Changes in mitochondrial distribution occur at the axon initial segment in association with neurodegeneration inDrosophila
Andrew P. K. Wodrich,
Brent T. Harris,
Edward Giniger
Abstract:Changes in mitochondrial distribution are a feature of numerous age-related neurodegenerative diseases. In Drosophila, reducing the activity of Cdk5 causes a neurodegenerative phenotype and is known to affect several mitochondrial properties. Therefore, we investigated whether alterations of mitochondrial distribution are involved in Cdk5-associated neurodegeneration. We find that reducing Cdk5 activity does not alter the balance of mitochondrial localization to the somatodendritic vs. axonal neuronal compartm… Show more
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