Changes in left ventricular size, geometry, pump function and left heart pressures during healthy aging

Peverill, Roger E.

doi:10.31083/j.rcm2203079

Cited by 14 publications

(9 citation statements)

References 64 publications

(168 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LV dimensions including LVEDd and LVESd decreased significantly over time, denoting reduced LV size. This is consistent with published longitudinal studies demonstrating marked reduction in LVEDd with physiological ageing [ 26 ]. Increased LVPWd is consistent with a thicker LV wall, seen in physiological ageing [ 27 ].…”

Section: Discussionsupporting

confidence: 93%

Phenoage and longitudinal changes on transthoracic echocardiography in Alström syndrome: a disease of accelerated ageing?

Patel,

Roy,

Alvior

et al. 2023

GeroScience

View full text Add to dashboard Cite

Alström syndrome (AS) is an ultra-rare disorder characterised by early-onset multi-organ dysfunction, such as insulin resistance, obesity, dyslipidaemia, and renal and cardiovascular disease. The objective is to explore whether AS is a disease of accelerated ageing and whether changes over time on echocardiography could reflect accelerated cardiac ageing. Cross-sectional measurement of Phenoage and retrospective analysis of serial echocardiography were performed between March 2012 and November 2022. The setting is a single national tertiary service jointly run by health service and patient charity. Forty-five adult patients aged over 16 years were included, 64% were male and 67% of White ethnicity. The median Phenoage was 48 years (interquartile range [IQR]: 35–72) in the 34 patients for whom this was calculable, which was significantly higher than the median chronological age of 29 years (IQR: 22–39, p<0.001). Phenoage was higher than chronological age in 85% (N=29) of patients, with a median difference of +18 years (IQR: +4, +34). On echocardiography, significant decreases were observed over time in left ventricular (LV) size at end-diastole (average of 0.046 cm per year, p<0.001) and end-systole (1.1% per year, p=0.025), with significant increase in posterior wall thickness at end-diastole (0.009 cm per year, p=0.008). LV systolic function measured by global longitudinal strain reduced (0.34 percentage points per year, p=0.020) and E/e’lat increased (2.5% per year, p=0.019). Most AS patients display a higher Phenoage compared to chronological age. Cardiac changes in AS patients were also reflective of accelerated ageing, with a reduction in LV size and increased wall thickening. AS may be a paradigm disease for premature ageing.

show abstract

Section: Discussionsupporting

confidence: 93%

Phenoage and longitudinal changes on transthoracic echocardiography in Alström syndrome: a disease of accelerated ageing?

Patel,

Roy,

Alvior

et al. 2023

GeroScience

View full text Add to dashboard Cite

show abstract

“…6C) can be expected, similar to that of the hemipteran salivary pump. A supporting fact for this claim is that, although hearts shrink during ageing, this does not affect their performance, as investigated for the size of the left ventricle (Peverill 2021).…”

Section: Flat Optimum With a High Plateaumentioning

confidence: 78%

A technomorphic conceptualisation of biological ‘constructions’ and their evolution

Drack¹,

Betz²

2022

View full text Add to dashboard Cite

Here, we build on earlier work concerning notions of engineering design and investigate their conceptual connection to evolutionary biology. The basis for this work is an engineering design schema covering the central concepts of function, working principle and construction. Its relevance for evolutionary biology is explored by connecting these concepts to the so-called design space that is used in engineering optimisation. This tool makes it possible to distinguish various optima of performance and to visualise their robustness with respect to disturbances or changes in parameters. The robustness of morphological ‘constructions’ with regard to changes of shape is shown by means of examples from engineering and biology. The characteristics of various ‘landscapes’ in the design space is then related to the concept of evolvability, whereby we explore analogies between systems biology and morphology. A general property of phenotypes from the molecular to the organismal level seems to be that their ‘construction’ facilitates both their robustness and their exploration of the design space while maintaining the performance of the relevant functions at a high level.

show abstract

“… 29 , 30 The lower CI in older people correlates with the conclusions of previous imaging-based studies, yet this is the first demonstration of continuous changes in CI along the circadian cycle across different age groups. 31 …”

Section: Discussionmentioning

confidence: 99%

Diurnal cardio-respiratory changes in ambulatory individuals deciphered using a multi-parameter wearable device

Nachman,

Eisenkraft,

Kolben

et al. 2023

DIGITAL HEALTH

View full text Add to dashboard Cite

Background Recent technological developments enable big data-driven insights on diurnal changes. This study aimed to describe the trajectory of multiple and advanced parameters using a medical-grade wearable remote patient monitor. Methods Parameters were monitored for 24 h in 256 ambulatory participants who kept living their normal life. Parameters included heart rate, blood pressure, stroke volume, cardiac index, systemic vascular resistance, blood oxygen saturation, and respiratory rate. Diurnal variations were evaluated, and analyses were stratified based on sex, age, and body mass index. Results All parameters showed diurnal changes ( p < 0.001). Females demonstrated higher heart rate and cardiac index with lower systemic vascular resistance. Obese participants had a higher blood pressure, and lower stroke volume and cardiac index. Systemic vascular resistance was higher among the elderly. Diurnal changes corresponded with awake–sleep hours and differed between sex, age, and body mass index groups. Conclusion Wearable monitoring platforms could decipher hemodynamic changes in subgroups of individuals, and might help with efforts to provide personalized medicine, pre-symptomatic diagnosis and prevention, and drug development.

show abstract

Changes in left ventricular size, geometry, pump function and left heart pressures during healthy aging

Cited by 14 publications

References 64 publications

Phenoage and longitudinal changes on transthoracic echocardiography in Alström syndrome: a disease of accelerated ageing?

Phenoage and longitudinal changes on transthoracic echocardiography in Alström syndrome: a disease of accelerated ageing?

A technomorphic conceptualisation of biological ‘constructions’ and their evolution

Diurnal cardio-respiratory changes in ambulatory individuals deciphered using a multi-parameter wearable device

Contact Info

Product

Resources

About