Changes in Metabolic Parameters in Cows in the Study of Subchronic Toxicity Of Aminoseleferon-B

Abstract

The study of subchronic toxicity of aminoseleferon-B was performed on lactating cows, which were administered the drug at a therapeutic dose (10 ml) for 7 days with an interval of 24 hours. The toxic effect of the drug was assessed by the clinical state of animals, morphological and biochemical blood indicators. Changes in the hematological and biochemical status of cows after administration of aminoseleferon-B were characterized by an increase of blood concentration of hemoglobin, leukocytes and lymphocytes, total protein, gamma-globulins, glucose, the activity of alkaline phosphatase, and a decrease in the level of total lipids that was a consequence of the pharmacological action of the biologically active components of the drug. As a result of the conducted studies, there was detected no negative effect of aminoseleferon-B on the body of clinically healthy cows when studying subchronic toxicity.