Changes in left ventricular function produced by the injection of contrast media

Mullins, C. Buddie; Leshin, Stephen J.; Mierzwiak, Donald S.; Alsobrook, Harold D.; Mitchell, Jere H.

doi:10.1016/0002-8703(72)90439-5

Cited by 83 publications

(15 citation statements)

References 24 publications

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“…This is thought to be due to a higher rate of ejection as a result of the large bolus of contrast material injected into the left ventricular chamber. Thus, in animals with endocardial radiopaque markers for comparison, a 1-ml/kg injection of angiographic dye elicited a 12% ejection fraction increment between the second and fourth beat, as calculated from the endocardial markers, and persisted at a higher level for many beats (19). Left ventricular systolic and diastolic pressures and the first derivative of ventricular pressure were increased by 15,22, and 17%, respectively.…”

Section: Methodsmentioning

confidence: 87%

Evidence for Cardiomyopathy in Familial Diabetes Mellitus

Regan¹,

Lyons²,

Ahmed³

et al. 1977

J. Clin. Invest.

688

313

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Section: Methodsmentioning

confidence: 87%

Evidence for Cardiomyopathy in Familial Diabetes Mellitus

Regan¹,

Lyons²,

Ahmed³

et al. 1977

J. Clin. Invest.

688

313

View full text Add to dashboard Cite

“…LV ejection fraction by this technique has shown good reproducibility both in a hydraulic model under nearly ideal conditions of mixing and sampling (11) and in the intact dog (12,13). The higher values obtained from the angiographic methods at similar levels of heart rate and aortic pressure may be due to a high rate of ejection as a result of the large bolus of contrast material injected in the LV chamber (14). Despite a systematic differeince between the two techniques, there is a good correlation of' the ejection f'raction derived from the indicator dilution and angiographic techni(lues, with r = 0.824 (15).…”

Section: Methodsmentioning

confidence: 90%

Sustained effect of glucose-insulin-potassium on myocardial performance during regional ischemia. Role of free fatty acid and osmolality.

Ahmed¹,

Lee²,

Oldewurtel³

et al. 1978

J. Clin. Invest.

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A B S T R A C T To evaluate the influence of glucose infusate administered with insulin and potassium on left ventricular function during 4 h of ischemia, as well as mechanism of action, four groups of intact anesthetized dogs were studied. Acute crease of plasma FFA in contrast to controls which manifested a significant rise. To examine the postulate that the decrease in FFA was important to therapeutic action, a third group was infused wvith Intralipid (Cutter Laboratories, Inc., Berkeley, Calif.) and heparin, simultaneously with the glucose infusate, to effect an elevation of plasma FFA durinig ischenmia. Changes in myocardial function and electrolyte composition, as well as precordial electrocardiograimi mapping, were similar to that of animals receiving glucose alone. Because serum osmolalitv wvas increased approximately 40 mosmol during the glucose infusion, the potential role of' hyperosmolalitv was assessed by infusion of 20% mannitol during acute ischemia in a fourth group. After a transient small increase, there was a moderate decline in ftunction by 4 h, suggesting that the response to glucose is not dependent upon extracellular osmolality. Thus, it is concluded that dutring the initial hours after the onset of myocardial ischemia the gltucose infusate improves ventricular performance without evidence of arrhythmia induction or intensification of isclemiiic injury. Evoltution of irreversible necrosis appears to be delayed rather than prevented uinder the circumilstances of this study.

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“…The noninvasive method of multigated radionuclide angiography is probably the most accurate method of determining ventricular volumes, since calculations are made independent of geometric assumptions (20,26,27,29- 3 1). Also, the standard angiographic dyes have been determined to alter ventricular function as well as the status of the peripheral vascular system (32)(33)(34)(35). With radionuclide angiography, separation of left ventricular activity and potentially overlapping left atrial activity may be more difficult in the supine than in the upright state; however, on inspection, the overlap was mild in both positions, since none of the subjects had mitral regurgitation or atrial enlargement.…”

Section: Discussionmentioning

confidence: 99%

Position as a variable for cardiovascular responses during exercise

Cotsamire

Sullivan

Bashore

et al. 1987

Clinical Cardiology

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Summary: Twenty-one normal young male subjects underwent resting and exercise (bicycle) radionuclide angiography in the full supine and 70" upright tilt positions in order to examine the effects of position on left ventricular size and performance, hemodynamics, and exercise duration. All subjects also underwent full (90") upright bicycle ergometry with respiratory gas analysis to establish the level of maximal exercise capacity for each. Body position significantly (p < 0.05) affected resting and exercise cardiovascular parameters. End-diastolic and endsystolic left ventricular volumes and stroke volume were larger in the supine position, both at rest and during exercise. The cardiac output at rest and during exercise were comparable for the two positions; an increase in resting and exercise heart rate in the 70" tilt position compensated for the reduced stroke volume of this posture. At maximal exercise, the 70" upright position was associated with a greater response in left ventricular ejection fraction, otherwise this parameter was not position related. Exercise capacity, in terms of duration and workload, was significantly higher in the supine (1 870 +390 s) and full upright (1830+250 s) positions than in the 70" tilt position (173Ok260 s). Changes in body position significantly alter parameters of ventricular, cardiovascular, and exercise performance.

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Changes in left ventricular function produced by the injection of contrast media

Cited by 83 publications

References 24 publications

Evidence for Cardiomyopathy in Familial Diabetes Mellitus

Evidence for Cardiomyopathy in Familial Diabetes Mellitus

Sustained effect of glucose-insulin-potassium on myocardial performance during regional ischemia. Role of free fatty acid and osmolality.

Position as a variable for cardiovascular responses during exercise

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