Changes in molecular markers of hemostatic and fibrinolytic activation under various sampling conditions using vacuum tube samples from healthy volunteers

Omote, Mika; Asakura, Hitoshi; Takamichi, Sayuri; Shibayama, Masami; Yoshida, Tomotaka; Kadohira, Yasuko; Maekawa, M; Yamazaki, Masahide; Morishita, Eriko; Nakao, Shinji; Wada, Takashi

doi:10.1016/j.thromres.2008.05.008

Cited by 17 publications

(15 citation statements)

References 14 publications

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“…Second limitation is that blood sampling difficulties were not recorded. TAT levels are highly affected by the duration of needle puncturing; the more time it takes to collect blood, the more the TAT levels increase [26]. This artifact can result in a pseudo-positive VTE prediction.…”

Section: Discussionmentioning

confidence: 99%

Venous thromboembolism in hospitalized patients receiving chemotherapy for malignancies at Japanese community hospital: prospective observational study

et al. 2017

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BackgroundAlthough Asian population was recognized to have a lower risk of venous thromboembolism (VTE), its increasing prevalence and incidence remain unclear in patients with malignancies. We attempted to predict VTE development using activation markers of coagulation and fibrinolysis.MethodsWe enrolled patients with malignancy admitted to Tonan Hospital between April and December 2014 to receive a new-for-them chemotherapy regimen. All patients were examined for VTE by computed tomography and whole-leg compression ultrasonography before chemotherapy and three months later. We also examined plasma levels of thrombin-antithrombin complex (TAT) and plasmin α2-plasmin inhibitor complex (PIC) before chemotherapy. The cut off values of TAT and PIC were set at 2.1 ng/mL and 1.8 μg/mL, respectively.ResultsOf 97 patients, the majority (67%) had distant metastases. The most common malignancies were colorectal (26%), breast (23%), and stomach (19%) cancer. VTE was detected in 29 patients (31%); all were asymptomatic. VTE was newly developed in 12 patients in the three-month observation period, which means the incidence was 49 per 1000 person-years. Non-increased PIC with increased TAT was the only significant risk factor for both VTE prevalence and incidence in multivariate analysis, and the odds ratios were 3.0 (95% confidence interval, 1.1–8.2; P = 0.034) and 9.4 (95% confidence interval, 1.7–51.9; P = 0.011), respectively.ConclusionsThe prevalence and incidence of VTE were high in hospitalized Japanese patients receiving chemotherapy for malignancies. Non-increased PIC with increased levels of TAT may be an independent risk factor for VTE development.

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Section: Discussionmentioning

confidence: 99%

Venous thromboembolism in hospitalized patients receiving chemotherapy for malignancies at Japanese community hospital: prospective observational study

et al. 2017

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“…It has been shown that various conditions of blood sampling affect plasma levels of F1 1 2 but not D-dimer. 35 Throughout the observation period, absolute values for D-dimer remained within the reference range despite increasing significantly. Prö bstle and col-leagues also reported a D-dimer increase within normal limits during laser ablation.…”

Section: Discussionmentioning

confidence: 86%

Does Endovenous Laser Ablation Induce Endothelial Damage at the Saphenofemoral Junction?

Heere-Ress

Veensalu²,

Wacheck³

et al. 2011

Dermatologic Surgery

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“…Thrombin–antithrombin concentration is a very sensitive coagulation marker. An artificial increase of more than 10 times in TAT concentrations was reported in samples in people when TAT concentrations were measured using an inadequate sampling method . In the present study, samples were collected through the jugular vein using a 23‐Ga needle.…”

Section: Discussionmentioning

confidence: 89%

Evaluation of an automated point‐of‐care test system for measuring thrombin–antithrombin complex in dogs

Kato

Takahashi

Yonezawa

et al. 2019

J Vet Emergen Crit Care

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Objective:To evaluate the utility of the chemiluminescent enzyme immunoassay (CLEIA) method for point-of-care (POC) measurement of canine plasma thrombin-antithrombin complex (TAT) concentration. Assessment and Main Results:Plasma TAT concentration was measured in 54 healthy dogs and in 72 dogs with various diseases. A significant correlation was found between TAT concentration measured by CLEIA and that measured by an ELISA that was previously used in dogs. The upper limit of the reference value of TAT concentrations measured by CLEIA was determined to be 0.2 ng/mL based on the TAT concentration in 54 healthy dogs. TAT concentrations exceeded the reference interval in a portion of dogs when a hypercoagulable state may be present. Conclusions:Canine plasma TAT concentrations measured using CLEIA were correlated with that measured using ELISA. Hence, a POC testing instrument may be used for early detection of activation of thrombin generation in emergency and critical care settings.

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Changes in molecular markers of hemostatic and fibrinolytic activation under various sampling conditions using vacuum tube samples from healthy volunteers

Cited by 17 publications

References 14 publications

Venous thromboembolism in hospitalized patients receiving chemotherapy for malignancies at Japanese community hospital: prospective observational study

Venous thromboembolism in hospitalized patients receiving chemotherapy for malignancies at Japanese community hospital: prospective observational study

Does Endovenous Laser Ablation Induce Endothelial Damage at the Saphenofemoral Junction?

Evaluation of an automated point‐of‐care test system for measuring thrombin–antithrombin complex in dogs

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