1987
DOI: 10.1002/jbt.2570020204
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Changes in lung ATP concentration in the rat after low‐level phosgene exposure

Abstract: Inhibition of mitochondrial respiratory activity and decreased lung adenosine triphosphate (ATP) concentration occur following exposure to 240 ppm.min phosgene. To determine the relationship between energy stores and the onset of phosgene-induced pulmonary edema, we measured the ATP concentration in rapidly frozen rat lung tissue before and during pulmonary edema. Male Sprague-Dawley rats were exposed to phosgene for four hours at concentrations of 0.05 to 1.0 ppm (12, 30, 60, 120, and 240 ppm.min). Lung wet a… Show more

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Cited by 30 publications
(12 citation statements)
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“…-, Data from 10-min exposures were excluded in the concentration-time-response analysis used in the "toxic load model." synthesis of glutathione and redox regulation, arachidonic acid metabolism, the release of proinflammatory cytokines, and cytoskeletal effects (F-actin organization) Franch & Hatch, 1986;Currie et al, 1985Currie et al, , 1987aCurrie et al, , 1987bGhio et al, 2005;Sciuto et al, 2002;Sciuto et al, 2003aSciuto et al, , 2003bSciuto et al, , 2003cSciuto et al, 2005;Duniho et al, 2002;Deshpande et al, 1996;Madden et al, 1991;Werrlein et al, 1994). Phosgeneinduced apoptotic changes in pneumocytes and inflammatory cells were described (Li et al, 2006).…”
Section: Inhalation Toxicity Of Phosgene In Experimental Modelsmentioning
confidence: 95%
“…-, Data from 10-min exposures were excluded in the concentration-time-response analysis used in the "toxic load model." synthesis of glutathione and redox regulation, arachidonic acid metabolism, the release of proinflammatory cytokines, and cytoskeletal effects (F-actin organization) Franch & Hatch, 1986;Currie et al, 1985Currie et al, , 1987aCurrie et al, , 1987bGhio et al, 2005;Sciuto et al, 2002;Sciuto et al, 2003aSciuto et al, , 2003bSciuto et al, , 2003cSciuto et al, 2005;Duniho et al, 2002;Deshpande et al, 1996;Madden et al, 1991;Werrlein et al, 1994). Phosgeneinduced apoptotic changes in pneumocytes and inflammatory cells were described (Li et al, 2006).…”
Section: Inhalation Toxicity Of Phosgene In Experimental Modelsmentioning
confidence: 95%
“…In laboratory animals, exposure to phosgene throughout a range of concentrations causes severe pathophysiologica l changes speci cally in the bronchoalveolar region (19,23). Exposure also produces changes in energy metabolism (3), disruption of the GSH redox cycle (22), and release of reactive arachidonic acid metabolites (9,12,21). Phosgene poisoning in man is associated with the development of latent noncardiogenic pulmonary edema, which can occur within 24 hours after exposure (5,24).…”
Section: Introductionmentioning
confidence: 99%
“…Because of its insoluble nature, phosgene causes these effects in the deeper regions of the lung where it can deplete ATP, important metabolic and antioxidant enzymes, and glutathione (Currie et al, 1987;Jaskot et al, 1991;Sciuto et al, 1995). Furthermore, phosgene has been show n to increase lipid peroxidation, cause the release of sulfidopeptide leukotrienes, alter important cell ultrastructures, and react directly with lung surfactant (Kennedy et al, 1989;Sciuto et al, 1996 a;Werrlein et al, 1994;Pawlow ski & Frosolono, 1977;Frosolono & Currie, 1985).…”
Section: Discussionmentioning
confidence: 93%