Changes in microbial ecology and use of cloxacillin

Loulergue, J.; Audurier, A; Delarbre, J.-M.; Gialluly, C. de

doi:10.1016/0195-6701(94)90115-5

Cited by 18 publications

(8 citation statements)

References 16 publications

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“…Despite our use of this analysis, we could not directly determine a hierarchy among the different antimicrobial classes. The importance of b-lactams and fluoroquinolones that we observed is consistent with the findings of Loulergues et al [22], who compared data for different surgical units in a hospital, and those of Crowcroft et al [16] and Monnet et al [25], who performed interhospital comparisons. Crowcroft et al [16] and Monnet et al [25] observed a positive correlation between the frequency of resistance among Staphylococcus aureus isolates among the species and antimicrobial use; in the study of Monnet et al [25] (ICARE project), the correlation was with use of carboxy-or ureido-penicillins, and, in the study of Crowcroft et al [16] (which was performed in Belgian hospitals), the correlation was with use of ceftazidime, cefsulodin, amoxicillin plus clavulanic acid, and quinolones.…”

Section: Discussionsupporting

confidence: 92%

Relationship between Spread of Methicillin‐ResistantStaphylococcus aureusand Antimicrobial Use in a French University Hospital

et al. 2003

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The objective of our study was to determine whether antibiotic pressure in the units of a teaching hospital affects the acquisition of methicillin-resistant Staphylococcus aureus (MRSA), independently of the other collective risk factors previously shown to be involved (MRSA colonization pressure, type of hospitalization unit, and care workload). The average incidence of acquisition of MRSA during the 1-year study period was 0.31 cases per 1000 days of hospitalization, and the use of ineffective antimicrobials reached 504.54 daily defined doses (DDDs) per 1000 days of hospitalization. Univariate analysis showed that acquisition of MRSA was significantly correlated with the use of all antimicrobials, as well as correlated with the use of each class of antimicrobial and with colonization pressure. Multivariate analysis with a Poisson regression model showed that the use of antimicrobials was associated with the incidence of acquisition of MRSA, independently of the other variables studied, but it did not allow us to determine the hierarchy of the different antimicrobial classes with respect to the effect.

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Section: Discussionsupporting

confidence: 92%

Relationship between Spread of Methicillin‐ResistantStaphylococcus aureusand Antimicrobial Use in a French University Hospital

et al. 2003

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“…In contrast, the results of Wibbenmeyer et al [24], revealed an independent association of younger age and prior treatment with vancomycin with MRSA acquisition. As mentioned above, we were not able to evaluate the exposure of patients to different antibiotic regimens, However, the impact of specific antibiotic regimens and the incidence of MRSA are very unclear [6] and various authors have reported that different antibiotics select for MRSA infections [23,[39][40][41][42] These somewhat conflicting reports warrant future investigations aiming to clarify this association.…”

Section: Discussionmentioning

confidence: 80%

Risk factors for, and the effect of MRSA colonization on the clinical outcomes of severely burnt patients

Issler‐Fisher

McKew

Fisher

et al. 2015

Burns

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“…We can hypothesize that the frequent use of invasive devices, the antibiotic pressure and the extremely poor general condition of intensive care patients are some factors favouring the emergence of resistant staphylococcal infections. It is difficult to correlate our data with the general incidence of MRSA in ICU, because few recent data are available, with analysis often limited to bacteraemia or results not specific to ICU [22,23]. The frequency of MRSA is higher in ICU than in general wards [11,24,37] unless special measures are applied (H. Lessire et al, abstract, 4th International Conference on the Prevention of Infection, Nice, 1996).…”

Section: Discussionmentioning

confidence: 93%

Epidemiology of infections in the adult medical intensive care unit of a cancer hospital

Berghmans

Crokaert

Markiewicz

et al. 1997

Supportive Care in Cancer

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A prospective collection of positive antimicrobial cultures was performed over 12 consecutive months in the medical intensive care unit of a cancer hospital. In all, 144 infections and 163 pathogens were documented during 87 of the 528 admissions. Lung, urinary, ENT (ear, nose and throat) infections and bacteraemia were the most frequently documented. Staphylococcus species, Streptococcus species, Escherichia coli, Klebsiella species and Pseudomonas species were the most common pathogens. Gram-positive strains were observed predominantly during monomicrobial bacteraemia (48.9%). Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE) were found in 58% and 92% of the isolated strains respectively. No particular outbreak was identified. A further prospective study will be necessary to evaluate the impact of the antibiotic use on the selection of resistant strains in our ICU.

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Changes in microbial ecology and use of cloxacillin

Cited by 18 publications

References 16 publications

Relationship between Spread of Methicillin‐ResistantStaphylococcus aureusand Antimicrobial Use in a French University Hospital

Relationship between Spread of Methicillin‐ResistantStaphylococcus aureusand Antimicrobial Use in a French University Hospital

Risk factors for, and the effect of MRSA colonization on the clinical outcomes of severely burnt patients

Epidemiology of infections in the adult medical intensive care unit of a cancer hospital

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