Changes in Mcl-1 expression in rectal cancer in relation to neo-adjuvant radiotherapy

Abstract

Our findings indicate that irradiated rectal cancer produces significantly higher levels of the antiapoptotic protein Mcl-1 than non-irradiated rectal carcinoma. The data also suggest that the high level of Mcl-1 was induced by the radiotherapy. As Mcl-1 is an antiapoptotic regulator, its over-expression in irradiated rectal cancer could constitute a detrimental development antagonizing the potential benefit of adjuvant radiotherapy. Further evaluation of the correlation between Mcl-1 expression and overall survival seems warranted.

Serine 162, an Essential Residue for the Mitochondrial Localization, Stability and Anti-Apoptotic Function of Mcl-1

“…For example, Mcl-1 plays a key role in development, control of the cell cycle and resistance to apoptosis [5], [6] whereas defects in its expression underlie a number of pathologies, such as impaired development/maintenance of B- and T-lymphocytes [7] and enhanced apoptosis of differentiating monocytic U-937 [8]. Over-expression of Mcl-1 underpins malignancies that include multiple myeloma [9], hepatocellular carcinomas [10], colon carcinomas [11] and chronic myeloid leukaemia [12].…”

Expression of Mcl-1 and Ki-67 in Papillary Thyroid Carcinomas

“…Over the last two decades, there have been limited data related to Mcl-1 protein expression in different thyroid tissues and the impact of the expression levels on the clinical prognosis in PTC [18,22]. However, Mcl-1 expression has been shown to be a poor prognostic marker in other solid tumors, such as breast, cervical, colon, ovarian, and gastric cancers [20,[23][24][25][26]. Moreover, there is evidence of the involvement of Mcl-1 protein and its association with Ki-67 expression resulting in poor prognosis, as demonstrated in cervical cancer [23].…”