Changes in levels of copper, iron, zinc, and selenium in patients at different stages of chronic kidney disease

Shih, Ching‐Tang; Shiu, Ying-Ling; Chen, Chiou-An; Lin, Hsin-Yu; Huang, Yeou‐Lih; Lin, Ching‐Chiang

doi:10.1016/j.gmbhs.2013.03.001

Cited by 23 publications

(15 citation statements)

References 9 publications

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“…The mean serum Zinc level for the case and control are 578.35 µg/L and 771.80 µg/L, respectively. The decrease in levels of zinc found in this investigation is also expected as per Shih et al [19]. The mean serum Copper and Zinc for cases were higher and lower, respectively than that of controls, which is in agreement with the literature.…”

Section: Discussionsupporting

confidence: 93%

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Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: an observational study

Choudhury

Zaman

Chowdhury

et al. 2021

Preprint

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The traditional causes of Chronic Kidney Damage (CKD) are Diabetes and Hypertension. However, recent studies reported the possible relations between metal exposure and CKD. This study aims to explore the status of metals in CKD patients compared to their healthy counterparts at Narayanganj, Bangladesh, through a cross-sectional study. In this study, 50 volunteers have involved; 30 CKD patients and 20 healthy controls. Five metals were measured from serum (Cu and Zn) and urine (Pb, Cd, and Cr) using Atomic Absorption Spectrophotometer (Varian AA240 FS). Compared to the controls and the CKD patients were exhibited a significantly higher level of Pb and Cr in their urine samples. As expected, it was observed that the cases had higher levels of Pb, Cd, and Cr in their urine. This signifies a potential association between heavy metal exposure and CKD. The serum levels of Cu were much higher than expected for CKD patients than controls, and the Zn values were in accordance with established literature. However, the level of Zn in blood was significantly lower in the CKD group compared to the control. This data suggests that the Cu imbalance in the serum of the CKD subjects might have been related to a myriad of reasons, one of which being exposed to large concentrations of the nephrotoxic metals such as Pb and Cr in this study. Large scale epidemiological study is warranted in Bangladesh to examine environmental health in relation to nephrology.

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Section: Discussionsupporting

confidence: 93%

“…The mean for serum Copper for case and control are 816.99 µg/L and 511.49 µg/L, respectively. The increase in the copper levels in CKD affected people are expected [19]. The mean serum Zinc level for the case and control are 578.35 µg/L and 771.80 µg/L, respectively.…”

Section: Discussionmentioning

confidence: 93%

Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: an observational study

Choudhury

Zaman

Chowdhury

et al. 2021

Preprint

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“…In this study, LA-ICP-MS proved to be suitable for this type of analyses. The order of measured elements concentrations in kidneys was as follows: Fe > Zn > Cu, which is in accordance with previous findings in human kidney [19]. Copper transporter Ctr1 is highly expressed in proximal and distal tubular cells in mouse kidneys [17] and has been also demonstrated to mediate the cellular uptake of cisplatin.…”

Section: Discussionsupporting

confidence: 91%

Determination of Renal Distribution of Zinc, Copper, Iron, and Platinum in Mouse Kidney Using LA-ICP-MS

Štěpka

Kratochvílová

Kuchynka

et al. 2021

BioMed Research International

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The main dose-limiting side effect of cisplatin is nephrotoxicity. The utilization of cisplatin is an issue of balancing tumour toxicity versus platinum-induced nephrotoxicity. In this study, we focused on intraorgan distribution of common essential trace elements zinc, copper, and iron in healthy mouse kidneys and distribution of platinum after cisplatin treatment. Renal distribution in 12 nontreated Nu-Nu mice (males) was assessed by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Furthermore, 9 Nu-Nu mice were treated with cisplatin. The order of elements concentration in kidneys was as follows: Fe > Zn > Cu. All three metals showed the higher concentrations at the cortex and medulla (28.60, 3.35, and 93.83 μg/g for Zn, Cu, and Fe, respectively) and lower concentration at the pelvis and the urinary tract (20.20, 1.93, and 62.48 μg/g for Zn, Cu, and Fe, respectively). No statistically significant difference between cortex and medulla was observed for these elements. After platinum treatment, the concentration of platinum in kidneys was enhanced more than 60-times, p < 0.001 . Platinum significantly showed the highest accumulation in cortex (2.11 μg/g) with a gradient distribution. Platinum was less accumulated in medulla and pelvis than in cortex, and the lowest accumulation occurred in the urinary tract (1.13 μg/g). Image processing has been successfully utilized to colocalize metal distribution using LA-ICP-MS and histological samples images.

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“…Another study showed that the percentage of circulating neutrophils, serum IL-2R and the antibody titer against the Beijing strain of influenza were significantly reduced in individuals with the higher copper intake (7.8 mg/day) [ 140 ]. Some researchers have shown that the status of copper is apparently not influenced by CKD and no significant differences in the copper levels have been observed between the four stages of CKD [ 141 , 142 ]. However, the increased level of copper in erythrocytes was correlated with increasing the severity of the renal failure.…”

Section: Nutrients and Bioactive Compoundsmentioning

confidence: 99%

Kidney diseases and COVID-19 infection: causes and effect, supportive therapeutics and nutritional perspectives

Askari

Sanadgol

Azarnezhad

et al. 2021

Heliyon

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Recently, the novel coronavirus disease 2019 , has attracted the attention of scientists where it has a high mortality rate among older adults and individuals suffering from chronic diseases, such as chronic kidney diseases (CKD). It is important to elucidate molecular mechanisms by which COVID-19 affects the kidneys and accordingly develop proper nutritional and pharmacological strategies. Although numerous studies have recently recommended several approaches for the management of COVID-19 in CKD, its impact on patients with renal diseases remains the biggest challenge worldwide. In this paper, we review the most recent evidence regarding causality, potential nutritional supplements, therapeutic options, and management of COVID-19 infection in vulnerable individuals and patients with CKD. To date, there is no effective treatment for COVID-19-induced kidney dysfunction, and current treatments are yet limited to anti-inflammatory (e.g. ibuprofen) and anti-viral medications (e.g. Remdesivir, and Chloroquine/Hydroxychloroquine) that may increase the chance of treatment. In conclusion, the knowledge about kidney damage in COVID-19 is very limited, and this review improves our ability to introduce novel approaches for future clinical trials for this contiguous disease.

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Changes in levels of copper, iron, zinc, and selenium in patients at different stages of chronic kidney disease

Cited by 23 publications

References 9 publications

Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: an observational study

Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: an observational study

Determination of Renal Distribution of Zinc, Copper, Iron, and Platinum in Mouse Kidney Using LA-ICP-MS

Kidney diseases and COVID-19 infection: causes and effect, supportive therapeutics and nutritional perspectives

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