Changes in metabolic and physiological biomarkers in Mangalarga Marchador horses with induced obesity

Ribeiro, Rodrigo Martins; Ribeiro, Débora Stremel; Cota, Leticia O.; Leme, Fabíola Oliveira Paes; Carvalho, Armando Mattos; Faleiros, Rafael Resende

doi:10.1016/j.tvjl.2021.105627

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…However, our observation is in line with the study conducted by Ribeiro et al, in which Mangalarga Marchador horses fed on a hypercaloric diet experienced a significant increase in cholesterol after 30 days, and this increase was maintained for 150 days. Interestingly, NEFA values did not differ from the baseline [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Clustering and Correlations amongst NEFA, Selected Adipokines and Morphological Traits—New Insights into Equine Metabolic Syndrome

Daradics

Niculae

Crecan

et al. 2022

Animals

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Obesity is a common feature in horses suffering from metabolic syndrome. While adipokines involvement as biomarkers is better established in human pathology, little data are available on horses. This study aimed to investigate the possible association and relationship between selected metabolic parameters and morphological traits in equine metabolic syndrome. Adiposity was evaluated using body condition score (BCS) and cresty neck score (CNS). Plasma levels of total cholesterol, insulin, NEFA, and adipokines (omentin and chemerin) were determined using enzyme-linked immunosorbent assays. Spearman correlation, univariate linear regression analysis and hierarchical clustering were performed. Significant positive correlations were observed between NEFA and bodyweight (r = 0.322; p = 0.006), BCS (r = 0.295; p = 0.013), and CNS (r = 0.267; p = 0.024), total cholesterol and bodyweight (r = 0.262; p = 0.027), and omentin and CNS (r = 0.234; p = 0.049). Cluster analysis supported these results and provided more details on the relationships between studied variables within and between the four resulting groups. These findings highlight NEFA, chemerin, and omentin as valuable biomarkers that could be further analyzed in other horse breeds for a better understanding of equine metabolic pathology.

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Section: Discussionmentioning

confidence: 99%

Clustering and Correlations amongst NEFA, Selected Adipokines and Morphological Traits—New Insights into Equine Metabolic Syndrome

Daradics

Niculae

Crecan

et al. 2022

Animals

View full text Add to dashboard Cite

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Metabolic Profile Changes in Mangalarga Marchador Horses Subjected to A Hypercaloric Diet Evaluated by Proton NMR Spectroscopy

Duarte

Ribeiro²,

Machado

et al. 2021

Journal of Equine Veterinary Science

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Follicular metabolic alterations are associated with obesity in mares and can be mitigated by dietary supplementation

Catandi,

Fresa,

Cheng

et al. 2024

Sci Rep

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Obesity is a growing concern in human and equine populations, predisposing to metabolic pathologies and reproductive disturbances. Cellular lipid accumulation and mitochondrial dysfunction play an important role in the pathologic consequences of obesity, which may be mitigated by dietary interventions targeting these processes. We hypothesized that obesity in the mare promotes follicular lipid accumulation and altered mitochondrial function of oocytes and granulosa cells, potentially contributing to impaired fertility in this population. We also predicted that these effects could be mitigated by dietary supplementation with a combination of targeted nutrients to improve follicular cell metabolism. Twenty mares were grouped as: Normal Weight [NW, n = 6, body condition score (BCS) 5.7 ± 0.3], Obese (OB, n = 7, BCS 7.7 ± 0.2), and Obese Diet Supplemented (OBD, n = 7, BCS 7.7 ± 0.2), and fed specific feed regimens for ≥ 6 weeks before sampling. Granulosa cells, follicular fluid, and cumulus-oocyte complexes were collected from follicles ≥ 35 mm during estrus and after induction of maturation. Obesity promoted several mitochondrial metabolic disturbances in granulosa cells, reduced L-carnitine availability in the follicle, promoted lipid accumulation in cumulus cells and oocytes, and increased basal oocyte metabolism. Diet supplementation of a complex nutrient mixture mitigated most of the metabolic changes in the follicles of obese mares, resulting in parameters similar to NW mares. In conclusion, obesity disturbs the equine ovarian follicle by promoting lipid accumulation and altering mitochondrial function. These effects may be partially mitigated with targeted nutritional intervention, thereby potentially improving fertility outcomes in the obese female.

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Changes in metabolic and physiological biomarkers in Mangalarga Marchador horses with induced obesity

Cited by 5 publications

References 14 publications

Clustering and Correlations amongst NEFA, Selected Adipokines and Morphological Traits—New Insights into Equine Metabolic Syndrome

Clustering and Correlations amongst NEFA, Selected Adipokines and Morphological Traits—New Insights into Equine Metabolic Syndrome

Metabolic Profile Changes in Mangalarga Marchador Horses Subjected to A Hypercaloric Diet Evaluated by Proton NMR Spectroscopy

Follicular metabolic alterations are associated with obesity in mares and can be mitigated by dietary supplementation

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