Changes in lipid peroxidation during pregnancy and after delivery in rats: effect of pinealectomy

Sáinz, Rosa M.; Reíter, Russel J.; Mayo, Juan C.; Cabrera, Javier; Tan, Dun Xian; Qi, Wenbo; García, Joaquín J.

doi:10.1530/jrf.0.1190143

Cited by 19 publications

(12 citation statements)

References 22 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Table 3 also supports the idea that reproduction can incur oxidative costs and that costs are likely to increase with reproductive effort, indicating that sampling animals during reproduction (i.e. at the peak of metabolic demands, [26-28]) provides more proof of the effects of reproduction on the oxidative balance (10 of 14 studies, Table 3) than through sampling at the end or after reproduction (0 of 2 studies, Table 3). It suggests that the oxidative imbalance induced by reproduction may be transient [29] and could easily be missed if the sampling is wrongly timed.…”

Section: Discussionmentioning

confidence: 56%

Constraint and cost of oxidative stress on reproduction: correlative evidence in laboratory mice and review of the literature

et al. 2012

View full text Add to dashboard Cite

BackgroundOne central concept in evolutionary ecology is that current and residual reproductive values are negatively linked by the so-called cost of reproduction. Previous studies examining the nature of this cost suggested a possible involvement of oxidative stress resulting from the imbalance between pro- and anti-oxidant processes. Still, data remain conflictory probably because, although oxidative damage increases during reproduction, high systemic levels of oxidative stress might also constrain parental investment in reproduction. Here, we investigated variation in oxidative balance (i.e. oxidative damage and antioxidant defences) over the course of reproduction by comparing female laboratory mice rearing or not pups.ResultsA significant increase in oxidative damage over time was only observed in females caring for offspring, whereas antioxidant defences increased over time regardless of reproductive status. Interestingly, oxidative damage measured prior to reproduction was negatively associated with litter size at birth (constraint), whereas damage measured after reproduction was positively related to litter size at weaning (cost).ConclusionsGlobally, our correlative results and the review of literature describing the links between reproduction and oxidative stress underline the importance of timing/dynamics when studying and interpreting oxidative balance in relation to reproduction. Our study highlights the duality (constraint and cost) of oxidative stress in life-history trade-offs, thus supporting the theory that oxidative stress plays a key role in life-history evolution.

show abstract

Section: Discussionmentioning

confidence: 56%

Constraint and cost of oxidative stress on reproduction: correlative evidence in laboratory mice and review of the literature

et al. 2012

View full text Add to dashboard Cite

show abstract

“…While this type of sampling is more practical for field and longitudinal studies, individual tissue types may vary in the level of oxidative damage exhibited at a given time within an animal (see [35]). Reproductive female Sprague-Dawley rats have higher levels of lipid oxidation in lung, uterus, brain, kidney and thymus, but not in the liver or spleen, relative to non-reproductive females [36] and reproductive female mice have less protein and lipid oxidation, higher concentration of antioxidants in the liver, and less lipid oxidation in skeletal muscle than do non-reproductive females (this difference was not detected in the serum; [26]). In bank voles ( Myodes gareolus ) lipid oxidation was lower in skeletal muscle and kidney and protein oxidation tended to be lower in the heart of reproductive females relative to non-reproductive females, whereas there was no difference in levels of oxidative damage in the liver between reproductive and non-reproductive females [37].…”

Section: Introductionmentioning

confidence: 95%

Reproduction Is Associated with a Tissue-Dependent Reduction of Oxidative Stress in Eusocial Female Damaraland Mole-Rats (Fukomys damarensis)

2014

View full text Add to dashboard Cite

Oxidative stress has been implicated as both a physiological cost of reproduction and a driving force on an animal's lifespan. Since increased reproductive effort is generally linked with a reduction in survival, it has been proposed that oxidative stress may influence this relationship. Support for this hypothesis is inconsistent, but this may, in part, be due to the type of tissues that have been analyzed. In Damaraland mole-rats the sole reproducing female in the colony is also the longest lived. Therefore, if oxidative stress does impact the trade-off between reproduction and survival in general, this species may possess some form of enhanced defense. We assessed this relationship by comparing markers of oxidative damage (malondialdehyde, MDA; protein carbonyls, PC) and antioxidants (total antioxidant capacity, TAC; superoxide dismutase, SOD) in various tissues including plasma, erythrocytes, heart, liver, kidney and skeletal muscle between wild-caught reproductive and non-reproductive female Damaraland mole-rats. Reproductive females exhibited significantly lower levels of PC across all tissues, and lower levels of MDA in heart, kidney and liver relative to non-reproductive females. Levels of TAC and SOD did not differ significantly according to reproductive state. The reduction in oxidative damage in breeding females may be attributable to the unusual social structure of this species, as similar relationships have been observed between reproductive and non-reproductive eusocial insects.

show abstract

“…Much of this research has focussed on mammals, mostly rodents, and almost exclusively on females. While some mammalian studies have supported the idea that investment in offspring production (during pregnancy and lactation) causes oxidative damage (Sainz et al 2000;Bergeron et al 2011;Stier et al 2012;Fletcher et al 2013), others have found no effect or that oxidative damage is actually reduced in lactating compared to nonreproducing females (Garratt et al 2011(Garratt et al , 2013Oldakowski et al 2012;Schmidt et al 2014). The biological relevance of this diversity in response is unclear and has often been explained by individual, species, tissue or assay differences, and the difference between studies in the laboratory and field (see Themes 2 and 3 below).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and life histories: unresolved issues and current needs

Speakman

Blount

Bronikowski

et al. 2015

Ecology and Evolution

170

203

View full text Add to dashboard Cite

Life‐history theory concerns the trade‐offs that mold the patterns of investment by animals between reproduction, growth, and survival. It is widely recognized that physiology plays a role in the mediation of life‐history trade‐offs, but the details remain obscure. As life‐history theory concerns aspects of investment in the soma that influence survival, understanding the physiological basis of life histories is related, but not identical, to understanding the process of aging. One idea from the field of aging that has gained considerable traction in the area of life histories is that life‐history trade‐offs may be mediated by free radical production and oxidative stress. We outline here developments in this field and summarize a number of important unresolved issues that may guide future research efforts. The issues are as follows. First, different tissues and macromolecular targets of oxidative stress respond differently during reproduction. The functional significance of these changes, however, remains uncertain. Consequently there is a need for studies that link oxidative stress measurements to functional outcomes, such as survival. Second, measurements of oxidative stress are often highly invasive or terminal. Terminal studies of oxidative stress in wild animals, where detailed life‐history information is available, cannot generally be performed without compromising the aims of the studies that generated the life‐history data. There is a need therefore for novel non‐invasive measurements of multi‐tissue oxidative stress. Third, laboratory studies provide unrivaled opportunities for experimental manipulation but may fail to expose the physiology underpinning life‐history effects, because of the benign laboratory environment. Fourth, the idea that oxidative stress might underlie life‐history trade‐offs does not make specific enough predictions that are amenable to testing. Moreover, there is a paucity of good alternative theoretical models on which contrasting predictions might be based. Fifth, there is an enormous diversity of life‐history variation to test the idea that oxidative stress may be a key mediator. So far we have only scratched the surface. Broadening the scope may reveal new strategies linked to the processes of oxidative damage and repair. Finally, understanding the trade‐offs in life histories and understanding the process of aging are related but not identical questions. Scientists inhabiting these two spheres of activity seldom collide, yet they have much to learn from each other.

show abstract

Changes in lipid peroxidation during pregnancy and after delivery in rats: effect of pinealectomy

Cited by 19 publications

References 22 publications

Constraint and cost of oxidative stress on reproduction: correlative evidence in laboratory mice and review of the literature

Constraint and cost of oxidative stress on reproduction: correlative evidence in laboratory mice and review of the literature

Reproduction Is Associated with a Tissue-Dependent Reduction of Oxidative Stress in Eusocial Female Damaraland Mole-Rats (Fukomys damarensis)

Oxidative stress and life histories: unresolved issues and current needs

Contact Info

Product

Resources

About