Changes in micro-CT 3D bone parameters reflect effects of a potent cathepsin K inhibitor (SB-553484) on bone resorption and cortical bone formation in ovariectomized mice

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys

“…In rhesus monkeys treated for 21 months with odanacatib, femur neck periosteal bone formation showed a dose-dependent increasing trend [27]; in addition, periosteal MAR was significantly increased and BFR tended to be increased in mid-femur [28]. In mice, evidence of a stimulatory effect of the cathepsin K inhibitor SB-553484 on cortical bone formation was reported [29]. However, the present report appears to be the first to find stimulation of periosteal bone formation at multiple sites.…”

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys

“…In rhesus monkeys treated for 21 months with odanacatib, femur neck periosteal bone formation showed a dosedependent increasing trend [27]; in addition periosteal MAR was significantly increased and BFR tended to be increased in mid-femur [28]. In mice, evidence of a stimulatory effect of the cathepsin K inhibitor SB-553484 on cortical bone formation was reported [29]. However, the present report appears to be the first to find stimulation of periosteal bone formation at multiple sites.…”

Relationship between architectural parameters and sample volume of human cancellous bone in micro-CT scanning

“…Bagi and co-worker [21] proposed an alternative method with in vitro micro-CT for the two-(2D) and three-dimensional (3D) analyses of bone tissues using mice as the subject with an image resolution of 12 m and the volume of sample was a 1-mm cube. Another study [22] with mice as the subject was carried out to investigate the structure change of cancellous bone caused by the cathepsin K inhibitor, and the volume of sample was a 1.5-mm cube. In some other studies, the volume of interest is not a primitive shape.…”