Changes in macular layers in the early course of non-arteritic ischaemic optic neuropathy

Keller, Johannes; Oakley, Jonathan D.; Russakoff, Daniel B.; Andorrà, Magí; Villoslada, Pablo; Sánchez-Dalmau, Bernardo

doi:10.1007/s00417-015-3066-3

Cited by 20 publications

(19 citation statements)

References 20 publications

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“…Because previous studies have reported that thinning of the macula and ganglion cell layer occurs as early as one month following the onset of NAION [14, 15], this result was not expected. One possible reason for this result is due to the different composition of central and peripheral retina.…”

Section: Discussionmentioning

confidence: 88%

Retinal Vessel Density in Optical Coherence Tomography Angiography in Optic Atrophy after Nonarteritic Anterior Ischemic Optic Neuropathy

Liu

Kao

Sun

et al. 2017

Journal of Ophthalmology

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Aims. To compare optical coherence tomography angiography (OCT-A) retinal vasculature measurements between normal and optic atrophy after nonarteritic anterior ischemic optic neuropathy (NAION) subjects. Design. This prospective observational study was conducted between July 2015 and August 2016 at the ophthalmology outpatient department of a referral center in Taiwan. Peripapillary (4.5 × 4.5 mm) and parafoveal (6 × 6 mm) OCT-A scans were acquired. Measurements of the peripapillary region were obtained in two areas: (1) circumpapillary vessel density (cpVD) and (2) whole enface image vessel density (wiVD). Results. 13 participants with optic atrophy after NAION had lower peripapillary vessel density than the 18 age-matched participants in the healthy control (HC) group (p < 0.001 for both cpVD and wiVD). However, the parafoveal vessel density was not significantly different between the two groups (p = 0.49). The areas under the receiver operating characteristic curve for the HC and NAION eyes were 0.992 for cpVD and 0.970 for wiVD. cpVD and wiVD were significantly correlated with the average retinal nerve fiber layer thickness (p < 0.001 for both). Conclusion. Peripapillary retinal perfusion is significantly decreased in optic atrophy after NAION. OCT-A may aid in the understanding of structure-function-perfusion relationships in NAION.

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Section: Discussionmentioning

confidence: 88%

Retinal Vessel Density in Optical Coherence Tomography Angiography in Optic Atrophy after Nonarteritic Anterior Ischemic Optic Neuropathy

Liu

Kao

Sun

et al. 2017

Journal of Ophthalmology

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“…Furthermore, the results obtained from the custom built UHR-OCT may limit the generalization of our current findings. However, the Orion Software used in the present study has been adapted in commercial OCT devices such as Zeiss Cirrus HD-OCT (with special data exportation), 44,45 Topcon 3D-1000 (Topcon Medical Systems, Inc., Oakland, NJ, USA), 46 and Spectralis SD OCT (Heidelberg Engineering, Heidelberg, Germany). 47 Our study can be repeated using these commercial OCT devices and the Orion software.…”

Section: Discussionmentioning

confidence: 99%

Focal Thickness Reduction of the Ganglion Cell-Inner Plexiform Layer Best Discriminates Prior Optic Neuritis in Patients With Multiple Sclerosis

Jiang

Gameiro

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…Yet, these commercially available OCT devices generate automated thickness maps for only limited layers such as TRT and GCIPL thicknesses 21,31,32. The advances in automated and semiautomated segmentation have facilitated delineation of multiple intraretinal layers in three dimensions 27,29,30,33,34. However, with the exception of Orion, a software that automates the thickness mappings of six to eleven intraretinal layers is not commercially available.…”

Section: Discussionmentioning

confidence: 99%

“…However, with the exception of Orion, a software that automates the thickness mappings of six to eleven intraretinal layers is not commercially available. Orion has been previously applied in processing volumetric data obtained from a commercial device (Cirrus HD-OCT), segmenting in this case, the thickness maps of six retinal layers 29. The software was adapted to our custom OCT, prompting our need for testing the repeatability of the intraretinal thicknesses ahead of performing further clinical studies.…”

Section: Discussionmentioning

confidence: 99%

The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

Tan¹,

Ye²,

Jiang³

et al. 2016

OPTH

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PurposeTo determine the repeatability and profiles with different partition methods in intraretinal thickness layers in healthy human subjects, using optical coherence tomography (OCT).MethodsA custom-built ultrahigh-resolution OCT was used to acquire three-dimensional volume of the macula in 20 healthy subjects. The dataset was acquired twice using the macular cube 512×128 protocol in an area of 6×6 mm2 centered on the fovea. Commercially available segmentation software (Orion™) was used to segment the dataset into thickness maps of six intraretinal layers. The coefficient of repeatability and intraclass coefficient of correlation (ICC) were analyzed using hemispheric zoning and sectors defined by the Early Treatment Diabetic Retinopathy Study (ETDRS).ResultsAll datasets were successfully segmented to create six thickness maps of individual intraretinal layers. Coefficients of repeatabilities of these layers in hemispheric zones ranged from 0.9 to 6.6 µm, with an average of 3.6 µm (standard deviation [SD] 1.4), which was not significantly different compared to ETDRS sectors (P>0.05). ICCs of these layers in hemispheric zones ranged from 0.68 to 0.99, with an average of 0.91 (SD 0.07). There were no significant differences in ICCs between two zoning methods (P>0.05). Significant variations of tomographic intraretinal thicknesses were found between the inner and outer annuli and among the quadrantal sectors within the inner and outer annuli (P<0.05). Significant variations of the quadrantal sectors including both inner and outer annuli were evident in intraretinal layers (P<0.05) except for the outer plexiform layer.ConclusionThe measurement repeatabilities of tomographic thicknesses of intraretinal layers are comparable using both hemispheric and ETDRS partitions in volumetric data combined with the commercially available segmentation software. In keeping with known, normal anatomical variation, significant differences in tomographic thickness in various intraretinal layers were apparent in both hemispheric and ETDRS sectors.

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Changes in macular layers in the early course of non-arteritic ischaemic optic neuropathy

Cited by 20 publications

References 20 publications

Retinal Vessel Density in Optical Coherence Tomography Angiography in Optic Atrophy after Nonarteritic Anterior Ischemic Optic Neuropathy

Retinal Vessel Density in Optical Coherence Tomography Angiography in Optic Atrophy after Nonarteritic Anterior Ischemic Optic Neuropathy

Focal Thickness Reduction of the Ganglion Cell-Inner Plexiform Layer Best Discriminates Prior Optic Neuritis in Patients With Multiple Sclerosis

The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

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