Changes in malondialdehyde levels in bronchoalveolar fluid and serum by the treatment of asthma with inhaled steroid and beta<sub>2</sub>‐agonist

Özaras, Reşat; Tahan, Veysel; Türkmen, Serdar; Talay, Fahrettin; Beşirli, Kazım; Aydın, Seval; Uzun, Hafize; Çetinkaya, Ali

doi:10.1046/j.1440-1843.2000.00260.x

Cited by 52 publications

(41 citation statements)

References 20 publications

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“…Elevated levels of oxidative stress markers such as H 2 O 2 , 8-isoprostane, nitric oxide, and carbon monoxide were reported in exhaled air of asthmatic patients [204]. Increased MDA levels, and Protein carbonyls; decreased protein sulfhydryl and antioxidant activity were observed in plasma, bronchoalveolar lavage (BAL) fluid and exhaled air of asthamatic patients [207][208][209].…”

Section: Asthmamentioning

confidence: 99%

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

2014

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Free radicals and other oxidants have gained importance in the field of biology due to their central role in various physiological conditions as well as their implication in a diverse range of diseases. The free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), are derived from both endogenous sources (mitochondria, peroxisomes, endoplasmic reticulum, phagocytic cells etc.) and exogenous sources (pollution, alcohol, tobacco smoke, heavy metals, transition metals,

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Section: Asthmamentioning

confidence: 99%

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

2014

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“…MDA was derived from TBARS to form the MDA-TBARS product, which was measured spectrophotometrically. 22 Statistical analysis Data were analyzed using SPSS for Windows Statistical Package (SPSS Inc., Chicago, IL, USA). Summary statistics of data were expressed as mean±s.d., median and range.…”

Section: Determination Of Npbi and Iron Indicesmentioning

confidence: 99%

Iron metabolism and lipid peroxidation products in infants with hypoxic ischemic encephalopathy

2008

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Background: Iron delocalization or misregulation of iron metabolism may play a critical role in the pathology of hypoxic ischemic encephalopathy (HIE).Objective: To study iron metabolism and lipid peroxidation in newborn infants and to correlate non-protein-bound iron (NPBI) concentration with the severity of the post-asphyxial injury and subsequent short-term outcomes.Study Design: Concentrations of NPBI and malondialdehyde (MDA) in the serum and in the cerebrospinal fluid (CSF) were measured in eight healthy newborn infants and nine newborn infants suffering from moderately severe HIE. Short-term outcomes (death, survival with or without neurological abnormality) were noted at hospital discharge.Result: Serum and CSF concentrations of both NPBI and MDA were significantly increased in HIE infants when compared to controls. Serum iron was significantly increased and total iron binding capacity was significantly decreased in HIE infants compared to controls. Out of the nine HIE infants, four infants died and two infants survived with abnormal neurological findings at hospital discharge. These six infants with clinical sequels had significantly increased concentrations of NPBI in the serum and in the CSF; and increased concentrations of MDA in the CSF when compared to the other three who survived without short-term abnormalities. Conclusion:We conclude that hypoxia ischemia alters iron metabolism and lipid peroxidation in newborn infants; and that NPBI and MDA in the CSF are increased in infants with HIE. This study supports a role for iron in oxidative injury to the central nervous system after hypoxic ischemic insults.

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“…Thiobarbituric acid-reactive substances (TBARS) measure the concentration of malondialdehyde (MDA), an end product of the oxidation and decomposition of polyunsaturated fatty acids containing three or more double bonds. Elevated MDA levels have been observed in both plasma [34][35][36][37] and breath condensate in asthmatics [38]. Ethane is produced following lipid peroxidation of n-3 fatty acids and elevated ethane levels have been reported in breath condensate of asthmatics [39].…”

Section: Evidence Relating Lipid Peroxidation and Asthmamentioning

confidence: 99%

Biomarkers of lipid peroxidation, airway inflammation and asthma

Wood¹,

Gibson²,

Garg³

2003

Eur Respir J

269

206

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Oxidative stress, specifically lipid peroxidation, is believed to contribute to the pathophysiology of asthma. This review highlights the pathways through which reactive oxygen species (ROS) may lead to lipid peroxidation. The potential of both the innate and acquired immune systems to activate inflammatory cells and release ROS that may overwhelm the host antioxidant defences and cause lipid peroxidation, accompanied by detrimental pathophysiological effects, are discussed.Despite the evidence demonstrating the importance of lipid peroxidation, systematic characterisation of oxidative stress and antioxidant defences has not been undertaken, largely due to the lack of appropriate biomarkers. This review discusses the emergence of isoprostanes (specifically 8-iso-prostaglandin F 2a ) as reliable, in vivo markers of lipid peroxidation, which provides an appropriate tool for studying oxidative stress. Furthermore, the development of techniques to study induced sputum and breath condensate, derived directly from the airway surface, enables the site of oxidative damage to be closely assessed.Evidence suggests that dietary changes that have occurred over recent years have increased susceptibility to lipid peroxidation, due to reduced antioxidant defences. To date, the limited number of long-term (w1 week) supplementation trials have been promising. However, the development of techniques to study isoprostanes in airwaylining fluid pave the way for further studies investigating the potential for antioxidant supplements to be used as routine therapy in asthma.

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Changes in malondialdehyde levels in bronchoalveolar fluid and serum by the treatment of asthma with inhaled steroid and beta₂‐agonist

Cited by 52 publications

References 20 publications

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Iron metabolism and lipid peroxidation products in infants with hypoxic ischemic encephalopathy

Biomarkers of lipid peroxidation, airway inflammation and asthma

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Changes in malondialdehyde levels in bronchoalveolar fluid and serum by the treatment of asthma with inhaled steroid and beta2‐agonist

Cited by 52 publications

References 20 publications

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Iron metabolism and lipid peroxidation products in infants with hypoxic ischemic encephalopathy

Biomarkers of lipid peroxidation, airway inflammation and asthma

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Product

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Changes in malondialdehyde levels in bronchoalveolar fluid and serum by the treatment of asthma with inhaled steroid and beta₂‐agonist