Changes in liver function parameters after percutaneous radiofrequency ablation therapy in patients with hepatocellular carcinoma

Kuroda, Hidekatsu; Kasai, Kazuhiro; Kakisaka, Keisuke; Yasumi, Yuki; Kataoka, Koujiro; Ushio, Akira; Miyamoto, Yukio; Sawara, Kei; Oikawa, Kanta; Kondo, Koryo; Miura, Yoshiaki; Endo, Ryujin; Takikawa, Yasuhiro; Suzuki, Kazuyuki

doi:10.1111/j.1872-034x.2009.00613.x

Cited by 17 publications

(27 citation statements)

References 18 publications

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“…For example, Koda et al [10] reported that liver function in patients with low pre-treatment CP scores transiently deteriorated within the first month of observation, while patients with high pre-treatment CP scores exhibited a greater extent of deterioration over a longer term of observation, approximately 6 mo. In a study by Kuroda et al [11] , changes in liver function were monitored one year after RFA, and it was observed that a CP score of 9 or higher represented a major risk factor for aggravation of liver function following RFA. Furthermore, in another report by Yokoyama et al [12] , the influence of RFA treatments on long-term liver function was investigated.…”

Section: Discussionmentioning

confidence: 99%

“…Radiofrequency ablation (RFA) is currently recognized as an effective local treatment for HCC [5,6] and has been shown to be a relatively low risk procedure [7][8][9] . However, deterioration of liver function has been observed during the long-term follow-up of these patients [10][11][12] . Therefore, the risk factors that contribute to deterioration of liver function need to be identified.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the risk factors that contribute to deterioration of liver function need to be identified. Although a few reports have investigated changes in long-term liver function following RFA [10][11][12] , long-term liver function in patients with viral hepatitis-related HCC is still uncertain. The goal of this study was to identify risk factors for liver function deterioration in patients with HCC and viral hepatitis.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy

Honda

Seike

Oribe

et al. 2016

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AIM:To identify factors that influence long-term liver function following radiofrequency ablation (RFA) in patients with viral hepatitis-related hepatocellular carcinoma. METHODS:A total of 123 patients with hepatitis B virus-or hepatitis C virus-related hepatocellular carcinoma (HCC) (n = 12 and n = 111, respectively) were enrolled. Cumulative rates of worsening Child-Pugh (CP) scores (defined as a 2-point increase) were examined. RESULTS:CP score worsening was confirmed in 22 patients over a mean follow-up period of 43.8 ± 26.3 mo. Multivariate analysis identified CP class, platelet count, and aspartate aminotransferase levels as significant predictors of a worsening CP score (P = 0.000, P = 0.011 and P = 0.024, respectively). In contrast, repeated RFA was not identified as a risk factor for liver function deterioration. CONCLUSION:Long-term liver function following RFA was dependent on liver functional reserve, the degree Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy Retrospective Cohort Study ORIGINAL ARTICLEof fibrosis present, and the activity of the hepatitis condition for this cohort. Therefore, in order to maintain liver function for an extended period following RFA, suppression of viral hepatitis activity is important even after the treatment of HCC. Core tip: This study was conducted to identify risk factors for liver function deterioration following radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC) and viral hepatitis. A total of 123 patients with hepatitis B virus-or hepatitis C virusrelated HCC were enrolled. Cumulative rates of worsening Child-Pugh (CP) scores (defined as a 2-point increase) following RFA were examined. CP class, platelet count, and aspartate aminotransferase levels were identified as significant predictors of a worsening CP score. Suppression of viral hepatitis activity with anti-viral therapy is important even after the treatment of HCC in order to maintain liver function following RFA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy

Honda

Seike

Oribe

et al. 2016

WJH

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“…However, in the majority of patients, HCC generally develops against a background of liver cirrhosis. RFA against HCC sometimes worsens the liver parenchymal function (6). Deterioration of the liver function after RFA is problematic because HCC patients experience a high incidence of recurrence due to the development of minor intrahepatic metastasis and multicentric carcinogenesis (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Branched-chain Amino Acid Granules Improve the Non-protein Respiratory Quotient after Radiofrequency Ablation

et al. 2014

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Objective The supplementation of oral branched-chain amino acid (BCAA) granules is known to improve energy metabolism in cirrhotic patients, but not those with hepatocellular carcinoma (HCC). We aimed to clarify whether BCAA granules improve energy metabolism in HCC patients after radiofrequency ablation (RFA). Methods We performed a prospective cohort study (UMIN000004624) involving 40 HCC patients who underwent RFA at Kobe University Hospital. Indirect calorimetry and urinary/blood biochemical examinations were performed before and seven days after RFA. Blood biochemical examinations were also conducted three months after RFA. The patients treated with and without BCAA supplementation were compared, and univariate factors were statistically examined. Results The non-protein respiratory quotient (npRQ) and albumin levels before RFA were significantly lower in the BCAA group than in the control group (p=0.024 and 0.005). The npRQ ratio (seven days after/ before RFA) was significantly higher in the BCAA group than in the control group (p=0.019). In addition, the albumin ratio (three months after/before RFA) was significantly higher in the BCAA group than in the control group (p=0.018). Conclusion Supplementation with BCAA granules improves energy metabolism in addition to the liver function after RFA. Improvements in the liver function may result in consistently adequate treatment for HCC recurrence after RFA.

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“…Few reports on the safety and effectiveness of RFA for patients with poor liver function exist; this leads to difficulty in taking treatment-related decisions [16]. Therefore, we analyzed the outcomes and changes in liver function after RFA was used to treat HCC patients with Child-Pugh B/C liver cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

Radiofrequency Ablation for the Treatment of Hepatocellular Carcinoma with Decompensated Cirrhosis

et al. 2011

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Background: Radiofrequency ablation (RFA) is used to treat early-stage hepatocellular carcinoma (HCC), but is sometimes avoided in patients with decompensated liver cirrhosis because of the possible side effect of deterioration of liver function. Aims: In this study, we report the safety and effects of RFA for treating HCC patients with Child-Pugh B/C liver cirrhosis. Methods: Sixty-six consecutive HCC patients with Child-Pugh B/C cirrhosis, who were treated by RFA, were enrolled in this study. We analyzed patient outcomes, the complications of RFA, and changes in liver function and tumor markers. Results: Fifty-six patients were classified as Child-Pugh class B, and 10 were classified as class C. The overall survival rates in patients with Child-Pugh B and C cirrhosis were 82 and 83% at 1 year and 47 and 31% at 3 years, respectively. Serum total bilirubin (T.Bil), albumin, prothrombin time, ascites, and encephalopathy were unchanged at 1, 3, and 6 months after RFA in patients with Child-Pugh B cirrhosis; however, serum T.Bil levels increased significantly at 6 months after RFA in 6/10 (60%) patients with Child-Pugh C cirrhosis. Hemothorax and rupture of esophageal varices were observed in 2 patients; however, there were no complications related to poor liver function. Conclusion: RFA is a useful modality for treating HCC in patients with poor liver function such as Child-Pugh B and C, but careful monitoring after RFA must be needed.

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Changes in liver function parameters after percutaneous radiofrequency ablation therapy in patients with hepatocellular carcinoma

Cited by 17 publications

References 18 publications

Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy

Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy

Branched-chain Amino Acid Granules Improve the Non-protein Respiratory Quotient after Radiofrequency Ablation

Radiofrequency Ablation for the Treatment of Hepatocellular Carcinoma with Decompensated Cirrhosis

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