Changes in lipid peroxidation and antioxidant enzyme activity of human red blood cells after myocardial infarction

László, A; Matkovics, B.; Varge, Sz.Ilona; Wittman, Tibor; Fazekas, Tamás

doi:10.1016/0009-8981(91)90319-8

Cited by 11 publications

(3 citation statements)

References 10 publications

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“…No previous prospective study has investigated the association between CAT and CHD. The null association between CAT and CHD in our study conflicts with the results of several case-control studies that found inverse associations between CAT and CHD (25,26,30). Similarly, the discrepancy may be due to different study designs (i.e., whether blood was collected before or after CHD diagnoses), as mentioned above.…”

Section: Discussioncontrasting

confidence: 99%

“…Many studies have investigated the associations of SOD, GPx, and CAT activities with CHD among individuals who already have CHD (22)(23)(24)(25)(26); however, few prospective studies have examined the associations of SOD, GPx, and CAT activities in erythrocytes with future CHD events within generally healthy, free-living populations. In this prospective study of women who were free of cardiovascular disease at the time of blood collection, SOD, GPx, and CAT activities were not associated with risk of CHD.…”

Section: Discussionmentioning

confidence: 99%

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Erythrocyte Superoxide Dismutase, Glutathione Peroxidase, and Catalase Activities and Risk of Coronary Heart Disease in Generally Healthy Women: A Prospective Study

Yang¹,

Jensen²,

Rimm³

et al. 2014

American Journal of Epidemiology

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Erythrocyte antioxidant enzymes are major circulating antioxidant enzymes in the oxidative stress defense system. Few prospective studies have assessed the association between these enzymes and the risk of coronary heart disease (CHD) in generally healthy adults. We conducted a prospective nested case-control study of CHD among 32,826 women at baseline with 15 years of follow-up from 1989 to 2004 in the Nurses' Health Study. We investigated the association of baseline erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities with the risk of CHD. A total of 365 cases and 728 controls were included in the analysis. Overall, the relative risks of CHD associated with 1-standard deviation higher SOD, GPx, and CAT activities were 1.07 (95% confidence interval (CI): 0.94, 1.22), 1.04 (95% CI: 0.91, 1.18), and 1.04 (95% CI: 0.92, 1.17), respectively. Multivariable adjustments did not change the associations appreciably. Fasting status did not modify the associations, with the exception that SOD activity was positively associated with the risk of CHD among participants who provided blood samples within 12 hours of fasting. Overall, activities of SOD, GPx, and CAT were not associated with CHD among women who were generally healthy at the time of blood collection.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Erythrocyte Superoxide Dismutase, Glutathione Peroxidase, and Catalase Activities and Risk of Coronary Heart Disease in Generally Healthy Women: A Prospective Study

Yang¹,

Jensen²,

Rimm³

et al. 2014

American Journal of Epidemiology

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“…28 CAT in turn converts the peroxide into molecular oxygen and water, thus nullifying the pro-oxidative effect of the free radicals. 29 However, the presence of superoxide radicals inhibits the activity of CAT. Singlet oxygen and peroxyl radicals also affect SOD and CAT activities.…”

Section: Discussionmentioning

confidence: 99%

Influence of flavonoid extracts from celery on oxidative stress induced by dichlorvos in rats

Cao

Zhang²,

Wang³

et al. 2011

Hum Exp Toxicol

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The present work was to investigate the effects of flavonoid extracts from celery on oxidative stress induced by dichlorvos (DIC) in male Wistar rats maintained on a normal diet. The rats were given DIC through intragastric administration by the dose of 7.2 mg/kg·body weight (bw)/day and additionally added 5% flavonoid extracts to the diet for 4 weeks continuously. The activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione-S-transferase (GST) and the content of malondialdehyde (MDA) in livers of rats were measured at the end of the experiment. Under the influence of DIC, there were significant decrease in the activities of SOD, CAT and GST and significant increase in GPx activity and MDA content. The results also showed that the activities of SOD, GST and CAT in the DIC-treated group declined significantly when compared with the flavonoid extracts group and the DIC + flavonoid extracts group, respectively. With regard to GPx activity and MDA content, significant increase were showed in the DIC-treated group in comparison to those in the flavonoid extracts group and the DIC + flavonoid extracts group, respectively. The observations presented lead us to conclude the harmful effects of DIC during the exposure and the protective role of flavonoids in minimizing these effects.

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Correlation of Clinical and Histopathological Grades in Oral Submucous Fibrosis Patients with Oxidative Stress Markers in Saliva

et al. 2017

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This study aimed to correlate the oxidative stress marker levels in saliva with the clinical stage based on mouth opening, fibrotic bands and histopathological grades of oral submucous fibrosis (OSF) patients. The study included patients clinically diagnosed with OSF (n = 63) and equal number of age and gender matched controls. Patients with OSF were defined by mouth opening stage, fibrotic bands and histopathological grades. Unstimulated saliva from both control and OSF patients were analysed for oxidative markers like lipid peroxides (LPO), non-enzymic antioxidants [reduced glutathione (GSH), vitamin A, vitamin E, vitamin C] and enzymatic antioxidants [glutathione peroxidase (GPx), superoxide dismutase (SOD)] and correlated with different stages and grades. Total salivary protein and LPO were significantly increased in OSF group with no significant change in the levels of GSH compared to controls. In OSF patients, a significant decrease in the levels of vitamins A, C and E was observed. The activities of salivary SOD and GPx were significantly decreased in OSF patients compared to controls. These changes significantly correlated with the increasing and differing grades of OSF that reflects increased oxidative stress with the progress of OSF.

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Changes in lipid peroxidation and antioxidant enzyme activity of human red blood cells after myocardial infarction

Cited by 11 publications

References 10 publications

Erythrocyte Superoxide Dismutase, Glutathione Peroxidase, and Catalase Activities and Risk of Coronary Heart Disease in Generally Healthy Women: A Prospective Study

Erythrocyte Superoxide Dismutase, Glutathione Peroxidase, and Catalase Activities and Risk of Coronary Heart Disease in Generally Healthy Women: A Prospective Study

Influence of flavonoid extracts from celery on oxidative stress induced by dichlorvos in rats

Correlation of Clinical and Histopathological Grades in Oral Submucous Fibrosis Patients with Oxidative Stress Markers in Saliva

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