Changes in maternal secretory immunoglobulin a levels in human milk during 12 weeks after parturition

Abstract

The SIgA levels gradually decreased up to week 12. However, the concentration of SIgA in breast milk did not change constantly. It changed relatively rapid until 4 weeks after childbirth, and because the concentration from the third day to the eighth week became 50%, it was understood that the change was temporal.

Immunoglobulin A and nutrients in milk from great apes throughout lactation

“…Orangutan and gorilla milk contain a lower concentration of sIgA compared with human milk. The concentration of sIgA across gorillas and orangutans, for the first 36 MPP, was 29.5 mg/L which is about 20–30 times lower than the concentrations of sIgA in human mature milk (Goldman et al, ; Kawano and Emori, ; Miller and McConnell, ).…”

“…Despite its potential importance, studies evaluating sIgA concentration in non‐human apes are lacking, whereas data regarding sIgA concentration is available for humans from a wide range of populations (Breakey et al, ; Goldman, Garza, Nichols, & Goldblum, ; Hennart, Brasseur, Delogne‐Desnoeck, Dramaix, & Robyn, ; Kawano and Emori, ; Miller and McConnell, ; Olivares et al, ; Smilowitz et al, ; Weaver, Arthur, Bunn, & Thomas, ). In a study of Japanese women, milk sIgA was greater than 2,000 mg/L within a few days of parturition, declining to about 1,000 mg/L by 8–12 wk postpartum (Kawano and Emori, ). Mean milk sIgA values ranged from 308 to 855 mg/L in the study of Toba women (Breakey et al, ).…”

The Role of Maternal Breast Milk in Preventing Infantile Diarrhea in the Developing World

“…Colostrum, the first breast milk fluid produced in the first five days postpartum, is rich in proteins, such as lactoferrin, immunoglobulins and development factors; its main function is to protect the newborn from infections and promote gut maturation [21••]. One study found the highest immunoglobulin A concentration in the third day after delivery [58]. Transitional milk produced from the sixth day to the second week postpartum is an intermediate fluid with some protective and nutritional properties.…”

“…In contrast, mature milk (after the fourth week postpartum) has a higher concentration of lipids and lactose, and lower concentration of proteins [21••]. Beyond week 12, the immunoglobulin levels decreased gradually [58]. …”

Passive acquisition of anti-Staphylococcus aureus antibodies by newborns via transplacental transfer and breastfeeding, regardless of maternal colonization

“…Kawano and Emori 36 assessed total secretory IgA in human milk and found higher IgA concentrations in the colostrum samples at 72 hours post-partum in primiparous women. In the present study, there were more primiparous women in the control group, but we found higher total IgA concentrations in the case group.…”