Changes in memory performance over a 12-month period in relation to achieving symptomatic remission after a first-episode psychosis

Benoit, Audrey; Bodnar, Michael; Malla, Ashok; Joober, Ridha; Bherer, Louis; Lepage, Martín

doi:10.1016/j.schres.2014.01.024

Cited by 16 publications

(17 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results also have showed that nonremitted first-episode schizophrenia patients performed worse in verbal memory domain and there is a positive correlation between bilateral parahippocampal cortex volume and verbal memory performance. These results are in line with Chang et al [14], and Benoit et al [15], but are not confirmed by Torgalsbøen et al [13]. Notwithstanding, Torgalsbøen et al [13] is an outgoing study, and is recommended to wait for the results from the next follow-up before drawing conclusions.…”

Section: First-episode Psychosis/schizophreniasupporting

confidence: 49%

“…However, despite verbal memory performance are strongly related to clinical remission in first episode of schizophrenia spectrum [14,15], it appears to have not a meaningful contribution to functional recovery [16]. However, these results differ from some published studies that suggest that verbal memory deficits might reduce one's employment prospects compromising overall functional outcome [24,25].…”

Section: Acta Psychopathologica Issn 2469-6676mentioning

confidence: 72%

“…They conclude that verbal memory contributed only slightly to such outcome, while length of remission of negative and positive symptoms made a large contribution at 2 years. These results highlights that despite verbal memory performance is strongly related to clinical remission in first episode of schizophrenia spectrum [14,15], it appears to have not a meaningful contribution to functional recovery.…”

Section: First-episode Psychosis/schizophreniamentioning

confidence: 79%

“…Hospitalized EOS subjects (aged [13][14][15][16][17][18] with first episode at the introduction of pharmacotherapy (FES T1) and after the resolution of psychotic symptoms at psychopathological symptoms mean 7 weeks (FES T2) and Stable Outpatients (SO) group (aged 16-19 with diagnosis of early-onset schizophrenia, with at least one previous hospitalization and illness duration of minimum one year) were matched with healthy controls. Severity of symptoms was assessed with Positive and Negative Syndrome Scale (PANSS), total score and positive, negative and general psychopathology subscales scores were analyzed, however any formalized definition of remission was applied.…”

Section: Early-onset Schizophrenia (Eos)mentioning

confidence: 99%

“…Based on previous investigations on FEP that have isolated verbal memory as a potential cognitive marker of symptomatic remission, Benoit et al [15], designed a study aimed to compare verbal, visual and working memory performance between remitted and non-remitted FEP longitudinally. Using the full RSWG criteria to categorized symptomatic remission, cognition was evaluated after 3 and 15 months of treatment.…”

Section: First-episode Psychosis/schizophreniamentioning

confidence: 99%

See 4 more Smart Citations

From “What” to “How”: The Effort to Fill the Gaps in Understanding Cognitive Processes Underpinning Remission in Schizophrenia

Rabanea-Souza¹

2016

Acta Psychopathol

View full text Add to dashboard Cite

Introduction: The accumulation of robust evidence culminated in the establishment of the cognitive deficits as a core symptom of Schizophrenia (SCZ). To date, there has been reliable evidence that cognitive deficits are associated with poor symptomatic outcomes in SCZ. Nevertheless, they have not been incorporated in definitions of remission and a systematic understanding of how cognition contributes to remission is still lacking. Although the standardized remission in SCZ criteria proposed in 2005 has encouraged studies to understand the role of cognitive function in symptomatic remission from SCZ, most investigations were cross-sectional and have studied samples of chronically ill patients. The purpose of the present study was to bring together the efforts of recent follow-up studies in early in earlier stages of the disease to fill the gap in the literature on understanding how cognitive impairment is related to remission.

show abstract

Section: First-episode Psychosis/schizophreniasupporting

confidence: 49%

Section: Acta Psychopathologica Issn 2469-6676mentioning

confidence: 72%

Section: First-episode Psychosis/schizophreniamentioning

confidence: 79%

Section: Early-onset Schizophrenia (Eos)mentioning

confidence: 99%

Section: First-episode Psychosis/schizophreniamentioning

confidence: 99%

See 3 more Smart Citations

From “What” to “How”: The Effort to Fill the Gaps in Understanding Cognitive Processes Underpinning Remission in Schizophrenia

Rabanea-Souza¹

2016

Acta Psychopathol

View full text Add to dashboard Cite

show abstract

Verbal memory impairments in schizophrenia associated with cortical thinning

Guimond

Chakravarty

Bergeron-Gagnon

et al. 2016

NeuroImage: Clinical

View full text Add to dashboard Cite

Verbal memory (VM) represents one of the most affected cognitive domains in schizophrenia. Multiple studies have shown that schizophrenia is associated with cortical abnormalities, but it remains unclear whether these are related to VM impairments. Considering the vast literature demonstrating the role of the frontal cortex, the parahippocampal cortex, and the hippocampus in VM, we examined the cortical thickness/volume of these regions. We used a categorical approach whereby 27 schizophrenia patients with ‘moderate to severe’ VM impairments were compared to 23 patients with ‘low to mild’ VM impairments and 23 healthy controls. A series of between-group vertex-wise GLM on cortical thickness were performed for specific regions of interest defining the parahippocampal gyrus and the frontal cortex. When compared to healthy controls, patients with ‘moderate to severe’ VM impairments revealed significantly thinner cortex in the left frontal lobe, and the parahippocampal gyri. When compared to patients with ‘low to mild’ VM impairments, patients with ‘moderate to severe’ VM impairments showed a trend of thinner cortex in similar regions. Virtually no differences were observed in the frontal area of patients with ‘low to mild’ VM impairments relative to controls. No significant group differences were observed in the hippocampus. Our results indicate that patients with greater VM impairments demonstrate significant cortical thinning in regions known to be important in VM performance. Treating VM deficits in schizophrenia could have a positive effect on the brain; thus, subgroups of patients with more severe VM deficits should be a prioritized target in the development of new cognitive treatments.

show abstract

Early clinical recovery in first-episode psychosis: Symptomatic remission and its correlates at 1-year follow-up

Simonsen

Færden

Romm

et al. 2017

Psychiatry Research

View full text Add to dashboard Cite

Changes in memory performance over a 12-month period in relation to achieving symptomatic remission after a first-episode psychosis

Cited by 16 publications

References 35 publications

From “What” to “How”: The Effort to Fill the Gaps in Understanding Cognitive Processes Underpinning Remission in Schizophrenia

From “What” to “How”: The Effort to Fill the Gaps in Understanding Cognitive Processes Underpinning Remission in Schizophrenia

Verbal memory impairments in schizophrenia associated with cortical thinning

Early clinical recovery in first-episode psychosis: Symptomatic remission and its correlates at 1-year follow-up

Contact Info

Product

Resources

About