Changes in microglia chromatin accessibility in aged female mice
Victor A. Ansere,
Kyla B. Tooley,
Kottapalli Srividya
et al.
Abstract:Aged female microglia display a more inflammatory and disease-associated phenotype compared to age-matched males. Epigenetic mechanisms, such as chromatin accessibility, are key drivers of microglial plasticity and phenotypes necessary for development, priming, and immune activation. Therefore, alterations in chromatin accessibility patterns can potentially regulate the neuroimmune responses and phenotypes observed in female microglia with aging, but to date have not been assessed. In this study, hippocampal m… Show more
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