Changes in Maternal Platelet Physiology during Gestation and Their Interaction with Trophoblasts

Forstner, Désirée; Guettler, Jacqueline; Gauster, Martin

doi:10.3390/ijms221910732

Cited by 18 publications

(10 citation statements)

References 124 publications

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“…Platelet count had a significant but negative correlation with the duration of hypertension illness, while MPV showed a positive and significant correlation [ 49 ]. Increased platelet activation, and the subsequent occurrence of placental fibrinoid deposition, are linked to placenta pathologies such as preeclampsia [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

Figueroa-Mujica

Ccahuantico

Ccorahua-Ríos

et al. 2022

Life

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The objectives of the study were to determine differences in the parameters of red blood cells (RBC), white blood cells (WBC), and platelets at low altitude (LA) and at high altitude (HA) and with the gestation being advanced, and to determine correlations between parameters of RBC and platelets. We also studied the association of RBC and platelets with markers of iron status. In addition, markers of iron status and inflammation were measured and compared at each trimester of gestation in pregnant women at LA and HA. A cross-sectional comparative study was conducted at Lima (150 m above sea level) and Cusco at 3400 m above sea level from May to December 2019. Hematological parameters in pregnant women (233 at LA and 211 at HA) were analyzed using an automated hematology analyzer. Serum ferritin levels, soluble transferrin receptor (sTfR), hepcidin, erythropoietin, testosterone, estradiol, and interleukin-6 (IL6) levels were measured by ELISA. One-way ANOVA supplemented with post hoc test, chi-square test, and Pearson correlation test statistical analyses were performed. p < 0.05 was considered significant. Pregnant woman at HA compared to LA had significantly lower WBC (p < 0.01), associated with higher parameters of the RBC, except for the mean corpuscular volume (MCV) that was no different (p > 0.05). Platelets and mean platelet volume (MPV) were higher (p < 0.01), and platelet distribution width (PDW) was lower at HA than at LA (p < 0.01). A higher value of serum ferritin (p < 0.01), testosterone (p < 0.05), and hepcidin (p < 0.01) was observed at HA, while the concentration of sTfR was lower at HA than at LA (p < 0.01). At LA, neutrophils increased in the third trimester (p < 0.05). RBC parameters decreased with the progress of the gestation, except RDW-CV, which increased. The platelet count decreased and the MPV and PDW were significantly higher in the third trimester. Serum ferritin, hepcidin, and serum testosterone decreased, while sTfR and serum estradiol increased during gestation. At HA, the WBC and red blood cell distribution width- coefficient of variation (RDW-CV), PCT, and serum IL-6 did not change with gestational trimesters. RBC, hemoglobin (Hb), hematocrit (Hct), mean corpuscular hemoglobin concentration (MCHC), and platelet count were lower as gestation advanced. MCV, MPV, and PDW increased in the third trimester. Serum ferritin, testosterone, and hepcidin were lower in the third trimester. Serum estradiol, erythropoietin, and sTfR increased as gestation progressed. Direct or inverse correlations were observed between RBC and platelet parameters and LA and HA. A better number of significant correlations were observed at HA. Hb, Hct, and RDW-CV showed a significant correlation with serum ferritin at LA and HA. Of these parameters, RDW-CV and PDW showed an inversely significant association with ferritin (p < 0.05). In conclusion, a different pattern was observed in hematological markers as well as in iron status markers between pregnant women at LA and HA. In pregnant women a significant correlation between several RBC parameters with platelet marker parameters was also observed. Data suggest that pregnant women at HA have adequate iron status during pregnancy as reflected by higher serum ferritin levels, lower sTfR levels, and higher hepcidin values than pregnant women at LA.

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Section: Discussionmentioning

confidence: 99%

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

Figueroa-Mujica

Ccahuantico

Ccorahua-Ríos

et al. 2022

Life

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“…The second is about the development of immunotherapies. It is well known that excessive inflammatory response is a key driver of preeclampsia, and alterations in the number and activity of immune cells may prevent or inhibit the development of the disease, for example, researchers have now proposed CAR T-cell therapy to ameliorate the development of preeclampsia from theory ( 76 ), however, for the exact corellation between impaired immune cells and preeclampsia, the underlying mechanism, the validation of preclinical rodent models, and the feasibility of immunotherapies still need to be further explored and validated. Finally, we still need to explore markers with high sensitivity and specificity and the exact mechanism, which are important for the future exploration of the optimal timing of intervention, prevention and development of therapeutic approaches for HDP.…”

Section: Discussionmentioning

confidence: 99%

Global trends in research of immune cells associated with hypertensive disorders of pregnancy: A 20-year bibliometric analyses (from 2001 to 2021)

Wang

Tong

2023

Front. Immunol.

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BackgroundA growing evidence suggests that immune cells play a significant role in the pathogenesis of hypertensive disorders of pregnancy (HDP).Over the past 20 years, several studies have been conducted on the role of immune cells in hypertensive disorders of pregnancy. This study used bibliometric analysis to assess research hotspots and future trends in studies on immune cells in hypertensive disorders of pregnancy.MethodsWe extracted all relevant literature on immune cells and hypertensive disorders of pregnancy from the Web of Science core collection for the period of 2001 to 2021. We used VOS Viewer, CiteSpace, R-bibliometrix and Python for bibliometric analysis.ResultsWe identified 2,388 records published in 593 journals by 9,886 authors from 2,174 universities/institutions in 91 countries/regions. The number of publications tended to increase over time, with the highest number of publications in 2021, up to 205. The USA was the country with the most publications. UNIVERSITY OF MISSISSIPPI was the most influential institution. Lamarca B, Romero R, and Saito S were the most prolific authors. Finally, three research hotspot clusters were identified based on keywords, which reflected the role of immune cells in the development of hypertensive disorders of pregnancy, the current research status,and predicted hot spots for future research.ConclusionsOur study systematically analyzed the role of immune cells in the pathogenesis of hypertensive disorders of pregnancy in the last 20 years. Our results indicated that immune cells, such as T cells, natural killer (NK) cells,and macrophages, and the cytokines released such as TNF-α, IFN-γ in the maternal circulation and at the maternal-fetal interface would influence the development of hypertensive disorders of pregnancy and we need further investigate the role of individual immune cells and translational studies to provide new therapeutic perspectives to mitigate adverse perinatal outcomes due to hypertensive disorders of pregnancy. In conclusion, bibliometric studies provide a general overview of immune cells in the study of hypertensive disorders of pregnancy.

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“…Aunque se desconoce la etiología de la preeclampsia, se considera que la alteración de la placentación y de la tolerancia inmune, además de la acentuada respuesta inflamatoria vascular materna, son responsables de su aparición (13) . El material fibrinoide y las células espumosas ubicadas alrededor de las arterias espirales causan disminución del flujo sanguíneo, lo cual conduce a hipoxia (14) . Se ha descrito aumento de la estimulación de la producción de eritropoyetina secundaria a la hipoxia placentaria subyacente las preeclámpticas (3) .…”

Section: Discussionunclassified

Amplitud de la distribución eritrocitaria en el segundo trimestre del embarazo como predictor de preeclampsia

Torres-Cepeda¹,

Mejia-Montilla

Reyna-Villasmil

et al. 2022

Rev peru ginecol obstet.

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Objetivo. Establecer la utilidad de la amplitud de distribución eritrocitaria en el segundo trimestre del embarazo como predictor del desarrollo de preeclampsia. Diseño. Estudio de casos-controles. Institución. Hospital Central “Dr. Urquinaona”, Maracaibo, Venezuela. Participantes. Embarazadas entre 17 y 20 semanas que acudieron a la consulta prenatal y fueron seguidas hasta el término del embarazo. Métodos. Se tomaron muestras de sangre y fueron seguidas hasta el parto para establecer si desarrollaban preeclampsia. Principales medidas de resultado. Características generales, valores de la amplitud de la distribución eritrocitaria y eficacia pronóstica. Resultados. Los casos fueron 41 embarazadas que desarrollaron preeclampsia (grupo A) y 463 embarazadas fueron consideradas como controles (grupo B). No se encontraron diferencias estadísticamente significativas en la edad materna, edad gestacional y presión arterial sistólica y diastólica al momento de la realización de la ecografía (p = ns). La edad gestacional al momento del diagnóstico de preeclampsia en el grupo A fue de 35,0 +/- 3,2 semanas. Se encontraron diferencias significativas en los valores de amplitud de la distribución eritrocitaria entre las pacientes del grupo A (14,5 +/- 2,3%) y las pacientes del grupo B (13,8 +/- 1,8%; p = 0,039). Un valor de corte de 14% presentó un valor por debajo de la curva de 0,576 con sensibilidad del 63,4%, especificidad del 49,7%, valor predictivo positivo del 10,0% y valor predictivo negativo del 93,9%. Conclusión. Los valores de valores de la amplitud de la distribución eritrocitaria en el segundo trimestre no son útiles en la predicción de preeclampsia.

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Changes in Maternal Platelet Physiology during Gestation and Their Interaction with Trophoblasts

Cited by 18 publications

References 124 publications

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

Global trends in research of immune cells associated with hypertensive disorders of pregnancy: A 20-year bibliometric analyses (from 2001 to 2021)

Amplitud de la distribución eritrocitaria en el segundo trimestre del embarazo como predictor de preeclampsia

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