Changes in Local Bone Density in Early Thumb Carpometacarpal Joint Osteoarthritis

Schreiber, Joseph J.; McQuillan, Thomas; Halilaj, Eni; Crisco, Joseph J.; Weiss, Arnold‐Peter C.; Patel, Tirth K.; Kenney, Deborah; Ladd, Amy L.

doi:10.1016/j.jhsa.2017.09.004

Cited by 15 publications

(9 citation statements)

References 21 publications

(47 reference statements)

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“…We found 22% lower HU in the trapezium in high grade osteoarthritis patients (HU mean 288) compared with low grade osteoarthritis (HU mean 369) in Schreiber et al [ 19 ]. The low grade osteoarthritis patients from Schreiber et al had 12% lower HU than control subjects, and our high grade osteoarthritis patients had 31% lower HU then control subjects from Schreiber et al [ 19 ]. However, a limitation may be that OA grading has low intra-rater and inter-rater reliability [ 20 ].…”

Section: Discussionmentioning

confidence: 46%

“…Where CT is already used as a pre-operative examination when treating comminuted distal radius fractures, HU may give an indication of the bone quality of the radius and be of value when deciding on the specific fracture treatment e.g., augmentation by external fixation. In a recent study, HU was used to examine bone quality in the trapezium and revealed that bone density of the proximal metacarpal bone and the trapezium was lower in patients with first grade osteoarthritis in the trapeziometacarpal joint as compared to patients with no osteoarthritis [ 19 ]. We found 22% lower HU in the trapezium in high grade osteoarthritis patients (HU mean 288) compared with low grade osteoarthritis (HU mean 369) in Schreiber et al [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study, HU was used to examine bone quality in the trapezium and revealed that bone density of the proximal metacarpal bone and the trapezium was lower in patients with first grade osteoarthritis in the trapeziometacarpal joint as compared to patients with no osteoarthritis [ 19 ]. We found 22% lower HU in the trapezium in high grade osteoarthritis patients (HU mean 288) compared with low grade osteoarthritis (HU mean 369) in Schreiber et al [ 19 ]. The low grade osteoarthritis patients from Schreiber et al had 12% lower HU than control subjects, and our high grade osteoarthritis patients had 31% lower HU then control subjects from Schreiber et al [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Trapezium Bone Density—A Comparison of Measurements by DXA and CT

Mosegaard

Bouteldja

et al. 2018

JFB

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Bone density may influence the primary fixation of cementless implants, and poor bone density may increase the risk of implant failure. Before deciding on using total joint replacement as treatment in osteoarthritis of the trapeziometacarpal joint, it is valuable to determine the trapezium bone density. The aim of this study was to: (1) determine the correlation between measurements of bone mineral density of the trapezium obtained by dual-energy X-ray absorptiometry (DXA) scans by a circumference method and a new inner-ellipse method; and (2) to compare those to measurements of bone density obtained by computerized tomography (CT)-scans in Hounsfield units (HU). We included 71 hands from 59 patients with a mean age of 59 years (43–77). All patients had Eaton–Glickel stage II–IV trapeziometacarpal (TM) joint osteoarthritis, were under evaluation for trapeziometacarpal total joint replacement, and underwent DXA and CT wrist scans. There was an excellent correlation (r = 0.94) between DXA bone mineral density measures using the circumference and the inner-ellipse method. There was a moderate correlation between bone density measures obtained by DXA- and CT-scans with (r = 0.49) for the circumference method, and (r = 0.55) for the inner-ellipse method. DXA may be used in pre-operative evaluation of the trapezium bone quality, and the simpler DXA inner-ellipse measurement method can replace the DXA circumference method in estimation of bone density of the trapezium.

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Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Trapezium Bone Density—A Comparison of Measurements by DXA and CT

Mosegaard

Bouteldja

et al. 2018

JFB

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“…It was observed that the formation of bone redundancy was accompanied by a substantial bone loss in subchondral bone, with loss of normal bone structure in a rat OA model. Other partial findings also support the reduction of bone density in osteoarthritis (Schreiber et al, 2018;Muhlenfeld et al, 2021;Zhu Z. et al, 2021). A review in regard to the relationship between BMD and osteoarthritis of the knee by Choi et al (2021) showed that patients with moderate and severe OA had significantly lower BMD than the normal ones.…”

Section: The E Ects Of Irisin On Osteoarthritis Irisin and Bone Miner...mentioning

confidence: 76%

Exercise-induced modulation of myokine irisin in bone and cartilage tissue—Positive effects on osteoarthritis: A narrative review

Ning

Wang

Zhang

2022

Front. Aging Neurosci.

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Osteoarthritis is a chronic degenerative musculoskeletal disease characterized by pathological changes in joint structures along with the incidence of which increases with age. Exercise is recommended for all clinical treatment guidelines of osteoarthritis, but the exact molecular mechanisms are still unknown. Irisin is a newly discovered myokine released mainly by skeletal muscle in recent years—a biologically active protein capable of being released into the bloodstream as an endocrine factor, the synthesis and secretion of which is specifically induced by exercise-induced muscle contraction. Although the discovery of irisin is relatively recent, its role in affecting bone density and cartilage homeostasis has been reported. Here, we review the production and structural characteristics of irisin and discuss the effects of the different types of exercise involved in the current study on irisin and the role of irisin in anti-aging. In addition, the role of irisin in the regulation of bone mineral density, bone metabolism, and its role in chondrocyte homeostasis and metabolism is reviewed. A series of studies on irisin have provided new insights into the mechanisms of exercise training in improving bone density, resisting cartilage degeneration, and maintaining the overall environmental homeostasis of the joint. These studies further contribute to the understanding of the role of exercise in the fight against osteoarthritis and will provide an important reference and aid in the development of the field of osteoarthritis prevention and treatment.

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“…For both measurements, the points were first marked on the "PA" 3D view but subsequently adjusted while checking all around the 3D reconstruction image ensuring most accurate placement (►Figs. [1][2][3][4][5]. The same process was strictly followed for each specimen and performed by the first author.…”

Section: Methodsmentioning

confidence: 99%

Thumb Carpometacarpal Joint Pathoanatomy—A Computed Tomography-Based Study

et al. 2021

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Background Thumb carpometacarpal joint (CMCJ) osteoarthritis is common and can lead to significant morbidity making it a condition frequently treated by hand surgeons when initial conservative measures fail. The surrounding ligamentous structures are complex and important to maintain thumb CMCJ stability. Objectives The aim of this study was to review the normal and arthritic anatomy of the thumb CMCJ, focusing on morphology and position of osteophytes and the gap between metacarpal bases, and the effect of these on intermetacarpal ligament integrity. This may be the sole ligament suspending the first metacarpal following trapeziectomy and could determine the need for further stabilization during surgery, avoiding potential future failures. Methods Computed tomography (CT) scans of a normal cohort and those with arthritic changes who had undergone trapeziectomy following the scan were identified. The three-dimensional reconstructions were examined for osteophyte position on the saddle and the intermetacarpal distance. Results A total of 55 patients, 30 normal and 25 arthritic, were identified and studied. The most common anatomic position for osteophytes was the intermetacarpal ulnar aspect of the trapezium. The intermetacarpal distance increased by an average of 2.1 mm in the presence of the arthritic process. Conclusions The findings point to an increase in the intermetacarpal distance, and hence lengthening of the ligament with potential damage, possibly secondary to osteophyte formation and wear. Further prospective research is required to determine whether using preoperative CT scanning to define osteophyte position and measure the intermetacarpal distance would predict probable damage to the ligament, hence providing an indication for stabilization and reconstruction in trapeziectomy surgery. Level of Evidence This is a Level III, retrospective cohort study.

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Changes in Local Bone Density in Early Thumb Carpometacarpal Joint Osteoarthritis

Abstract: Diagnostic II.

Cited by 15 publications

References 21 publications

Trapezium Bone Density—A Comparison of Measurements by DXA and CT

Trapezium Bone Density—A Comparison of Measurements by DXA and CT

Exercise-induced modulation of myokine irisin in bone and cartilage tissue—Positive effects on osteoarthritis: A narrative review

Thumb Carpometacarpal Joint Pathoanatomy—A Computed Tomography-Based Study

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