Changes in metabolic indices in response to whole blood donation in male subjects with normal glucose tolerance

Borai, Anwar; Livingstone, Callum; Anwar, Firoz; Baljoon, Dalal; sofyani, Abeer Al; Bahijri, Suhad; Kadam, I; Hafiz, Khalid; Abdelaal, M.

doi:10.1016/j.clinbiochem.2015.08.023

Cited by 12 publications

(17 citation statements)

References 25 publications

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“…More recently, a large group (n = 42) of non-diabetic blood donors, who didn’t donate blood for at least 6 months, showed no significant reduction in HbA 1c after whole blood donation. However, the time points used for HbA 1c measurement were few and mostly short after whole blood donation (500 mL; 24 hours, 1 week, 2 weeks, 3 months) [4]. One study assessed the effect of blood-letting on HbA 1c in patients with type 2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…As glycation of hemoglobin is a relatively slow chemical process [2], the increased synthesis of erythrocytes will therefore, theoretically, result in a drop in HbA 1c for a number of weeks. Previous research has indeed suggested that blood loss and/or whole blood donation can affect HbA 1c formation [3,4]. However, the precise effect of whole blood donation on HbA 1c dynamics has not been thoroughly studied and blood donors diagnosed with type 2 diabetes haven’t been included in previous research.…”

Section: Introductionmentioning

confidence: 99%

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Whole Blood Donation Affects the Interpretation of Hemoglobin A1c

et al. 2017

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IntroductionSeveral factors, including changed dynamics of erythrocyte formation and degradation, can influence the degree of hemoglobin A1c (HbA1c) formation thereby affecting its use in monitoring diabetes. This study determines the influence of whole blood donation on HbA1c in both non-diabetic blood donors and blood donors with type 2 diabetes.MethodsIn this observational study, 23 non-diabetic blood donors and 21 blood donors with type 2 diabetes donated 475 mL whole blood and were followed prospectively for nine weeks. Each week blood samples were collected and analyzed for changes in HbA1c using three secondary reference measurement procedures.ResultsTwelve non-diabetic blood donors (52.2%) and 10 (58.8%) blood donors with type 2 diabetes had a significant reduction in HbA1c following blood donation (reduction >-4.28%, P < 0.05). All non-diabetic blood donors with a normal ferritin concentration predonation had a significant reduction in HbA1c. In the non-diabetic group the maximum reduction was -11.9%, in the type 2 diabetes group -12.0%. When eligible to donate again, 52.2% of the non-diabetic blood donors and 41.2% of the blood donors with type 2 diabetes had HbA1c concentrations significantly lower compared to their predonation concentration (reduction >-4.28%, P < 0.05).ConclusionPatients with type 2 diabetes contributing to whole blood donation programs can be at risk of falsely lowered HbA1c. This could lead to a wrong interpretation of their glycemic control by their general practitioner or internist.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Whole Blood Donation Affects the Interpretation of Hemoglobin A1c

et al. 2017

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“…Repeated phlebotomies of patients with type 2 diabetes significantly decreased serum glucose levels [144]. Blood donation or phlebotomy was associated with more favorable or improved metabolic indices associated with diabetes risk in subjects without diagnosed diabetes [144, 157–160]. In another study, blood donations did not influence diabetes risk [161].…”

Section: Management Of Diabetes In Hfe Hemochromatosismentioning

confidence: 99%

Diabetes inHFEHemochromatosis

Barton

Acton

2017

Journal of Diabetes Research

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Diabetes in whites of European descent with hemochromatosis was first attributed to pancreatic siderosis. Later observations revealed that the pathogenesis of diabetes in HFE hemochromatosis is multifactorial and its clinical manifestations are heterogeneous. Increased type 2 diabetes risk in HFE hemochromatosis is associated with one or more factors, including abnormal iron homeostasis and iron overload, decreased insulin secretion, cirrhosis, diabetes in first-degree relatives, increased body mass index, insulin resistance, and metabolic syndrome. In p.C282Y homozygotes, serum ferritin, usually elevated at hemochromatosis diagnosis, largely reflects body iron stores but not diabetes risk. In persons with diabetes type 2 without hemochromatosis diagnoses, serum ferritin levels are higher than those of persons without diabetes, but most values are within the reference range. Phlebotomy therapy to achieve iron depletion does not improve diabetes control in all persons with HFE hemochromatosis. The prevalence of type 2 diabetes diagnosed today in whites of European descent with and without HFE hemochromatosis is similar. Routine iron phenotyping or HFE genotyping of patients with type 2 diabetes is not recommended. Herein, we review diabetes in HFE hemochromatosis and the role of iron in diabetes pathogenesis in whites of European descent with and without HFE hemochromatosis.

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“… 2 , 5 , 6 , 7 Nevertheless, our knowledge about the relationship between body iron stores and glucose homeostasis is mostly derived from epidemiological surveys 8 , 9 or interventional studies aiming at lowering iron stores towards target levels. 10 , 11 , 12 , 13 , 14 , 15 The latter was achieved through phlebotomies and led to conflicting results, some reports showing an improvement in glucose homeostasis in patients with HH, 11 T2D, 12 glucose intolerance, 14 metabolic syndrome (MetS) 15 or in healthy blood donors, 10 , 13 while others showed no improvement in patients with HH 16 or MetS. 17 Besides, several systematic reviews with or without meta-analysis showed no conclusive evidence for significant improvement of metabolic parameters after phlebotomy.…”

Section: Introductionmentioning

confidence: 99%