2012
DOI: 10.1371/journal.pcbi.1002409
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Changes in Lysozyme Flexibility upon Mutation Are Frequent, Large and Long-Ranged

Abstract: We investigate changes in human c-type lysozyme flexibility upon mutation via a Distance Constraint Model, which gives a statistical mechanical treatment of network rigidity. Specifically, two dynamical metrics are tracked. Changes in flexibility index quantify differences within backbone flexibility, whereas changes in the cooperativity correlation quantify differences within pairwise mechanical couplings. Regardless of metric, the same general conclusions are drawn. That is, small structural perturbations in… Show more

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Cited by 43 publications
(68 citation statements)
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References 84 publications
(135 reference statements)
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“…In general, helices are mostly rigid, whereas spanning loop regions are mostly flexible. [6466]. Based on that here, both mutant structures (R326H and R356Q) showed more helical content which leads to more rigidity in the conformation.…”
Section: Resultssupporting
confidence: 52%
“…In general, helices are mostly rigid, whereas spanning loop regions are mostly flexible. [6466]. Based on that here, both mutant structures (R326H and R356Q) showed more helical content which leads to more rigidity in the conformation.…”
Section: Resultssupporting
confidence: 52%
“…The observed status of beta fragments remains in good correspondence with the empirically determined role of each fragment of the human lysozyme [25].…”
Section: Discordant Core Structure With Some Sections Defined By Ss Bsupporting
confidence: 67%
“…Using the minimal Distance Constraint Model (mDCM), which we have used to characterize dynamic properties across several different groups of related proteins [37][42], we also characterize the extent of dynamical changes in BL. This work is particularly important because only a small number of class-A BL proteins have been studied by NMR and molecular dynamics simulation.…”
Section: Resultsmentioning
confidence: 99%