Changes in Lung Volumes Across GOLD Stages of COPD: Implications for Mechanisms of Air Trapping

Zeng, Siyang; Zhang, A.; Vasudevan, Sreelakshmi; Nishihama, M.; Giang, Brian; Dunn, Michelle; Bhogale, M.; Arjomandi, Mehrdad

doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5780

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The expiratory movement during calm breathing is mainly produced by the relaxation of the diaphragm and external intercostal muscles and the elastic retraction of the lungs pulling the thoracic cage [ 8 ]. The increase of pulmonary volume in COPD patients is caused by the increase of expiratory resistance caused by airway lesions and an increase in residual air volume, while the decreased elastic retraction force of the lungs also has a very important role in the increase of pulmonary volume in patients with COPD [ 9 ]. The forced expiratory volume in 1 s percent predicted (FEV 1 %pre) and the carbon monoxide diffusing capacity percent predicted (DLCO%pre) are important indices of lung function, and the values of both FEV 1 %pre and DLCO%pre are decreased in patients with lung disease [ 10 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Expression of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, and Changes in Alveolar Septa in Patients with Chronic Obstructive Pulmonary Disease

Zhang

et al. 2020

Med Sci Monit

View full text Add to dashboard Cite

Background This study investigated the relationship between the pathological alteration of alveolar septa and (1) pulmonary function and (2) matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) expression in chronic obstructive pulmonary disease (COPD). Material/Methods Sixty patients with pulmonary disease were divided into control (n=20) and COPD (n=40) groups. Postoperative lung tissue specimens were examined. Hematoxylin and eosin and elastin van Gieson staining detected pathological alterations of pulmonary alveolar septa. Septa thickness was measured. MMP-2, MMP-9, and TIMP-1 expression levels were detected by immunohistochemical staining. Correlations were determined by Pearson analysis. Results Forced expiratory volume in 1 s (FEV 1 ), forced vital capacity, FEV 1 percent predicted (FEV 1 %pre), and diffusion capacity of carbon monoxide percent predicted (DLCO%pre) in COPD patients were significantly lower than in those of the control group ( P <0.05). MMP-2, MMP-9, and TIMP-1 expression levels were significantly higher in the COPD group than in control, especially the severe group ( P <0.05). Septa thickness was negatively correlated with FEV 1 %pre ( r =−0.335; P <0.05) and positively correlated with MMP-2 and TIMP-1 expression ( P <0.05). Proportion of collagenous fiber was negatively correlated with FEV 1 %pre and DLCO%pre ( P <0.01), and positively correlated with MMP-2, MMP-9, and TIMP-1 expression ( P <0.01). Proportion of elastic fibers was negatively correlated with collagenous fiber. Conclusions The pathological alteration of alveolar septa was correlated with pulmonary function and expression levels of MMP-2, MMP-9, and TIMP-1, which can play vital roles in COPD progression.

show abstract

Section: Introductionmentioning

confidence: 99%

Expression of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, and Changes in Alveolar Septa in Patients with Chronic Obstructive Pulmonary Disease

Zhang

et al. 2020

Med Sci Monit

View full text Add to dashboard Cite

show abstract

Changes in Lung Volumes Across GOLD Stages of COPD: Implications for Mechanisms of Air Trapping

Cited by 1 publication

References 0 publications

Expression of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, and Changes in Alveolar Septa in Patients with Chronic Obstructive Pulmonary Disease

Expression of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, and Changes in Alveolar Septa in Patients with Chronic Obstructive Pulmonary Disease

Contact Info

Product

Resources

About