Changes in lung volume parameters regarding the received dose in the lobes of the lungs after locoregional radiotherapy of breast cancer

Abdemanafi, Mahsa; Tavakoli, Mahdi; Akhavan, Ali; Abedi, Iraj

doi:10.1016/j.rpor.2019.09.005

Cited by 2 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Breast cancer is the most common malignancy in women. 1,2 Adjuvant treatments including radiotherapy (RT), chemotherapy (CT) and hormone therapy are frequently applied to the patients after surgery. Adjuvant RT is applied to all patients after breast-conserving surgery (BCS) and in patients with positive lymph node and T3-4 after modified radical mastectomy (MRM).…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that loco-regional recurrences decrease with postoperative breast irradiation, and overall survival improves in high-risk patients. 1,3,4 The lungs are one of the organs most sensitive to ionizing radiation and the major dose limiting organ in breast irradiation. 5,6 During RT, part of the lungs is typically located in the field of RT and related toxicity develops.…”

Section: Introductionmentioning

confidence: 99%

“…5,6 During RT, part of the lungs is typically located in the field of RT and related toxicity develops. 1 Lung toxicity can be divided into two groups: early (within 6 months) pneumonia and late (after 6 months) pulmonary fibrosis. 1 Radiation fibrosis starts within a few months after RT and progresses over years, usually seen at 6-24th months after RT.…”

Section: Introductionmentioning

confidence: 99%

“…1 Lung toxicity can be divided into two groups: early (within 6 months) pneumonia and late (after 6 months) pulmonary fibrosis. 1 Radiation fibrosis starts within a few months after RT and progresses over years, usually seen at 6-24th months after RT. Radiological findings may include changes in the RT area, retractions in the lung parenchyma, volume loss, and pleural thickening.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Influence of Hormone Therapy on the Development of Pulmonary Fibrosis after Radiotherapy in Patients with Breast Cancer

Yavuz¹

2022

UHOD

View full text Add to dashboard Cite

The aim of the present study is to investigate the effects of hormone therapy on pulmonary fibrosis in patients who received curative conformal radiotherapy for breast cancer. Data of 469 patients were evaluated. Computerized tomography images were evaluated by a radiologist as blindly. The influence of hormone therapy (tamoxifen and aromatase inhibitors), age, menopause, radiotherapy fields, ipsilateral lung volume receiving 5 Gy (V5), ipsilateral lung volume receiving 20 Gy (V20), ipsilateral mean lung dose (MLD) and the effects of taxane group of chemotherapy on pulmonary fibrosis were investigated. The mean age was 51 (range 27-83) years. As hormone therapy, 159 patients (33.9%) used tamoxifen and 253 patients (53.9%) used aromatase inhibitors. A significant relationship was found between both 6th month lung fibrosis and 2nd year lung fibrosis, and V5, V20, MLD, regional lymphatic irradiation and hormone therapy use. More grade 2 fibrosis was detected in the patients who received tamoxifen compared to the patients who received aromatase inhibitors and the control group (p< 0.001). No association was found between menopausal status, age, and taxane group chemotherapy and lung fibrosis development. In multivariate analysis, V5, MLD, and using hormone therapy were shown to be independent predictors of the risk of developing fibrosis at both 6 months and 2 years. Use of tamoxifen increases early and late lung fibrosis more than aromatase inhibitors in patients who receive radiotherapy for breast cancer. However, V5, V20, MLD and regional lymph node irradiation also contribute to the prevalence of fibrosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Influence of Hormone Therapy on the Development of Pulmonary Fibrosis after Radiotherapy in Patients with Breast Cancer

Yavuz¹

2022

UHOD

View full text Add to dashboard Cite

show abstract

CT findings of acute radiation-induced pneumonitis in breast cancer

Jung

Shim

Kim

2021

BJR

View full text Add to dashboard Cite

Objectives: To evaluate the computed tomography (CT) findings of acute radiation pneumonitis (RP) in breast cancer patients undergoing postoperative radiotherapy, and to analyze clinico-dosimetric factors associated with acute RP. Methods: Between 2015 and 2017, 61 patients with breast cancer who underwent follow-up chest CT at 3 months after radiotherapy were analyzed. The degree of acute RP on CT was evaluated by the change of extent and scoring system (grade 0, no RP; Grade 1, ground-glass opacities (GGOs); Grade 2, GGOs and/or consolidations; Grade 3, clear focal consolidation; Grade 4, dense consolidation). The dosimetric parameters were calculated from the dose-volume histogram of RT. Results: The acute RP on CT was scored as follows: grade 0, in 37.7%, Grade 1 in 13.1%, Grade 2 in 44.3%, and Grade 3 in 4.9%. The median extent of RP in patients with Grades 1 to 3 was 6.2 ml (range, 0.2–95.9). There were no clinico-dosimetric factors significantly associated with the presence of RP or its severity. One patient developed symptomatic RP. Conclusions: This study showed no correlation between acute RP and clinico-dosimetric factors, and acute RP based on CT findings were much more common than symptomatic RP. Advances in knowledge: CT findings of acute RP or extent of RP were not significantly related to clinico-dosimetric factors in breast cancer patients.

show abstract

Changes in lung volume parameters regarding the received dose in the lobes of the lungs after locoregional radiotherapy of breast cancer

Cited by 2 publications

References 28 publications

The Influence of Hormone Therapy on the Development of Pulmonary Fibrosis after Radiotherapy in Patients with Breast Cancer

The Influence of Hormone Therapy on the Development of Pulmonary Fibrosis after Radiotherapy in Patients with Breast Cancer

CT findings of acute radiation-induced pneumonitis in breast cancer

Contact Info

Product

Resources

About