection would lead to a better understanding of host-pathogen interactions. In this study, following infection of cattle with FMDV, we investigated the frequency and function of conventional (cDC) and plasmacytoid DC (pDC) in blood by using multi-color flow cytometry. We show that the frequency of cDC and pDC increased following FMDV infection and peaked 3 to 4 days post-infection. During peak viremia, the cattle became lymphopenic, the expression of MHC class II molecules on cDC and pDC was dramatically down-regulated, the processing of exogenous antigen by cDC and pDC was impaired, and there was an increase in IL-10 production by DC and monocytes. Notably, after clearance of FMDV from the blood, MHC class II expression returned to pre-infection levels. Altogether, our study demonstrates that in cattle, FMDV inhibits the function of DC, thereby retarding the initiation of adaptive immune responses, potentially enhancing virus shedding during the acute phase of infection.

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Section: Discussionsupporting

confidence: 94%

Effect of Foot-and-Mouth Disease Virus Infection on the Frequency, Phenotype and Function of Circulating Dendritic Cells in Cattle

et al. 2016

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“…Implications of these observations favor a model in which Mφ act as transporters and disseminators of viable virions to distant sites of the body where the virus can infect and replicate in other cells. On the other hand, in cattle, CD14+ monocyte frequency increases following inoculation with FMDV ( Sei et al, 2016 ), consistently with previous reports demonstrating that the number of blood monocytes augment following vaccination and challenge with FMDV ( Sigal et al, 1992 ). In this case, blood monocytes may function as cDCs, in which the reduced levels of MHC-II compromise antigen presentation.…”

Section: Fmdv Pathogenesis In Cattle and Swinesupporting

confidence: 90%

The Different Tactics of Foot-and-Mouth Disease Virus to Evade Innate Immunity

et al. 2018

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Like all pathogens, foot-and-mouth disease virus (FMDV) is recognized by the immune system inducing a heightened immune response mainly mediated by type I and type III IFNs. To overcome the strong antiviral response induced by these cytokines, FMDV has evolved many strategies exploiting each region of its small RNA genome. These include: (a) inhibition of IFN induction at the transcriptional and translational level, (b) inhibition of protein trafficking; (c) blockage of specific post-translational modifications in proteins that regulate innate immune signaling; (d) modulation of autophagy; (e) inhibition of stress granule formation; and (f) in vivo modulation of immune cell function. Here, we summarize and discuss FMDV virulence factors and the host immune footprint that characterize infection in cell culture and in the natural hosts.

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“…Four days after challenge, and two days after circulating lymphocyte counts had started to increase, monocyte counts rose sharply and remained high (approximately 50 % above baseline) for several days. Sigal et al [ 77 ] have previously reported a similar increase of monocytes in FMDV-vaccinated animals 1 week after challenge.…”

Section: Discussionmentioning

confidence: 64%

Systemic immune response and virus persistence after foot-and-mouth disease virus infection of naïve cattle and cattle vaccinated with a homologous adenovirus-vectored vaccine

et al. 2016

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BackgroundIn order to investigate host factors associated with the establishment of persistent foot-and-mouth disease virus (FMDV) infection, the systemic response to vaccination and challenge was studied in 47 steers. Eighteen steers that had received a recombinant FMDV A vaccine 2 weeks earlier and 29 non-vaccinated steers were challenged by intra-nasopharyngeal deposition of FMDV A24. For up to 35 days after challenge, host factors including complete blood counts with T lymphocyte subsets, type I/III interferon (IFN) activity, neutralizing and total FMDV-specific antibody titers in serum, as well as antibody-secreting cells (in 6 non-vaccinated animals) were characterized in the context of viral infection dynamics.ResultsVaccination generally induced a strong antibody response. There was a transient peak of FMDV-specific serum IgM in non-vaccinated animals after challenge, while IgM levels in vaccinated animals did not increase further. Both groups had a lasting increase of specific IgG and neutralizing antibody after challenge.Substantial systemic IFN activity in non-vaccinated animals coincided with viremia, and no IFN or viremia was detected in vaccinated animals. After challenge, circulating lymphocytes decreased in non-vaccinated animals, coincident with viremia, IFN activity, and clinical disease, whereas lymphocyte and monocyte counts in vaccinated animals were unaffected by vaccination but transiently increased after challenge. The CD4+/CD8+ T cell ratio in non-vaccinated animals increased during acute infection, driven by an absolute decrease of CD8+ cells.ConclusionsThe incidence of FMDV persistence was 61.5 % in non-vaccinated and 54.5 % in vaccinated animals. Overall, the systemic factors examined were not associated with the FMDV carrier/non-carrier divergence; however, significant differences were identified between responses of non-vaccinated and vaccinated cattle.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-016-0838-x) contains supplementary material, which is available to authorized users.

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Changes in mononuclear peripheral blood cells in cattle with foot-and-mouth disease

Cited by 5 publications

References 9 publications

Effect of Foot-and-Mouth Disease Virus Infection on the Frequency, Phenotype and Function of Circulating Dendritic Cells in Cattle

Effect of Foot-and-Mouth Disease Virus Infection on the Frequency, Phenotype and Function of Circulating Dendritic Cells in Cattle

The Different Tactics of Foot-and-Mouth Disease Virus to Evade Innate Immunity

Systemic immune response and virus persistence after foot-and-mouth disease virus infection of naïve cattle and cattle vaccinated with a homologous adenovirus-vectored vaccine

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