Changes in Monoamine Oxidase with Aging

Nies, Alexander; Robinson, Donald S.; Davis, John M.; Ravaris, C. Lewis

doi:10.1007/978-1-4684-7770-2_4

Cited by 29 publications

(14 citation statements)

References 28 publications

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“…The finding that female patients tend to have higher platelet MAO activity than men is in line with earlier results (Nies et al, 1974;Murphy et al, 1976). Female patients tended to have more pain as a symptom than men, but the difference in platelet MAO activity found between patients without pain and patients with more severe pain is consistent both within the male and female subgroups (significant, however, only in the female subgroup).…”

Section: Discussionsupporting

confidence: 89%

“…The finding of a weak, significantly positive correlation between platelet MAO activity and age is in line with some earlier findings (Nies et al, 1974) and in disagreement with other (Murphy et al, 1976). Thus, as older patients could be expected to have somewhat higher platelet MAO activity and as the depressed patients with pain were significantly older, the age difference can not explain the finding of lower platelet MAO activity in depressed patients with pain as a symptom.…”

Section: Discussionsupporting

confidence: 81%

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Pain as a symptom in depressive disorders and its relationship to platelet monoamine oxidase activity

Knorring

Perris

Oreland

et al. 1984

J. Neural Transmission

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144 depressed in-patients were rated by means of the Comprehensive Psychopathological Rating Scale (CPRS) and platelet monoamine oxidase (MAO) was determined. 49 per cent of the patients were found to have pain as a symptom, and 21 per cent were found to have more severe pain. The patients with more severe pain were found to have lower platelet MAO activity than the patients without pain or with slight pain. As platelet MAO activity may reflect the turn-over in the serotinergic systems in CNS it is hypothesized that patients with depressive disorders with pain as a symptom may have more pronounced disturbances in the serotinergic systems than patients without pain as a symptom.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 81%

Pain as a symptom in depressive disorders and its relationship to platelet monoamine oxidase activity

Knorring

Perris

Oreland

et al. 1984

J. Neural Transmission

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show abstract

“…It is known that aging is accompanied by a reduction of neurotransmitter function, especially the monoamines (Beck, 1978;Kent, 1976;McGeer & McGeer, 1980;Nies, Robinson, Davis, & Ravaris, 1973) and by the loss of horizontal dendrites, which may have inhibitory properties (Scheibel & Scheibel, 1975). The time increase demonstrated by our older Ss on the interference task could be another behavioral measure of inhibitory difficulty in the elderly; that is, problems with the Stroop interference task may represent deficits in inhibiting input of one stimulus dimension (words) while one is attending to a second stimulus characteristic (color).…”

Section: Discussionmentioning

confidence: 99%

Age-related decrements in stroop color test performance

1984

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Administered a modified Stroop Color‐Word Test to 80 healthy males aged 21‐90 years as part of a study of neuropsychological functioning. No age differences were demonstrated on simple reading tasks; however, significant age effects were observed for the color naming and interference tasks (ps < 001). Ss in the oldest age groups (61‐70 and 71‐90 years) performed more slowly than younger individuals on both of these. Of a variety of tests administered, performance on the Stroop Test was most affected by age. Because impairment on Stroop color naming and interference tests appears to be a concomitant of normal aging, caution should be exercised when one is interpreting Stroop test results from older patients with suspected cerebral dysfunction.

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“…First, as the metabolizing of DA to DOPAC is mediated by monoamine oxidase (MAO), one likely explanation for this accelerated conversion is the increased concentration of MAO and/or enhanced MAO activity. Increased MAO activity has been demonstrated to occur in aged animals (Bhaskaran and Radha, 1983;Fowler et al, 1980;Nies et al, 1973), and it may also occur in the remaining DA neurons after 6-OHDA lesion. Second, under physiological conditions, most of the newly synthesized DA are stored in vesicles to protect them from degradation by MAO, while the majority of DA formed in the lesioned striatum cannot be protected because the storage capacity is diminished by 6-OHDA lesion (Spencer and Wooten, 1984;Brannan et al, 1990).…”

Section: Discussionmentioning

confidence: 96%

L-DOPA modulation of corpus striatal dopamine and dihydroxyphenylacetic acid output from intact and 6-OHDA lesioned rats

Dluzen

1996

J. Neural Transmission

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In the present report we examined the differences in in vitro dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) efflux from the corpus striatum (CS) of intact versus 6-hydroxydopamine (6-OHDA) lesioned (in substantia nigra) male rats in response to different doses of two pulse infusions of L-dihydroxyphenylalanine (L-DOPA). In the first experiment, we tested the effects of two 20-min infusions of 5 uM L-DOPA. In the second experiment we repeated this protocol using 50 uM L-DOPA. There was an overall significantly greater output of DA for intact versus 6-OHDA lesioned rats for both doses. Moreover, in Experiment 1, the 5 uM L-DOPA produced a peak DA response to the second infusion which was significantly higher than that of the first infusion in the intact, but not lesioned rats. In Experiment 2, the 50 uM L-DOPA group showed no significant differences in DA output between the two infusions for both intact and lesioned rats. In contrast to DA responses, there were no overall significant differences in DOPAC output between intact and 6-OHDA lesioned rats for both doses. However, for both doses tested, the peak DOPAC output from the second infusion was significantly increased in lesioned, but not intact rats. These data demonstrate that L-DOPA evoked DA and DOPAC output are differentially modulated in intact and 6-OHDA lesioned striatum. The lesions of the striatal dopaminergic system may alter these responses through changes in intraneuronal storage and metabolism of DA following L-DOPA infusion.

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Changes in Monoamine Oxidase with Aging

Cited by 29 publications

References 28 publications

Pain as a symptom in depressive disorders and its relationship to platelet monoamine oxidase activity

Pain as a symptom in depressive disorders and its relationship to platelet monoamine oxidase activity

Age-related decrements in stroop color test performance

L-DOPA modulation of corpus striatal dopamine and dihydroxyphenylacetic acid output from intact and 6-OHDA lesioned rats

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